Huixing Liu
Huixing Liu
Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
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Daoquan Peng
Daoquan Peng
Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
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Introduction Hypothyroidism, including overt and subclinical hypothyroidism is a common disease among people. The former is defined as increased serum thyroid-stimulating hormone (TSH) levels and reduced free peripheral thyroid hormone (TH
Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Min Liu
Min Liu
Department of Radiology, China-Japan Friendship Hospital, Beijing, China
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Zhe Chen
Zhe Chen
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yumei Jia
Yumei Jia
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Introduction Autoimmune thyroiditis (AIT) is the most common autoimmune thyroid disease ( 1 , 2 ). Because of varying degree of thyroid destruction, AIT patients manifest with different thyroid function including euthyroidism, subclinical or
Peter Wolf
Peter Wolf
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Yvonne Winhofer
Yvonne Winhofer
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Martin Krššák
Martin Krššák
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
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High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
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Michael Krebs
Michael Krebs
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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hormone (TSH) <0.1 or ≥10 μU/mL ( 47 ). Especially in patients suffering from congestive heart failure, both subclinical hypothyroidism and overt hypothyroidism are associated with increased mortality ( 48 ). The same is true for patients hospitalized for
Aglaia Kyrilli
Aglaia Kyrilli
Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Bernard Corvilain
Bernard Corvilain
Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Sofie Bliddal
Sofie Bliddal
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Department of Gynecology and Obstetrics, Copenhagen University Hospital (Hvidovre Hospital), Hvidovre, Denmark
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Department of Gynecology and Obstetrics, Copenhagen University Hospital (Hvidovre Hospital), Hvidovre, Denmark
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Dorthe Hansen Precht
Dorthe Hansen Precht
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Carelink Nærhospital, Roskilde, Denmark
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Carelink Nærhospital, Roskilde, Denmark
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Institute of Clinical Medicine, Faculty of Health and Clinical Research, Copenhagen University, Copenhagen, Denmark
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Institute of Clinical Medicine, Faculty of Health and Clinical Research, Copenhagen University, Copenhagen, Denmark
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Kris Poppe
Kris Poppe
Department of Endocrinology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium
Université Libre de Bruxelles (ULB), Brussels, Belgium
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Université Libre de Bruxelles (ULB), Brussels, Belgium
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, depending on the iodine intake in the investigated area and the ethnic background ( 1 , 2 , 3 , 4 , 5 , 6 ). TAI is the strongest predictor for the development of subclinical or overt thyroid dysfunction in the preconception, during pregnancy, and in
Dorte Glintborg
Dorte Glintborg
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Katrine Hass Rubin
Katrine Hass Rubin
OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
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Mads Nybo
Mads Nybo
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
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Bo Abrahamsen
Bo Abrahamsen
OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
Department of Medicine, Holbæk Hospital, Holbæk, Denmark
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Department of Medicine, Holbæk Hospital, Holbæk, Denmark
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Marianne Andersen
Marianne Andersen
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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disease in PCOS. The possible clinical and metabolic side effects of subclinical hypothyroidism in PCOS are currently debated. A recent meta-analysis included TSH data from 577 women with PCOS and subclinical hypothyroidism (elevated TSH and normal
Ulla Schmidt
Ulla Schmidt
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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Birte Nygaard
Birte Nygaard
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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Ebbe Winther Jensen
Ebbe Winther Jensen
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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Jan Kvetny
Jan Kvetny
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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Anne Jarløv
Anne Jarløv
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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Jens Faber
Jens Faber
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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Endocrine Unit, Department of Medicine, Endocrine Unit, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, Herlev Ringvej, DK-2730 Herlev, Denmark
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-known enhanced bone turnover in subclinical hyperthyroidism, both exogenous (due to T 4 treatment) and endogenous (21) . However, no difference was found in the PINP levels of patients on T 4 vs T 3 monotherapy (12) . It is not clear whether our findings are
Mírian Romitti
Mírian Romitti
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Vitor C Fabris
Vitor C Fabris
Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Patricia K Ziegelmann
Patricia K Ziegelmann
Postgraduate Program in Epidemiology and Department of Statistics, Institute of Mathematics, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Ana Luiza Maia
Ana Luiza Maia
Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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Poli Mara Spritzer
Poli Mara Spritzer
Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, and Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
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years without overt thyroid dysfunction. Hence, AITD often goes unnoticed until the onset of hypothyroidism later in life ( 29 ). Furthermore, a recent meta-analysis has demonstrated that the presence of subclinical hypothyroidism in PCOS women produces
Xiujuan Su
Xiujuan Su
Department of Women & Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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Yan Zhao
Yan Zhao
Department of Women & Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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Zhijuan Cao
Zhijuan Cao
Department of Women & Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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Yingying Yang
Yingying Yang
Department of Women & Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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Tony Duan
Tony Duan
Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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Jing Hua
Jing Hua
Department of Women & Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
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controversial results on the effect of subclinical hypothyroidism or hyperthyroidism on health, a randomised controlled trial showed that treatment of subclinical hypothyroidism appears beneficial for women who were undergoing in vitro fertilisation ( 11
Fidéline Bonnet-Serrano
Fidéline Bonnet-Serrano
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
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Maxime Barat
Maxime Barat
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Radiology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Radiology Department, Cochin Hospital, Paris, France
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Anna Vaczlavik
Anna Vaczlavik
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Anne Jouinot
Anne Jouinot
Inserm U1016-CNRS UMR8104, Paris, France
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Lucas Bouys
Lucas Bouys
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Christelle Laguillier-Morizot
Christelle Laguillier-Morizot
Université Paris Cité, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Corinne Zientek
Corinne Zientek
Hormonology Department, Cochin Hospital, Paris, France
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Catherine Simonneau
Catherine Simonneau
Hormonology Department, Cochin Hospital, Paris, France
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Etienne Larger
Etienne Larger
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Diabetology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Diabetology Department, Cochin Hospital, Paris, France
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Laurence Guignat
Laurence Guignat
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Lionel Groussin
Lionel Groussin
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Guillaume Assié
Guillaume Assié
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Jean Guibourdenche
Jean Guibourdenche
Université Paris Cité, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Ioannis Nicolis
Ioannis Nicolis
Université Paris Cité, Paris, France
UR 7537 BioSTM, Paris, France
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UR 7537 BioSTM, Paris, France
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Marie-Claude Menet
Marie-Claude Menet
Institut de Chimie Physique, Université Paris-Saclay-CNRS, UMR8000, Orsay, France
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Jérôme Bertherat
Jérôme Bertherat
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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adjustment for multiple comparisons ( 22 ). The same tests were used to compare the three groups of subjects based on cortisol level secretion (normal N, subclinical SC and excessive CS cortisol secretion) and between the three groups of bilateral tumors
Ling Sun
Ling Sun
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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Wenwu Zhu
Wenwu Zhu
Department of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of Nanjing Medical University, Xuzhou, Jiangsu, China
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Yuan Ji
Yuan Ji
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Ailin Zou
Ailin Zou
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Lipeng Mao
Lipeng Mao
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
Dalian Medical University, Dalian, Liaoning, China
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Dalian Medical University, Dalian, Liaoning, China
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Boyu Chi
Boyu Chi
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
Dalian Medical University, Dalian, Liaoning, China
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Dalian Medical University, Dalian, Liaoning, China
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Jianguang Jiang
Jianguang Jiang
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Xuejun Zhou
Xuejun Zhou
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Qingjie Wang
Qingjie Wang
Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China
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Fengxiang Zhang
Fengxiang Zhang
Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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elevated FT3 and (or) FT4 levels with reduced serum TSH level; hypothyroidism as decreased FT3 and (or) FT4 levels with increased TSH level; subclinical hyperthyroidism as decreased serum TSH level and normal serum FT4 and FT3 levels ( 22 ); and subclinical
