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Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp and Evgeni Levin

/L) 1.45 0.65 1.25 0.69 HOMA-IR 4.53 1.95 4.36 2.18 BMI, body mass index; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment-insulin resistance; LDL, low

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Ahmet Uçar, Nurçin Saka, Firdevs Baş, Nihal Hatipoğlu, Rüveyde Bundak and Feyza Darendeliler

glucose (IFG) (22) . To determine insulin sensitivity (IS), homeostasis model assessment of insulin resistance (HOMA-IR) (fasting glucose (mg/dl)×insulin (mU/l)/405) (23) and IS index (ISI comp ) (Matsuda index=10 000/square root of ((fasting glucose

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Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan and Chuang Guo

Introduction Type 2 diabetes mellitus (T2DM) is becoming one of the most pressing health issues facing society. Although T2DM is well described in terms of its hallmarks, namely insulin resistance and chronic hyperglycemia, the factors

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Signe Frøssing, Malin Nylander, Caroline Kistorp, Sven O Skouby and Jens Faber

Introduction Women with polycystic ovary syndrome (PCOS) are challenged with a metabolic aspect of the syndrome as they have increased prevalence of overweight with central obesity and insulin resistance. They present with an accumulation of

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Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen and Anders Juul

). Serious adverse health effects have been associated with high phthalate exposure such as alteration in reproductive development and increased risks of insulin resistance and obesity in human adults ( 8 , 9 , 10 , 11 , 12 ). Importantly, children may be

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Chenghao Piao, Xiaojie Wang, Shiqiao Peng, Xinyu Guo, Hui Zhao, Li He, Yan Zeng, Fan Zhang, Kewen Zhu and Yiwei Wang

foetus for development ( 5 ). The need for maternal insulin is an elevated result of gestational insulin resistance, which is impacted by attenuated food intake and placental hormone production. Consequently, the sizes of pancreatic β cells are enhanced

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Karolien Van De Maele, Jean De Schepper, Jesse Vanbesien, Monique Van Helvoirt, Ann De Guchtenaere and Inge Gies

directly by a direct vitamin D receptor-dependent inhibition of the critical molecular components of adipogenesis, as well indirectly by inducing insulin resistance and elevated PTH concentrations. Therefore, the main aim of our study is to investigate

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Teresa Vilariño-García, Antonio Pérez-Pérez, Esther Santamaría-López, Nicolás Prados, Manuel Fernández-Sánchez and Víctor Sánchez-Margalet

soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens . Fertility and Sterility 2006 85 1441 – 1447 . ( ) 24

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Karim Gariani, Geneviève Drifte, Irène Dunn-Siegrist, Jérôme Pugin and François R Jornayvaz

-activated receptor α (PPARα) and PPARγ respectively (1, 6) . FGF21 has emerged as a key regulator in the metabolism of glucose and lipids (6, 7, 8) . FGF21 may have a potential role as a therapeutic agent for conditions associated with insulin resistance as it has

Open access

Angela Köninger, Philippos Edimiris, Laura Koch, Antje Enekwe, Claudia Lamina, Sabine Kasimir-Bauer, Rainer Kimmig and Hans Dieplinger

parameters of oxidative stress such as ‘advanced glycosylation end products’ correlated strongly with anovulation, follicle number, and concentrations of anti-Müllerian hormone (AMH) in patients with PCOS (3) . Although insulin resistance (IR) plays an