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period is typically in-between paediatric and adult doses, with adjustment primarily based on serum IGF-I, just as in adult patients ( 13 ). Insulin-like growth factor-binding protein 3 (IGFBP-3), acid-labile subunit (ALS) and bioactive IGF
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(5) , the levels of growth hormone (GH) (9) , as well as the duration of acromegaly and duration of exposure to elevated GH levels (9, 10) . However, other authors have found no differences in GH levels and insulin-like growth factor 1 (IGF1) levels
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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.06 −38 253.37 0.00 Leptin LEP 64.69 0.10 −642.51 0.00 Insulin-like growth factor 2 IGF2 94.15 0.17 −549.78 0.00 Brain expressed, X-linked 1 BEX1 369.40 1.30 −283.28 0.00 Prostaglandin D2 synthase 21 kDa (brain) PTGDS 136.49 0.62 −219.06 0.00 Collagen
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growth hormone/insulin-like growth factor-1 (GH/IGF-1) system. IGF-1 levels were reported to be positively associated with height ( 30 , 31 ). The kidney is a significant source of IGF-1 synthesis, some of which is released into circulation. In addition
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Endocrinology and Nephrology, Nordsjællands University Hospital, Hillerød, Denmark
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Steno Diabetes Center Copenhagen, Gentofte, Denmark
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resorption ( 6 ). Finally, we studied the expression of insulin receptors ( INSR ), insulin-like growth factor 1 receptors ( IGF1R ), and insulin-like growth factor 2 receptors ( IGF2R ) in the parathyroid gland on formalin fixed, paraffin embedded (FFPE
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Salvatori R Levine MA . Effect of severe growth hormone (GH) deficiency due to a mutation in the GH releasing hormone receptor on insulin-like growth factors (IGF-1), IGF-binding proteins, and ternary complex formation throughout life . Journal of
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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shown that insulin and insulin-like growth factor (IGF) are involved in the development and progression of malignancies ( 9 , 10 ). Insulin has been reported to be associated with an increased risk of several cancer sites, such as the liver, pancreas
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Introduction Growth hormone (GH) and its principal mediator insulin-like growth factor 1 (IGF1) have important effects not only on the acquisition of normal body size, but also on metabolic and cardiovascular (CV) status (1) . GH and IGF1 have
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insulin-like growth factor-1 receptor (IGF-1R) could also be co-activated with the IR-β by insulin ( 34 ), we then analyzed the expression of IGF-1R and found that the protein levels of IGF-1R were significantly reduced in the skeletal muscle of male CG
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). The exceptions when re-testing is generally not required are in patients with genetic/congenital defects, irreversible hypothalamic–pituitary lesions, and in those with panhypopituitarism and low serum insulin-like growth factor 1 (IGF1) levels ( 4