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Keiko Ohkuwa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Mitsuji Nagahama Department of Surgery, Ito Hospital, Tokyo, Japan

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Wataru Kitagawa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kenichi Matsuzu Department of Surgery, Ito Hospital, Tokyo, Japan

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Akifumi Suzuki Department of Surgery, Ito Hospital, Tokyo, Japan

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Chisato Tomoda Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiyomi Hames Department of Surgery, Ito Hospital, Tokyo, Japan

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Junko Akaishi Department of Surgery, Ito Hospital, Tokyo, Japan

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Chie Masaki Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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Introduction The incidence of thyroid cancer has increased over the previous decade. The 5- and 10-year relative survival rates for patients with differentiated thyroid cancer (DTC) are 90–95% ( 1 , 2 ). Distant metastasis occurs in 5–20% of

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Jiaxin Luo Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Weili Yin Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Qiuxia Lin The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China

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Juqing Wu Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Pan Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yuanna Ling Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jing Wang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Zhen Li Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Liqin Pan Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yanying Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wei Ouyang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Huijuan Feng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Introduction Bone metastasis is the second most common type of distant metastasis in differentiated thyroid cancer (DTC) after lung metastasis, with an incidence of 2–13%, strongly suggesting a poor prognosis ( 1 , 2 , 3 , 4 , 5 , 6

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Natalie Su-Jing Yap Departments of Endocrinology, Radiology, Sydney Medical School, Royal North Shore Hospital, St Leonards, New South Wales, Australia

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Richard Maher Departments of Endocrinology, Radiology, Sydney Medical School, Royal North Shore Hospital, St Leonards, New South Wales, Australia

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Diana Louise Learoyd Departments of Endocrinology, Radiology, Sydney Medical School, Royal North Shore Hospital, St Leonards, New South Wales, Australia
Departments of Endocrinology, Radiology, Sydney Medical School, Royal North Shore Hospital, St Leonards, New South Wales, Australia

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available 1/24 1/26 FNA-Tg, thyroglobulin in needle washouts from fine-needle aspiration biopsy; DTC, differentiated thyroid carcinoma; AJCC/UICC TNM, American Joint Committee on Cancer/International Union against Cancer TNM Classification System for

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Mabel E Bohórquez Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia

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Ana P Estrada Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia

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Jacob Stultz Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Ruta Sahasrabudhe Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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John Williamson Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Paul Lott Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA

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Carlos S Duque Hospital Pablo Tobón Uribe, Medellín, Colombia

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Jorge Donado Hospital Pablo Tobón Uribe, Medellín, Colombia

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Gilbert Mateus Hospital Federico Lleras Acosta, Ibagué, Colombia

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Fernando Bolaños Hospital Hernando Moncaleano Perdomo, Neiva, Colombia

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Alejandro Vélez Hospital Pablo Tobón Uribe, Medellín, Colombia

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Magdalena Echeverry Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia

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Luis G Carvajal-Carmona Grupo de Citogenética, Filogenia y Evolución de Poblaciones, Facultad de Ciencias y Facultad de Ciencias de la Salud, Universidad del Tolima, Ibagué, Colombia
Genome Center and Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA
Fundación de Genética y Genómica, Medellín, Colombia

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Introduction Thyroid cancer (TC) is becoming epidemic, growing in incidence both nationally and internationally ( 1 ). Nonmedullary thyroid cancer (NMTC) makes up over 95% of all cases, making it the most common endocrine malignancy ( 2

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Agnieszka Adamska Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Paulina Tomczuk-Bobik Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Anna Beata Popławska-Kita Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland

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Angelika Buczyńska Clinical Research Centre, Medical University of Bialystok, Białystok, Poland

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Piotr Szumowski Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland

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Łukasz Żukowski Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland

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Janusz Myśliwiec Department of Nuclear Medicine, Medical University of Białystok, Białystok, Poland

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Monika Zbucka-Krętowska Department of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Bialystok, Białystok, Poland

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Marcin Adamski Faculty of Computer Science, Bialystok University of Technology, Białystok, Poland

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Adam Jacek Krętowski Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
Clinical Research Centre, Medical University of Bialystok, Białystok, Poland

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Introduction One of the most common types of endocrine cancer, especially in young women, is thyroid cancer ( 1 ). More than 90% of all thyroid cancers are differentiated thyroid cancers (DTC), including papillary thyroid cancer (PTC) and

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Tian Zhou School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China

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Dai-wei Zhao School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China

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Ning Ma School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China

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Xue-ying Zhu School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China

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Xing-hong Chen Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China

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Xue Luo Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China

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Song Chen School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China

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Qing-jun Gao Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China

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Introduction The incidence of thyroid cancer (THCA) ranks first among head and neck cancers ( 1 ). Thyroid cancer can be divided into four histological types: papillary thyroid carcinoma (PTC), follicular carcinoma, anaplastic carcinoma, and

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Yuntao Song Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Jiaxin Wang Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Yanli Zhu Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Pathology, Peking University Cancer Hospital and Institute, Beijing, China

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Guohui Xu Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Tianxiao Wang Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Bin Zhang Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education/Beijing, Department of Head and Neck Surgery, Peking University Cancer Hospital and Institute, Beijing, China

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Introduction The incidence-based mortality rates of thyroid cancer continued to increase over the past few decades, with papillary thyroid cancer (PTC) being the most common histology ( 1 ). Recurrent or persistent metastasis of the neck lymph

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C Sui Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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Q He Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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R Du Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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D Zhang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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F Li Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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G Dionigi Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University Hospital ‘G. Martino’, The University of Messina, Messina, Italy

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N Liang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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H Sun Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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dissected cervical nodes, however, a discrepancy may exist between the absolute number of positive nodes and the substantive extent of differentiated thyroid cancer (DTC) node metastasis ( 1 , 2 , 6 ). Therefore, the NR, defined as the absolute number of

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Luca Giovanella Clinic for Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Clinic for Nuclear Medicine, University Hospital of Zürich, Zürich, Switzerland

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Maria Luisa Garo Mathsly Research, Brescia and Vibo Valentia, Italy

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Domenico Albano Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy

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Rainer Görges Department of Nuclear Medicine, University Hospital of Essen, Essen, Germany

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Luca Ceriani Clinic for Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland
Faculty of Biomedical Sciences, Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland

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of patients with papillary thyroid cancer and number of patients with follicular thyroid cancer. Poorly differentiated or Hürthle or aggressive variants. Sample size included in Tg-DT calculation. Follow-up in years. Number of

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Mubashir Mulla Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK

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Klaus-Martin Schulte Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK
Department of Endocrine Surgery, King College London, King's Health Partners, King's College Hospital, Denmark Hill, London, SE5 9RS, UK

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Introduction Papillary thyroid cancer (PTC) is the most common thyroid cancer. Metastases from PTC most commonly involve the cervical lymph nodes (CLNs). The incidence of CLN metastases (CLNM) is reported between 30 and 80% (1, 2) . Some studies

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