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controlling osteoclastic bone resorption ( 32 ). RANK, RANKL and OPG are members of the TNF superfamily. Besides bone, RANK and RANKL are also expressed by various cells of the immune system, as RANKL is found on T and B cells and RANK on DCs, macrophages
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of autoimmune diseases by suppressing effector T cells and B cells ( 6 ). The immunosuppressive mechanisms employed by Tregs include the expression of cytotoxic T-lymphocyte antigen-4 (CTLA-4) to suppress costimulation, consumption of interleukin-2