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Anne H van der Spek Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Olga V Surovtseva Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Saskia Aan Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Anton T J Tool Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Annemarie van de Geer Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Korcan Demir Division of Pediatric Endocrinology, Dokuz Eylül University, Izmir, Turkey

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Anja L M van Gucht Department of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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A S Paul van Trotsenburg Department of Pediatric Endocrinology, Academic Medical Center, Amsterdam, The Netherlands

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Timo K van den Berg Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Anita Boelen Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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. Interestingly, elevated circulating IL-8 levels have also been described in hyperthyroidism (both Graves’ disease and toxic multinodular goiter) ( 45 ). Furthermore, T 3 induces IL-8 production in bone marrow stromal cells and a human osteoblast cell line ( 46

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0213
Volume/Issue:
Volume 6: Issue 8
Open access
Muthiah Subramanian Department of General Medicine, TB and Pulmonary Medicine, Endocrinology, Sri Ramachandra University, 1 Ramachandra Nagar, Porur, Chennai 600116, India

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Manu Kurian Baby Department of General Medicine, TB and Pulmonary Medicine, Endocrinology, Sri Ramachandra University, 1 Ramachandra Nagar, Porur, Chennai 600116, India

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Krishna G Seshadri Department of General Medicine, TB and Pulmonary Medicine, Endocrinology, Sri Ramachandra University, 1 Ramachandra Nagar, Porur, Chennai 600116, India

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Introduction Although antithyroid drugs (ATDs) and partial thyroidectomy have established the treatment modalities, radioiodine therapy has become the primary treatment option of hyperthyroidism in Graves' disease (1, 2) . A number of interrelated

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0119
Volume/Issue:
Volume 5: Issue 1
Open access
Adriano N Cury Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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Verônica T Meira Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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Osmar Monte Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil
Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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Marília Marone Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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Nilza M Scalissi Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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Cristiane Kochi Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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Luís E P Calliari Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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Carlos A Longui Pediatric Endocrinology Unit, Endocrinology and Metabolism, Nuclear Medicine Laboratory, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, 01221-020 São Paulo, Brazil

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clinical features and laboratory findings of hyperthyroidism due to GD. At the time that RAI was administered, the patients' ages ranged from 5 to 19 years. The variables that we studied included associated diseases, gender, age, and stage of puberty

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0049
Volume/Issue:
Volume 2: Issue 1
Open access
Lian Duan Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China

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Han-Yu Zhang Changzhi Medical College, Changzhi, Shanxi, China

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Min Lv Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China

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Han Zhang Changzhi Medical College, Changzhi, Shanxi, China

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Yao Chen Changzhi Medical College, Changzhi, Shanxi, China

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Ting Wang Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China

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Yan Li Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China

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Yan Wu Department of Clinical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China

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Junfeng Li Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China

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Kefeng Li School of Medicine, University of California, San Diego, California, USA

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Introduction Graves’ disease (GD) is an autoimmune disease with the overproduction of thyroid-stimulating hormones (TSH) induced by the activation of thyrotropin-receptor antibodies (TRAb) ( 1 ). It is the most common cause of hyperthyroidism

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0119
Volume/Issue:
Volume 11: Issue 5
Open access
Eng-Loon Tng Department of Medicine, Level 8, Tower A, Ng Teng Fong General Hospital, Singapore

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Yee Sian Tiong Department of Medicine, Level 8, Tower A, Ng Teng Fong General Hospital, Singapore

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Aye Thida Aung Department of Medicine, Level 8, Tower A, Ng Teng Fong General Hospital, Singapore

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Nicole Ya Yuan Chong Department of Medicine, National University Hospital, Singapore

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Zhemin Wang Department of Medicine, National University Hospital, Singapore

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Introduction Atrial fibrillation (AF) occurs in 6–28% of people with hyperthyroidism ( 1 , 2 , 3 , 4 , 5 , 6 ). Thyrotoxicosis increases the activities of thrombin, fibrinogen, factor VIII, factor IX, von Willebrand factor, and tissue

Article Type:
Research Article
Collections:
Cardiovascular
DOI:
https://doi.org/10.1530/EC-22-0166
Volume/Issue:
Volume 11: Issue 5
Open access
Chun-feng Lu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Wang-shu Liu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Xiao-qin Ge Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Feng Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Jian-bin Su Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Xue-qin Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Yan Wang Department of Geriatrics, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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in the treatment of hyperthyroidism partly by inhibiting the activity of ADA, so ADA might be a potential therapeutic target for GD. However, to our knowledge, there are no clinical studies that have explored the relationship between serum ADA levels

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0344
Volume/Issue:
Volume 10: Issue 10
Open access
Sarah Christine Sentis Institute for Endocrinology and Diabetes, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

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Rebecca Oelkrug Institute for Endocrinology and Diabetes, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

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Jens Mittag Institute for Endocrinology and Diabetes, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

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hormone levels. During mild hypo- or hyperthyroidism, brown fat thermogenesis is adjusted to compensate for the change in obligatory thermogenesis and/or heat loss. In strong hypothyroidism, brown fat function fails entirely. In strong hyperthyroidism, the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0562
Volume/Issue:
Volume 10: Issue 2
Open access
Elena Izkhakov Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel

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Joseph Meyerovitch Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Community Division, Clalit Health Services, Tel Aviv, Israel
The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children’s Medical Center of Israel, Petah Tikva, Israel

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Micha Barchana School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel

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Yacov Shacham Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

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Naftali Stern Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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Lital Keinan-Boker School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
National Cancer Registry, Israel Center for Disease Control, Ministry of Health, Israel, Ramat Gan, Israel

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retrospective cohort study did reveal increased cerebrovascular events in both hyperthyroid and euthyroid patients treated with radioiodine for benign thyroid disorders ( 21 ). This supports the possible contribution of radioiodine treatment to cerebrovascular

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0038
Volume/Issue:
Volume 8: Issue 4
Open access
Selma Flora Nordqvist Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Victor Brun Boesen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Åse Krogh Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Per Karkov Cramon Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark

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Torquil Watt Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Department of Internal Medicine, Herlev Gentofte Hospital, Copenhagen, Denmark

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Mogens Groenvold Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark

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Jakob Bue Bjorner Department of Public Health, University of Copenhagen, Copenhagen, Denmark
National Research Centre for the Working Environment, Copenhagen, Denmark
QualityMetric Incorporated, LLC, Johnston, Rhode Island, USA

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) measures The ThyPRO measures a range of aspects of QoL relevant to patients with benign thyroid disease. It covers not only physical symptoms specifically relevant to thyroid diseases, for example, symptoms of hyperthyroidism and goiter, but also

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0026
Volume/Issue:
Volume 10: Issue 3
Open access
Mengxue Yang Department of Endocrinology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China
Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Bowen Sun Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Jianhui Li Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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Bo Yang Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Jie Xu School of Public Health, Zunyi Medical University, Zunyi, China

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Xue Zhou Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Jie Yu School of Public Health, Zunyi Medical University, Zunyi, China

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Xuan Zhang Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Qun Zhang Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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Shan Zhou Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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Xiaohua Sun Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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Introduction Graves’ disease (GD) is an organ-specific autoimmune thyroid disease (AITD) ( 1 , 2 ) and the most common cause of hyperthyroidism in iodine-sufficient geographical areas ( 3 ). According to the literature, the prevalence of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0001
Volume/Issue:
Volume 8: Issue 7
Open access