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(decreased muscle strength and painful joints), neuropsychiatric symptoms (e.g. anxiety, depression/mood change, fatigue, and memory problems), and gastrointestinal discomfort, including constipation ( 1 , 2 ). All of these factors may potentially affect the
DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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of the developing and mature brain ( 5 ). CRH system dysregulation is critically involved in stress-related disorders: psychiatric conditions (i.e. depression, anxiety, addictions), neuroendocrinological alterations and inflammation and has been
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Depression, anxiety Depression Anxiety, nervousness, restlessness, attention and concentrating difficulties Hair loss + + +/− Alopecia Infertility/missed periods +/+ +/+ +/+ Miscarriage + + + Increased other
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%) Antihypertensives ACE Inhibitors 8 (27%) Betablockers 5 (17%) Depression 6 (20%) Anticonvulsants 3 (10%) Diabetes mellitus 3 (10%) Antidepressants 2 (7%) Dyslipidemia 2 (7%) NSAID 2 (7%) Epilepsy 3 (10%) Oral
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Department of Endocrinology, Department of Public Health, Department of Cancer Research and Molecular Medicine, Department of Medical Biochemistry, St Olavs Hospital, Trondheim University Hospital, P O Box 3250 Sluppen, N-7006 Trondheim, Norway
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, and depression, may cause physiological hypercortisolism and false-positive DST results (1) . Therefore, the association of dexamethasone with cortisol levels may differ between the general population and patients with suspected Cushing's syndrome. We
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
Mount Auburn Hospital, Harvard Medical School Teaching Hospital, Cambridge, Massachusetts, USA
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medical and/or family history of psychiatric disorders, detailed psychiatric evaluation was performed using the Hamilton scale for depression and anxiety as well as the Hospital Anxiety and Depression Score (HADS) ( 20 ). For patients referred from
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy
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Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele, Rome, Italy
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Medical Department Pronokal Group, Barcelona, Spain
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up to 3 months preceding the start of the trial, severe depression or other psychiatric disorder, alcohol and drug abuse, severe hepatic insufficiency, any level of renal insufficiency or calculosis of the urinary tract, gout, malignancy, previous
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conditions Humans Major depression (MD), schizophrenia, bipolar disorderPost-traumatic stress disorder (PTSD), general anxiety disorder (GAD) Hippocampus, prefrontal-, temporal- and entorhinal cortex, PBMCs, lymphocytes Reduced N.D Diminished GC
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depression ( 21 ), measured between 1 and 5 years post injury. In a consecutive cohort of 78 men with TBI, a prevalence of posttraumatic hypogonadotropic hypogonadism was found in 44% of patients during the first year post injury ( 22 ). Hypogonadotropic
Faculty of Medicine, University of Oslo, Oslo, Norway
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Centre of Excellence-HTH, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
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Faculty of Medicine, University of Oslo, Oslo, Norway
Metabolic and Renal Research Group, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway
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), Montgomery-Åsberg depression rating scale ( 12 ), Stanford Integrated Psychosocial Assessment for Transplantation ( 13 ) and psychometric instruments to assess personality, burden of disease, and quality of life ( 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21