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Doron Weinstein
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Rive Sarfstein
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Zvi Laron Department of Human Molecular Genetics and Biochemistry, Endocrinology and Diabetes Research Unit, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Haim Werner
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shown in Fig. 1 . (B and C) Effect of WT-AR on INSR promoter activity. C4-2 (B) and PC3 (C) cells were stably transfected with a WT-AR expression vector (WT-AR, two right bars in each panel) or an empty pcDNA3 vector for control purposes (pcDNA3, two

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-13-0086
Volume/Issue:
Volume 3: Issue 1
Open access
Ashley N Reeb Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Andrea Ziegler Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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Reigh-Yi Lin Department of Otolaryngology, Head and Neck Surgery, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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differentiation markers thyroglobulin ( TG ), thyroperoxidase ( TPO ), sodium-iodide symporter ( NIS ), or the receptor for thyroid stimulating hormone ( TSHR ) ( Fig. 1B ), confirming the dedifferentiated state of these human FTC cell lines. Figure 1

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0114
Volume/Issue:
Volume 5: Issue 2
Open access
Earn H Gan Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
Endocrine Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Wendy Robson Urology Unit, Freeman Hospital, Newcastle upon Tyne, UK

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Peter Murphy Urology Unit, Freeman Hospital, Newcastle upon Tyne, UK

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Robert Pickard Urology Unit, Freeman Hospital, Newcastle upon Tyne, UK
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK

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Simon Pearce Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
Endocrine Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Rachel Oldershaw Department of Musculoskeletal Biology, Institute of Ageing and Chronic disease, University of Liverpool, Liverpool, UK

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reached senescence after 3rd passage ( Fig. 1D (i)). The colony-forming unit fibroblast-like cells (CFU-F) were seen in the primary culture in either medium but cells seeded in MGPM exhibited a higher number of CFUs ( Fig. 1B (i) and (ii)). On average, 4

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0067
Volume/Issue:
Volume 7: Issue 5
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Zhandong Lei Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China
Department of Anatomy, Shanxi Medical University, Taiyuan, China

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Yunfei Chen Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Jin Wang Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Yan Zhang Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Wenjuan Shi Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Xuejiao Wang Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Dehai Xing Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Dongxue Li Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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Xiangying Jiao Key Laboratory of Cellular Physiology, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China

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level were measured. The results show that Txnip was almost undetectable of both protein and mRNA levels in Txnip KO mice ( Fig. 1A and B ). The proliferation ability of adult pancreatic β cells is normally very low; however, previous studies have

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-21-0641
Volume/Issue:
Volume 11: Issue 4
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Agnieszka Kosowska Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Enrique Gallego-Colon Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Wojciech Garczorz Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Agnieszka Kłych-Ratuszny Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Mohammad Reza F Aghdam Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Michał Woz´niak Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Andrzej Witek Department of Gynaecology and Obstetrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Agnieszka Wróblewska-Czech Department of Gynaecology and Obstetrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Anna Cygal Department of Gynaecology and Obstetrics, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Jerzy Wojnar Department of Internal Medicine and Oncological Chemotherapy, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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Tomasz Francuz Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland

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). Ovarian cancer cell lines were stimulated for 24 h with Exendin-4 (50 nM), Exendin-4 (50 nM) pre-treatment for 24 h and GLP-1 Antagonist 9–36 (50 nM) in both SKOV-3 (B) and CAOV-3 (C). Relative fluorescence units (RFU). Mean values ±  s.e.m. are shown. n

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0294
Volume/Issue:
Volume 6: Issue 8
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Jan-Bernd Stukenborg NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Kirsi Jahnukainen NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Marsida Hutka MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Rod T Mitchell MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
Edinburgh Royal Hospital for Sick Children, Edinburgh, UK

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hormone production based on data taken from normal human populations ( 19 , 20 , 21 ). Whilst gonadotrophins are undetectable during childhood, Sertoli cell-derived hormones Inhibin B and AMH remain detectable. Germ cells – development

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0382
Volume/Issue:
Volume 7: Issue 2
Open access
Zuyao Chen The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Xiaolin Zhong The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China
The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Weiqiang Tang The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Min Xia The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Chang Liu Department of Endocrinology and Metabolism, The First People's Hospital of Chenzhou, Chenzhou, China

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Yinping Guo The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Yan Yi The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Qingshan Jiang The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Xuyu Zu The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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Jing Zhong The First Affiliated Hospital, Institute of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, China

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. Materials and methods Cell lines The human PTC cell lines (B-CPAP, CTCC-400-0087; TPC-1, CTCC-400-0084), the human thyroid squamous cancer cell line (SW579, CTCC-400-0202), and the human ATC cell line (CAL-62, CTCC-400-0099) were purchased from Meisen

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Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0014
Volume/Issue:
Volume 12: Issue 5
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Hong Tang Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Xiaomei Jiang Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Yu Hua Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Heyue Li Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Chunlan Zhu Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Xiaobai Hao Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Minhui Yi Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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Linxia Li Departments of Gynaecology and Obstetrics Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

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was evaluated. To clarify its role, NEDD4L was overexpressed in KGN cells. qRT-PCR and western blotting were used to confirm the effectiveness of NEDD4L-OE ( Fig. 2A and B ). The CCK-8 assay and FDA staining were used to determine the cell viability

Article Type:
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Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-22-0459
Volume/Issue:
Volume 12: Issue 4
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Jintao Hu Department of Neurosurgery, Xinqiao Hospital, The Army Medical University, Chongqing, China

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Qingbo Chen Department of Neurosurgery, Xinqiao Hospital, The Army Medical University, Chongqing, China

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Xiao Ding Department of Neurosurgery, Xinqiao Hospital, The Army Medical University, Chongqing, China

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Xin Zheng Department of Neurosurgery, Xinqiao Hospital, The Army Medical University, Chongqing, China

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Xuefeng Tang Department of Pathology, Xinqiao Hospital, The Army Medical University, Chongqing, China

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Song Li Department of Neurosurgery, Xinqiao Hospital, The Army Medical University, Chongqing, China

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Hui Yang Department of Neurosurgery, Xinqiao Hospital, The Army Medical University, Chongqing, China

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proliferation of MMQ and AtT20 cells at 64% and 20%, respectively ( Fig. 1A and B ). Flow cytometric apoptosis assay revealed that Gln withdrawal induced apoptosis in MMQ cells but had no significant effect on GH3 and AtT20 cells ( Fig. 1C ). Figure 1 PA

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0515
Volume/Issue:
Volume 9: Issue 3
Open access
Joanna Klubo-Gwiezdzinska National Institute of Health, NIDDK, Office 10 Center Drive, Bethesda, Maryland, USA
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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John Costello Jr Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Kirk Jensen Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Aneeta Patel Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Rok Tkavc Department of Pathology, Uniformed Services University of the Health Sciences, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

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Douglas Van Nostrand Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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Kenneth D Burman Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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Leonard Wartofsky Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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Vasyl Vasko Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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-treatment with WR-1065 (0.1 mM for 1 h) did not prevent H 2 O 2 -induced DNA damage in examined thyroid cancer cell lines, but significantly attenuated H 2 O 2 -inducible DNA damage in NIH3T3 cells. (B) Treatment with H 2 O 2 (0.1 mM) was associated with

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0138
Volume/Issue:
Volume 6: Issue 7
Open access