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the epidemiology of SH in children and pre-adolescents are scarce; however, the prevalence of SH in this population is estimated to be slightly lower than 2% ( 4 ). SH can have autoimmune or non-autoimmune origins. It can be distinguished between
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Quebec – Canada ( 3 , 4 , 5 ). The strong influence of highly prevalent founder SDHx mutations on the national epidemiology of PPGL is well typified by the experience of the Netherlands ( 6 ). In a large national survey ( n = 1045 DNA samples
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Deutsches Herzzentrum München, Technische Universität München, DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
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Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany
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/active) and education in years ( 36 ). Further, we used estimated glomerular filtration rate (eGFR) which was calculated from serum creatinine (isotope dilution mass spectrometry-calibrated) with the ‘Chronic Kidney Disease Epidemiology Collaboration’ (CKD
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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Institute of Epidemiology and Medical Biometry, ZIBMT, Ulm University, Ulm, Germany
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software (clinical data managers, Institute of Epidemiology and Medical Biometry (ZIBMT), Ulm University, Ulm, Germany). The authors wish to thank all centers contributing to this analysis: Augsburg IV. Med. Uni-Klinik, Bad Mergentheim
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, which were developed from the Surveillance, Epidemiology, and End Results (SEER) database comprising more than 1000 ACC patients, have shown promising predictive accuracy in American patients ( 5 , 7 , 8 ). Recently, a scoring system known as the S
Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
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prevalence of NEN are steadily increasing ( 1 , 2 ). According to the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database, the incidence rate of NEN has increased from 1.09 per 100,000 people in 1973 to 6.98 per 100
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Pediatric Endocrinology Unit, Department of Women's and Children's Health, Padua University Hospital, Padova, Italy
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females than in males if compared to GD and its incidence rises with age, in particular from 60 years of age ( 7 ). It is well known that iodine viability influences the epidemiology of thyroid diseases, with hypothyroidism dominating in areas of high
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e8 – e21 . ( https://doi.org/10.1016/S1470-2045(13)70362-0 ) 10.1016/S1470-2045(13)70362-0) 2 Sandvik OM Soreide K Gudlaugsson E Kvaloy JT Soreide JA. Epidemiology and classification of gastroenteropancreatic neuroendocrine neoplasms using
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Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
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The excess risk of cancer observed in patients with type 2 diabetes (T2DM) may have been influenced by detection bias. The aim of this study was to examine the real association by evaluating time-varying site-specific cancer risks in newly diagnosed T2DM patients. A total of 51,324 registered cancer-free individuals newly diagnosed with T2DM between 2004 and 2014 were linked with the Shanghai Cancer Registry and the Vital Statistics through September 2015. A total of 2920 primary, invasive cancer cases were identified during 325,354 person-years period. Within 1 year following diabetes onset, participants with T2DM had higher risks of total, lung and rectal cancer in men and total, liver, pancreas, thyroid, breast and uteri cancer in women. Thereafter the incidence for overall cancer decreased and then increased along with follow-up time, with the upward trend varying by cancer, suggesting potential detection bias. After the initial 1-year period, standardized incidence ratios (SIR) and 95% CIs for overall cancer were 0.80 (95% CI 0.76–0.85) in men and 0.93 (95% CI 0.88–0.99) in women, but a higher risk of breast and thyroid cancers were observed in women, with SIR and 95% CI being 1.13 (1.01, 1.28) and 1.37 (1.11, 1.63), respectively. Our results suggest that T2DM patients are at higher risk of certain cancers; this risk particularly increases shortly after diabetes diagnosis, which is likely to be due to detection bias caused by increased ascertainment. Prevention of female breast and thyroid cancers should be paid attention in Chinese individuals with T2DM.
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Stapleton PL Lampe JW Farin FM , et al . Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women . Cancer Epidemiology, Biomarkers and Prevention 2004 94 – 101