Nancy J Olsen
Nancy J Olsen
Division of Rheumatology, Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, Milton S Hershey Medical Center, The Pennsylvania State University, Mail Code H044, 500 University Drive, Hershey, Pennsylvania 17033-0850, USA
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Ann L Benko
Ann L Benko
Division of Rheumatology, Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, Milton S Hershey Medical Center, The Pennsylvania State University, Mail Code H044, 500 University Drive, Hershey, Pennsylvania 17033-0850, USA
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William J Kovacs
William J Kovacs
Division of Rheumatology, Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, Milton S Hershey Medical Center, The Pennsylvania State University, Mail Code H044, 500 University Drive, Hershey, Pennsylvania 17033-0850, USA
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Introduction Androgenic gonadal steroid hormones exert effects on both human autoimmune disease and the corresponding animal models. In an experimental mouse model of human systemic lupus erythematosus, females acquire fatal renal disease while
Anette Lundqvist
Anette Lundqvist
Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden
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Herbert Sandström
Herbert Sandström
Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden
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Torbjörn Bäckström
Torbjörn Bäckström
Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden
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energy homeostasis to modulate appetite in response to signals by blood-borne hormones and peptides from adipose tissue and gastrointestinal organs in a complicated process ( 13 , 40 ). Allopregnanolone is not a classical steroid hormone and does not
Corina Verónica Sasso
Corina Verónica Sasso
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
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Flavia Eliana Santiano
Flavia Eliana Santiano
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
Universidad de Mendoza, Mendoza, Argentina
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Universidad de Mendoza, Mendoza, Argentina
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Fiorella Campo Verde Arboccó
Fiorella Campo Verde Arboccó
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
Universidad de Mendoza, Mendoza, Argentina
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Universidad de Mendoza, Mendoza, Argentina
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Leila Ester Zyla
Leila Ester Zyla
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
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Silvana Noemí Semino
Silvana Noemí Semino
Hospital Universitario, Universidad Nacional de Cuyo, Mendoza, Argentina
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Martin Eduardo Guerrero-Gimenez
Martin Eduardo Guerrero-Gimenez
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
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Virginia Pistone Creydt
Virginia Pistone Creydt
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
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Constanza Matilde López Fontana
Constanza Matilde López Fontana
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
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Rubén Walter Carón
Rubén Walter Carón
Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), CCT-Mendoza CONICET, Mendoza, Argentina
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40%, respectively, higher in men than in women ( 1 ). Since the Women’s Health Initiative in 1991 ( 2 ), and several epidemiological studies, the ovarian steroids were considered protectors against the development of CRC. Different studies in animal
Maki Igarashi
Maki Igarashi
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Tadayuki Ayabe
Tadayuki Ayabe
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Kiwako Yamamoto-Hanada
Kiwako Yamamoto-Hanada
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
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Keiko Matsubara
Keiko Matsubara
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Hatoko Sasaki
Hatoko Sasaki
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
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Mayako Saito-Abe
Mayako Saito-Abe
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
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Miori Sato
Miori Sato
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
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Nathan Mise
Nathan Mise
Department of Environmental and Preventive Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
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Akihiko Ikegami
Akihiko Ikegami
Department of Environmental and Preventive Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
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Masayuki Shimono
Masayuki Shimono
Regional Center for Pilot Study of Japan Environment and Children’s Study, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
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Reiko Suga
Reiko Suga
Regional Center for Pilot Study of Japan Environment and Children’s Study, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
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Shouichi Ohga
Shouichi Ohga
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
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Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
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Masafumi Sanefuji
Masafumi Sanefuji
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
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Research Center for Environment and Developmental Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan
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Masako Oda
Masako Oda
Department of Public Health, Faculty of Life Sciences, Kumamoto University, Chuo-ku, Kumamoto, Japan
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Hiroshi Mitsubuchi
Hiroshi Mitsubuchi
Department of Neonatology, Kumamoto University Hospital, Chuo-ku, Kumamoto, Japan
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Takehiro Michikawa
Takehiro Michikawa
Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
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Shin Yamazaki
Shin Yamazaki
Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
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Shoji Nakayama
Shoji Nakayama
Japan Environment and Children’s Study Programme Office, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
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Yukihiro Ohya
Yukihiro Ohya
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
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Maki Fukami
Maki Fukami
Medical Support Center for Japan Environmental and Children’s Study, National Center for Child Health and Development, Setagaya, Tokyo, Japan
Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan
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years before developing physical signs, children undergo conspicuous changes in the blood levels of sex hormones. Usually, an increase in circulating adrenal steroids (‘adrenarche’) occurs at 7 or 8 years of age in children of both sexes ( 1 , 2 , 3
M Boering
M Boering
Isala, Diabetes Centre, Zwolle, The Netherlands
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P R van Dijk
P R van Dijk
Isala, Diabetes Centre, Zwolle, The Netherlands
Isala, Department of Internal Medicine, Zwolle, The Netherlands
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Isala, Department of Internal Medicine, Zwolle, The Netherlands
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S J J Logtenberg
S J J Logtenberg
Diakonessenhuis, Department of Internal Medicine, Utrecht, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
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K H Groenier
K H Groenier
Isala, Diabetes Centre, Zwolle, The Netherlands
Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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B H R Wolffenbuttel
B H R Wolffenbuttel
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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R O B Gans
R O B Gans
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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N Kleefstra
N Kleefstra
Isala, Diabetes Centre, Zwolle, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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H J G Bilo
H J G Bilo
Isala, Diabetes Centre, Zwolle, The Netherlands
Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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suggested to influence several extra-glycemic, metabolic, and endocrinological parameters, such as the sex hormone-binding globulin (SHBG). SHBG is a glycoprotein produced in the liver, which regulates the bioavailability of sex steroids for target tissues
Carlo Cinque
Carlo Cinque
Fondazione Ethoikos, Radicondoli, Italy
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy
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Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy
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Manuela Zinni
Manuela Zinni
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy
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Anna Rita Zuena
Anna Rita Zuena
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy
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Chiara Giuli
Chiara Giuli
Fondazione Ethoikos, Radicondoli, Italy
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Sebastiano G Alemà
Sebastiano G Alemà
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy
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Assia Catalani
Assia Catalani
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy
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Paola Casolini
Paola Casolini
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy
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Roberto Cozzolino
Roberto Cozzolino
Fondazione Ethoikos, Radicondoli, Italy
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( 1 ). For ethical and experimental reasons, a growing number of researchers tend to use non-invasive techniques for steroid hormone level assessments in wild and captive vertebrates ( 2 , 3 , 4 , 5 ). Among the non-invasive matrices, the faeces are
Yao Chen
Yao Chen
Hangzhou Fuyang Women and Children Hospital, Hangzhou, China
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Shu-ying Fang
Shu-ying Fang
Hangzhou Fuyang Women and Children Hospital, Hangzhou, China
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steroid biosynthesis and action, gonadotropic secretion and action, folliculogenesis, weight and energy regulation and insulin action ( 13 ). In this review, we aimed to provide an overview of the main genetic polymorphisms that were found or
Masatada Watanabe
Masatada Watanabe
Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan
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Shuji Ohno
Shuji Ohno
Division of Research for Pharmacy Students Education, Hoshi University, Shinagawa, Tokyo, Japan
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Hiroshi Wachi
Hiroshi Wachi
Laboratory of Tissue Regeneration, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa, Tokyo, Japan
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Introduction Sex steroids are important for the maintenance of healthy skin. Based on studies on older women, sex steroids in skin regulate the collagen content and the synthesis of hyaluronic acid ( 1 ). Estrogen-conjugated cream applied to
Manjeetkaur Sehemby
Manjeetkaur Sehemby
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Prachi Bansal
Prachi Bansal
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Vijaya Sarathi
Vijaya Sarathi
Department of Endocrinology, Narayana Medical College, Nellore, Andhra Pradesh, India
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Ashwini Kolhe
Ashwini Kolhe
Department of Pathology, Seth GS Medical college and KEM Hospital, Parel, Mumbai, India
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Kanchan Kothari
Kanchan Kothari
Department of Pathology, Seth GS Medical college and KEM Hospital, Parel, Mumbai, India
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Swati Jadhav-Ramteke
Swati Jadhav-Ramteke
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Anurag R Lila
Anurag R Lila
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Tushar Bandgar
Tushar Bandgar
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India
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women compared to only two of the eleven premenopausal women ( P = 0.08). There was no significant correlation between any other clinical features of HA. Figure 1 Percentage of patients with each symptom. Figure 2 Steroid cell tumor
Emanuelle Nunes-Souza
Emanuelle Nunes-Souza
Pelé Pequeno Príncipe Research Institute, Água Verde, Curitiba, Parana, Brazil
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Mônica Evelise Silveira
Mônica Evelise Silveira
Laboratório Central de Análises Clínicas, Hospital de Clínicas, Universidade Federal do Paraná, Centro, Curitiba, Paraná, Brazil
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Monalisa Castilho Mendes
Monalisa Castilho Mendes
Pelé Pequeno Príncipe Research Institute, Água Verde, Curitiba, Parana, Brazil
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Seigo Nagashima
Seigo Nagashima
Serviço de Anatomia Patológica, Hospital de Clínicas, Universidade Federal do Paraná, General Carneiro, Alto da Glória, Curitiba, Parana, Brazil
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Caroline Busatta Vaz de Paula
Caroline Busatta Vaz de Paula
Serviço de Anatomia Patológica, Hospital de Clínicas, Universidade Federal do Paraná, General Carneiro, Alto da Glória, Curitiba, Parana, Brazil
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Guilherme Guilherme Vieira Cavalcante da Silva
Guilherme Guilherme Vieira Cavalcante da Silva
Serviço de Anatomia Patológica, Hospital de Clínicas, Universidade Federal do Paraná, General Carneiro, Alto da Glória, Curitiba, Parana, Brazil
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Giovanna Silva Barbosa
Giovanna Silva Barbosa
Serviço de Anatomia Patológica, Hospital de Clínicas, Universidade Federal do Paraná, General Carneiro, Alto da Glória, Curitiba, Parana, Brazil
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Julia Belgrowicz Martins
Julia Belgrowicz Martins
Pelé Pequeno Príncipe Research Institute, Água Verde, Curitiba, Parana, Brazil
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
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Lúcia de Noronha
Lúcia de Noronha
Serviço de Anatomia Patológica, Hospital de Clínicas, Universidade Federal do Paraná, General Carneiro, Alto da Glória, Curitiba, Parana, Brazil
Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Departamento de Medicina, PUC-PR, Prado Velho, Curitiba, Parana, Brazil
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Luana Lenzi
Luana Lenzi
Departamento de Análises Clínicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
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José Renato Sales Barbosa
José Renato Sales Barbosa
Pelé Pequeno Príncipe Research Institute, Água Verde, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Rayssa Danilow Fachin Donin
Rayssa Danilow Fachin Donin
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Juliana Ferreira de Moura
Juliana Ferreira de Moura
Pós Graduação em Microbiologia, Parasitologia e Patologia, Departamento de Patologia Básica – UFPR, Curitiba, Brazil
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Gislaine Custódio
Gislaine Custódio
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Laboratório Central de Análises Clínicas, Hospital de Clínicas, Universidade Federal do Paraná, Centro, Curitiba, Paraná, Brazil
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Laboratório Central de Análises Clínicas, Hospital de Clínicas, Universidade Federal do Paraná, Centro, Curitiba, Paraná, Brazil
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Cleber Machado-Souza
Cleber Machado-Souza
Pelé Pequeno Príncipe Research Institute, Água Verde, Curitiba, Parana, Brazil
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
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Enzo Lalli
Enzo Lalli
Institut de Pharmacologie Moléculaire et Cellulaire CNRS, Sophia Antipolis, Valbonne, France
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Bonald Cavalcante de Figueiredo
Bonald Cavalcante de Figueiredo
Pelé Pequeno Príncipe Research Institute, Água Verde, Curitiba, Parana, Brazil
Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Departamento de Saúde Coletiva, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
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Faculdades Pequeno Príncipe, Rebouças, Curitiba, Parana, Brazil
Centro de Genética Molecular e Pesquisa do Câncer em Crianças (CEGEMPAC) at Universidade Federal do Paraná, Agostinho Leão Jr., Glória, Curitiba, Parana, Brazil
Departamento de Saúde Coletiva, Universidade Federal do Paraná, Curitiba, Paraná, Brazil
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major steroid products in the fetal zone, namely DHEA and DHEA sulfate (DHEAS), which serve as estrogen precursors essential for the maintenance of pregnancy ( 5 , 6 ). Onset of zonal differential steroidogenic activity and strong remodeling of the
