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Jan-Bernd Stukenborg, Kirsi Jahnukainen, Marsida Hutka and Rod T Mitchell

involved in maintenance of the germ-stem cell niche and highlighted their impacts on fertility when these pathways are disrupted (reviewed in ( 2 , 3 )). In humans, cancer and its treatment are a recognised cause of subsequent infertility. This may be as

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Nicola Tufton, Lucy Shapiro, Anju Sahdev, Ajith V Kumar, Lee Martin, William M Drake, Scott A Akker and Helen L Storr

regular surveillance imaging, there is no clear consensus regarding the optimal modality or frequency. The situation is even less clear in paediatric SDHB carriers due to the paucity of robust data, highlighted in a recent review ( 9 ). Since the

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Jaafar Jaafar, Eugenio Fernandez, Heba Alwan and Jacques Philippe

care givers and specialists. Other than endocrinologists, primary care doctors and other specialists, such as pneumologists, gastroenterologists, dermatologists, hematologists and neurologists, are concerned by these irAEs. This review addresses the

Open access

Ruth Therese Casey, Deborah Saunders, Benjamin George Challis, Deborah Pitfield, Heok Cheow, Ashley Shaw and Helen Lisa Simpson

magnitude of exposure. Methods We performed a retrospective review of medical records of 54 patients attending our institution with a confirmed clinical or genetic diagnosis of MEN1 between the years 2007 and 2015. We obtained clinical and

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Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani and John Nestler

been evaluated in randomized controlled trials (RCTs). A protocol critically reviewing the existing literature has been published within the Cochrane Reviews ( 36 ). The present meta-analysis would identify RCTs of supplementation with MI alone or

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André Marques-Pinto and Davide Carvalho

gamete production through to intrauterine development of the offspring – is believed to be particularly susceptible to endocrine disruption, triggering morphological and functional abnormalities (25, 26, 27) . The main purpose of this paper is to review

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Aldo Bonaventura, Fabrizio Montecucco and Franco Dallegri

and compliance with achieving good glycemic control that minimizes the risk of diabetic complications, with a consequent increase in cardiovascular (CV) and neurological morbidities. In this review, based on the material searched for and obtained via

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A Al-Sharefi, P Perros and R A James

-threatening cardiovascular complications due to phaeochromocytoma crises triggered by tumour manipulation, anaesthesia, drugs, pregnancy ( 8 ) or rarely, metastatic disease. Given the uncertainty regarding the value of screening, we reviewed the literature for evidence of

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Joana Simões-Pereira, Daniel Macedo and Maria João Bugalho

analysis. Finally, clinical records were reviewed to evaluate the demographic characteristics, clinical presentation, diagnostic approach, therapeutic modalities and clinical outcome. The results presented herein resulted from a retrospective study based

Open access

Frederic Schrøder Arendrup, Severine Mazaud-Guittot, Bernard Jégou and David Møbjerg Kristensen

the bile and later intestines ( 7 ). Several experimental and epidemiological studies have in recent years investigated a possible link between prenatal mild analgesics exposure and effects on the male reproductive system (reviewed in 2 ). Studies