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of the observed magnitude and duration could have detrimental metabolic effects. So far, studies on meal-induced cortisol in obese subjects were scarce, and results were heterogeneous. In an observational study, obesity was associated with a poor
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of reproductive biology and urology. In mammals, this gland produces and secretes essential components for the protection and viability of spermatozoa. In middle age or later, men become highly prone to developing prostatic hyperplasia and/or cancer
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National Institute for Health Research (NIHR) Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London, UK
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, 11.3, 13.2) and 473 girls with a median age 12.3 years (11.1, 13.2). Approximately 2 years later (T2) between February 2017 and July 2018, 563 boys with a median age of 14.3 years (13.4, 15.8) and 422 girls with a median age of 14.3 years (13.4, 15
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.e., ≥10 mm) may develop from any of the waves that emerge during the IOI. In women of reproductive age, only one wave of the IOI has been shown to result in ovulation. In comparison, as women approach menopause, the waves preceding the late follicular
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to adjust the dosage correctly. Mitotane is associated with various side effects that are always dose-dependent and are related to its pharmacodynamic properties in some cases (modification of lipid profile, hepatic cytolysis, cholestasis, adrenal
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Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Department of Clinical, Neuro, and Developmental Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat, Amsterdam, The Netherlands
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) and the reported congruent effects of X and Y chromosomes on the proportional size of cortical brain systems involved in adaptive functioning ( 3 ). However, research has been fueled by an increasing awareness that studying gene
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compared with concentrations in the same women before pregnancy (14, 15) . As pregnancy progressed, plasma IGF2 returned to pre-conception concentrations (14) or increased to ∼10% above pre-conception concentrations (15) . In addition to effects on
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route of administration, the varied systemic side effects of oral or intravenous glucocorticoids should be minimized, in particular the suppression of the hypothalamic–pituitary–adrenal (HPA) axis or the inhibition of osteoblast function. Even after
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in women with CAIS has developed through observations voiced from user groups, particularly women who experienced late gonadectomy. Unlike younger age groups, those who have gained a sense of a ‘testosterone milieu’ after gonadarche are in a good
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into later life through recognised epigenetic effects in utero ( 27 , 28 ). Thus, ensuring repletion in all women of childbearing age would help to reduce later health risks, and by reducing later health care costs, should prove to be a cost