Lizhi Zhang
Lizhi Zhang
Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Jinwei He
Jinwei He
Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Xiang Sun
Xiang Sun
Shanghai Institute of Technology, Shanghai, China
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Dongyue Pang
Dongyue Pang
Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
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Jingjing Hu
Jingjing Hu
Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
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Bo Feng
Bo Feng
Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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884 postmenopausal women was 47.41 years, and 90% of them had osteopenia/osteoporosis and 307 women had a history of fractures. These 307 women were ruled out of diseases and external factors that affect bone metabolism, accounting for approximately 34
Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Weili Yin
Weili Yin
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Qiuxia Lin
Qiuxia Lin
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yuanna Ling
Yuanna Ling
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Zhen Li
Zhen Li
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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soft tissue components; (ii) new SREs (pathological fractures, cord compression, surgery, or EBRT) ( 13 ); (iii) Also, when a bone lesion was measurable (with a soft tissue mass ≥10 mm), an increase of at least 20% (with at least a 5-mm increase) in the
Francesca Marini
Francesca Marini
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
F.I.R.M.O. Italian Foundation for the Research on Bone Diseases, Florence, Italy
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F.I.R.M.O. Italian Foundation for the Research on Bone Diseases, Florence, Italy
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Francesca Giusti
Francesca Giusti
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
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Teresa Iantomasi
Teresa Iantomasi
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
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Federica Cioppi
Federica Cioppi
University Hospital of Florence, Azienda Ospedaliero Universitaria Careggi (AOUC), Florence, Italy
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Maria Luisa Brandi
Maria Luisa Brandi
F.I.R.M.O. Italian Foundation for the Research on Bone Diseases, Florence, Italy
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alteration of the degree of osteoclast–osteoblast coupling, resulting in bone mineral density (BMD) loss ( 9 ). ACTH-secreting adenomas cause Cushing syndrome, of which osteoporosis and increased risk of fragility fracture are well-recognized complications
Stefan Pilz
Stefan Pilz
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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Armin Zittermann
Armin Zittermann
Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr University Bochum, Bad Oeynhausen, Germany
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Christian Trummer
Christian Trummer
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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Verena Theiler-Schwetz
Verena Theiler-Schwetz
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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Elisabeth Lerchbaum
Elisabeth Lerchbaum
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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Martin H Keppel
Martin H Keppel
University Institute for Medical and Chemical Laboratory Diagnostics, Paracelsus Medical University, Salzburg, Austria
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Martin R Grübler
Martin R Grübler
Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University Hospital, University of Bern, Bern, Switzerland
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Winfried März
Winfried März
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Ruperto-Carola University of Heidelberg, Heidelberg, Germany
Synlab Medical Center of Human Genetics Mannheim, Mannheim, Germany
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Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Ruperto-Carola University of Heidelberg, Heidelberg, Germany
Synlab Medical Center of Human Genetics Mannheim, Mannheim, Germany
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Marlene Pandis
Marlene Pandis
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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supplementation on falls and fractures, the current meta-analyses of RCTs draw inconsistent conclusions with either a neutral or a small beneficial effect ( 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ). Beyond methodological issues of
Kaisu Luiro
Kaisu Luiro
Department of Obstetrics and Gynecology, Reproductive Medicine Unit, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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Kristiina Aittomäki
Kristiina Aittomäki
Department of Medical Genetics, Helsinki University Hospital, Helsinki, Finland
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Pekka Jousilahti
Pekka Jousilahti
Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
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Juha S Tapanainen
Juha S Tapanainen
Department of Obstetrics and Gynecology, Reproductive Medicine Unit, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit, Oulu, Finland
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Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit, Oulu, Finland
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due to CVD, osteoporosis and fractures. In addition, impairment of cognitive functions, dementia, Parkinsonism, and reduced sexual function and psychological well-being have been reported ( 12 ). Most of the evidence comes from observational studies of
Georgios Kontogeorgos
Georgios Kontogeorgos
Section for Geriatrics and Emergency Medicine, Department of Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Zoi Mamasoula
Zoi Mamasoula
Section for Geriatrics and Emergency Medicine, Department of Medicine, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Emily Krantz
Emily Krantz
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Penelope Trimpou
Penelope Trimpou
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Kerstin Landin-Wilhelmsen
Kerstin Landin-Wilhelmsen
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Section for Endocrinology, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Christine M Laine
Christine M Laine
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Endocrine Out-Patient Clinic, Carlanderska Hospital, Gothenburg, Sweden
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Endocrine Out-Patient Clinic, Carlanderska Hospital, Gothenburg, Sweden
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doses, laboratory analyses, blood pressure, and the occurrence of other comorbidities and complications, such as renal failure and soft tissue calcifications, as well as fracture history were recorded. Patients were divided into two different groups
Henrik Falhammar
Henrik Falhammar
Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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Hedi Claahsen-van der Grinten
Hedi Claahsen-van der Grinten
Department of Pediatric Endocrine Disease, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Nicole Reisch
Nicole Reisch
Medizinische Klinik and Poliklinik IV, Department of Endocrinology, University Hospital Munich, Munich, Germany
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Jolanta Slowikowska-Hilczer
Jolanta Slowikowska-Hilczer
Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, Lodz, Poland
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Anna Nordenström
Anna Nordenström
Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden
Department of Paediatric Endocrinology, Astrid Lindgren Children Hospital, Karolinska University Hospital, Stockholm, Sweden
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Department of Paediatric Endocrinology, Astrid Lindgren Children Hospital, Karolinska University Hospital, Stockholm, Sweden
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Robert Roehle
Robert Roehle
Coordinating Center for Clinical Studies, Charité Universitätsmedizin, Berlin, Germany
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Claire Bouvattier
Claire Bouvattier
Paris-Sud University, Orsay, France
Department of Pediatric Endocrinology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France
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Department of Pediatric Endocrinology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, France
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Baudewijntje P C Kreukels
Baudewijntje P C Kreukels
Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands
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Birgit Köhler
Birgit Köhler
Department of Paediatric Endocrinology and Diabetology, Charité Universitätsmedizin, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
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on behalf of the dsd-LIFE group
on behalf of the dsd-LIFE group
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disorders in addition to decreased bone health with increased fracture incidence for all groups ( 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ). A healthy lifestyle can modify and prevent many of these
K Amrein
K Amrein
Thyroid Endocrinology Osteoporosis Institute Dobnig, Graz, Austria
Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
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A Papinutti
A Papinutti
Department of General Surgery, Medical University of Graz, Graz, Austria
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E Mathew
E Mathew
Department of General Surgery, Medical University of Graz, Graz, Austria
Department of General Surgery, St. Elisabeth’s Hospital, Graz, Austria
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Department of General Surgery, St. Elisabeth’s Hospital, Graz, Austria
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G Vila
G Vila
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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D Parekh
D Parekh
Clinician Scientist in Critical Care, Birmingham, Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
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) Bone Limited available data in ICU survivors suggest impaired bone health and high fracture risk ( 38 , 39 , 40 , 41 , 83 ). 1,25(OH)(2)D(3) is known primarily as a regulator of calcium, but it also controls phosphate (re)absorption at the
Maria Mizamtsidi
Maria Mizamtsidi
Department of Endocrinology, Diabetes and Metabolism, Hellenic Red Cross Hospital, Athens, Greece
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Constantinos Nastos
Constantinos Nastos
Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece
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George Mastorakos
George Mastorakos
Unit of Endocrinology, Diabetes and Metabolism, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece
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Roberto Dina
Roberto Dina
Department of Pathology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK
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Ioannis Vassiliou
Ioannis Vassiliou
Second Department of Surgery, Endocrine Surgery Unit, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece
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Maria Gazouli
Maria Gazouli
Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Fausto Palazzo
Fausto Palazzo
Department of Thyroid and Endocrine Surgery, Imperial College London, London, UK
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/3 radius or low-energy fracture, glomerular filtration rate (GFR) of <60 mL/min, nephrocalcinosis, renal stones or high stone risk). Table 1 presents the latest guidelines in comparison with older ones for the management of asymptomatic pHPT. Data from
Zhiyan Yu
Zhiyan Yu
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Yueyue Wu
Yueyue Wu
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Rui Zhang
Rui Zhang
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Yue Li
Yue Li
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Shufei Zang
Shufei Zang
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Jun Liu
Jun Liu
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Introduction Osteoporosis is a systemic bone disease characterized by decrease in bone mass and damage to the microstructure of bone tissue, resulting in increased bone fragility and susceptibility to fracture ( 1 ). Pain due to osteoporosis
