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depot, while perirenal fat mainly consists of dormant brown adipose tissue ( 16 ). However, perirenal fat is more active in energy metabolism and adipokine secretion compared with typical visceral fat ( 12 ). It has been proved that massive perirenal fat
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respectively located in the ER and outer membrane, and their downregulation could affect calcium ion transfer and energy metabolism between mitochondria and the ER ( 20 , 21 , 22 ). Drp1 is a protein involved in mitochondrial fission and its downregulation
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mass, including energy metabolism, appetite control, and adipogenesis, leading to a thrifty phenotype and increasing the susceptibility to weight gain. The obesogenic effect of early-life exposure to EDCs is supported by many animal and
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mitochondrial fusion, as a mutant form of mitofusin 2, lacking the ability to induce fusion, was still able to stimulate energy metabolism (104) . Decreased oxygen consumption and mitochondrial dysfunction were also observed in vivo in mice with simultaneous
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‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
‘Research of Age and Age-Associated Conditions’ Department, Laboratory of Bioinformatics, The ‘Russian Clinical Research Center for Gerontology’, ‘Chronic Noncommunicable Diseases Primary Prevention in the Healthcare System’ Department, Moscow Institute of Physics and Technology, National Research Centre for Preventive Medicine, National Research Centre for Preventive Medicine, Building 10, Petroverigskiy Lane, Moscow RF 101000, Russian Federation
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the microbiota, as well as its relationship with the macroorganism, is constantly expanding. Although the GM role in the energy metabolism regulation is not completely clear and the literature data are contradictory, there are grounds to assume that
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