Huguette S Brink
Huguette S Brink
Department of Endocrinology, Maasstad Hospital, Rotterdam, The Netherlands
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Aart Jan van der Lely
Aart Jan van der Lely
Department of Endocrinology, Erasmus University MC, Rotterdam, The Netherlands
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Joke van der Linden
Joke van der Linden
Department of Endocrinology, Maasstad Hospital, Rotterdam, The Netherlands
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developing GD ( 25 ). The global increase in GD is largely attributed to the ongoing obesity pandemic ( 26 ). Obesity is characterized by altered production of proinflammatory cytokines by adipocytes causing a state of chronic low-grade inflammation ( 27
Esben S Lauritzen
Esben S Lauritzen
The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Nikolaj Rittig
Nikolaj Rittig
The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Ermina Bach
Ermina Bach
The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Niels Møller
Niels Møller
The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Mette Bjerre
Mette Bjerre
The Medical Research Laboratories, Institute of Clinical Research, Aarhus University, Aarhus C, Denmark
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/mL) during the two conditions. The Y -axis is logarithmic scaled. Points are medians and error bars are ranges. * P < 0.05. Table 1 list extracted vital parameters and cytokine response to LPS; for the full metabolic response, see the primary
A Chinoy
A Chinoy
Royal Manchester Children’s Hospital, Manchester, UK
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M Skae
M Skae
Royal Manchester Children’s Hospital, Manchester, UK
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A Babiker
A Babiker
King Abdullah Specialized Children’s Hospital, Riyadh, Saudi Arabia
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D Kendall
D Kendall
Royal Preston Hospital, Preston, UK
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M Z Mughal
M Z Mughal
Royal Manchester Children’s Hospital, Manchester, UK
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R Padidela
R Padidela
Royal Manchester Children’s Hospital, Manchester, UK
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over-treatment. Inflammatory cytokines may also have a role in this phenomenon. Interleukin (IL)-1β and IL-6 are both pro-inflammatory cytokines whose levels have been shown to increase within hours of infection in crticially ill patients and are
Bo Zhu
Bo Zhu
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Yumei Chen
Yumei Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Fang Xu
Fang Xu
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xiaolu Shen
Xiaolu Shen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xuanyu Chen
Xuanyu Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Jieqiang Lv
Jieqiang Lv
Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Songying Zhang
Songying Zhang
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
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treatment: Control, no treatment; Cytokine cocktail (CC, 10 ng/mL IL-1β, 100 ng/mL IFN-γ, and 25 ng/mL TNF-α) treatment as positive control of ER dysfunction; and three TE treatments with the concentration of 0.01, 0.1 and 1 μg/mL. The islets and INS-1 cells
Aditya Dutta
Aditya Dutta
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Ganesh Jevalikar
Ganesh Jevalikar
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Rutuja Sharma
Rutuja Sharma
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Khalid J Farooqui
Khalid J Farooqui
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Shama Mahendru
Shama Mahendru
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Arun Dewan
Arun Dewan
Institute of Internal Medicine, Max Healthcare, Saket, New Delhi, India
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Sandeep Bhudiraja
Sandeep Bhudiraja
Institute of Internal Medicine, Max Healthcare, Saket, New Delhi, India
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Ambrish Mithal
Ambrish Mithal
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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indirect effects (due to pro-inflammatory cytokine storm) on several endocrine organs and their axes have been elucidated ( 1 , 2 , 3 ). Hypothalamic–pituitary–thyroid (HPT) axis is an essential endocrine axis that regulates energy expenditure and
Clara Lundetoft Clausen
Clara Lundetoft Clausen
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
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Trine Holm Johannsen
Trine Holm Johannsen
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Niels Erik Skakkebæk
Niels Erik Skakkebæk
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Hanne Frederiksen
Hanne Frederiksen
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Camilla Koch Ryrsø
Camilla Koch Ryrsø
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Arnold Matovu Dungu
Arnold Matovu Dungu
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
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Maria Hein Hegelund
Maria Hein Hegelund
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
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Daniel Faurholt-Jepsen
Daniel Faurholt-Jepsen
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Rikke Krogh-Madsen
Rikke Krogh-Madsen
Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
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Birgitte Lindegaard
Birgitte Lindegaard
Department of Pulmonary and Infectious Diseases, Copenhagen University Hospital – Nordsjælland, Hillerød, Denmark
Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Centre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Allan Linneberg
Allan Linneberg
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Line Lund Kårhus
Line Lund Kårhus
Center for Clinical Research and Prevention, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Thomas Benfield
Thomas Benfield
Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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) and interleukin (IL)-6. Animal and human studies have shown association between low testosterone concentrations and higher pro-inflammatory cytokines (e.g. IL-6) and lower anti-inflammatory cytokines (e.g. IL-10), and thus, low testosterone
Tian Zhou
Tian Zhou
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Dai-wei Zhao
Dai-wei Zhao
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Ning Ma
Ning Ma
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Xue-ying Zhu
Xue-ying Zhu
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Xing-hong Chen
Xing-hong Chen
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Xue Luo
Xue Luo
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Song Chen
Song Chen
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Qing-jun Gao
Qing-jun Gao
Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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mainly enriched in allograft rejection, chemokine signaling pathway, and cytokine receptor interaction. After considering the results of the GSEA, it was concluded that FOXP4 might be highly correlated with immune and inflammation responses, suggesting
Arno Téblick
Arno Téblick
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Lies Langouche
Lies Langouche
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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Greet Van den Berghe
Greet Van den Berghe
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
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hormonal ‘fight or flight’ state is activated by the abundancy of released proinflammatory cytokines, the overwhelming activation of sensory neurons, the release of catecholamines and/or the presence of pathogens in the bloodstream ( 5 , 6 ). Further
Elizabeth Micks
Elizabeth Micks
Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA
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Greta B Raglan
Greta B Raglan
Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA
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Jay Schulkin
Jay Schulkin
Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA
Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA
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Department of Obstetrics and Gynecology, Department of Research, University of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USA
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, which are known to promote labor (56, 57) . NFκB is stimulated by pro-inflammatory cytokines including tumor necrosis factor alpha (TNFα), lipopolysaccharides, and interleukin 1 beta (IL1β). Conversely, NFκB promotes the synthesis of cytokines, and
Lena-Maria Levin
Lena-Maria Levin
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
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Henry Völzke
Henry Völzke
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
DZD (German Center for Diabetes Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
DZD (German Center for Diabetes Research), Greifswald, Germany
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Markus M Lerch
Markus M Lerch
Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
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Jens-Peter Kühn
Jens-Peter Kühn
Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
Institute and Policlinic for Radiology and Interventional Radiology, University Hospital, Carl-Gustav-Carus University Dresden, Dresden, Germany
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Institute and Policlinic for Radiology and Interventional Radiology, University Hospital, Carl-Gustav-Carus University Dresden, Dresden, Germany
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Matthias Nauck
Matthias Nauck
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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Nele Friedrich
Nele Friedrich
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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Stephanie Zylla
Stephanie Zylla
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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DZHK (German Centre for Cardiovascular Research), Greifswald, Germany
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influencing an excessive production of Th1 cytokines or generating reactive oxygen species ( 35 ). Furthermore, circulating chemerin has been observed to be positively correlated with macrophages ( 7 ) and a number of pro-inflammatory cytokines ( 33 ). In
