Department of Neuroscience DNS, University of Padova, Padova, Italy
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Nuclear Medicine Unit, Department of Medicine – DIMED, University-Hospital of Padova, Padova, Italy
Padova Neuroscience Center PNC, University of Padova, Padova, Italy
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Department of Mathematics ‘Tullio Levi-Civita’ DM, University of Padova, Padova, Italy
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impaired results using first-line screening tests: elevation of 24-h urinary free cortisol (UFC), absent serum cortisol suppression (<50 nmol/L) after overnight 1 mg dexamethasone suppression test (DST) and loss of circadian salivary cortisol rhythm. The
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% reduction in cortisol exposure, as estimated by the area under the curve ( 31 ). Therefore, the beneficial effects of DR-HC might be explained by a reduction in cortisol exposure, meaning more physiological circadian fluctuations of cortisol concentrations
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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model of arthritis (STA) ( P < 0.01). Serum ACTH and corticosterone were measured at 12:00 h, which corresponds to the nadir of the rodent circadian glucocorticoid production rhythm. Levels of ACTH and corticosterone were not found to be
Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA
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University of Chicago, Chicago, Illinois, USA
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and corrected energy expenditures, activity or food consumption ( Fig. 3A – F ). Thus, in the setting of an HFHSD, TF exposure does not alter fuel preference, energy expenditure or metabolic circadian rhythms. Figure 3 Metabolic cage analyses on
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–pituitary–adrenal axis (HPA): basal cortisol level <3 μg/dL indicated impaired HPA function while the basal cortisol level >15 μg/dL excluded it. If basal cortisol levels ranged from 3 to 15 μg/dL, the circadian rhythm of adrenocorticotropic hormone and cortisol (08
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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problem may be caused by decreased physical activity ( 8 , 39 ) or disturbance of the circadian rhythm due to visual impairment ( 7 ), or more likely, confounded by tumor location and hypothalamic involvement ( 40 ). Larger cohorts in future studies are
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA
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, 17 ). These include stress ( 18 ), disrupted circadian rhythms ( 19 ), the composition of the gut microbiome (bacterial diversity, balance of bacterial types and the particular species found) ( 20 , 21 ), air pollution from proximity to highways ( 22
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands
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had no information on the timing of antenatal corticosteroid treatment. Finally, for practical reasons related to the NICU setting we were not able to collect 24-h urine. However, young infants have not yet developed an adult-like circadian rhythm ( 29
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infused sc via miniosmotic infusion pumps (Alzet Cupertino, Model 2002) with either vehicle (0.154 M NaCl) or ACTH (Synacthen Ciba-Geigy, UK; 3 μg/day). At the end of the study, mice were killed by carbon dioxide at the nadir of the circadian cycle. Pairs
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signals. As the secretion capacity of leptin differs within different fat depots depending on the age, gender, and circadian rhythm, the likelihood that leptin represents a true ponderostat signal is low (79, 80, 81, 82) . Recent studies have demonstrated