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Line Tang Møllehave Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark

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Marie Holm Eliasen Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark

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Ieva Strēle The Institute of Occupational Safety and Environmental Health, Riga Stradiņš University, Riga, Latvia

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Allan Linneberg Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Rodrigo Moreno-Reyes Nuclear Medicine Department, Erasme Hospital, Brussels, Belgium
Université Libre de Bruxelles, Bruxelles, Belgium

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Ludmila B Ivanova Faculty of Medicine, Sofia University St. Kl. Ohridski, Sofia, Bulgaria

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Zvonko Kusić Croatian Academy of Sciences and Arts, Zagreb, Croatia
School of Medicine, Zagreb, Croatia

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Iris Erlund Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland

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Till Ittermann Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Endre V Nagy Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

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Ingibjorg Gunnarsdottir Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland
Department of Clinical Nutrition, Landspitali-National University Hospital, Reykjavik, Iceland

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Jonathan Eli Arbelle Division of Medicine, Maccabi Healthcare Services, Tel Aviv, Israel
Goldman School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel

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Aaron Milton Troen The Institute of Biochemistry Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, Israel

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Valdis Pīrāgs Internal Medicine, University of Latvia, Riga, Latvia

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Lisbeth Dahl Seafood, Nutrition and Environmental State, Institute of Marine Research (IMR), Bergen, Norway

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Alicja Hubalewska-Dydejczyk Chair and Department of Endocrinology, Jagiellonian University, Medical College, Cracow, Poland

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Malgorzata Trofimiuk-Müldner Chair and Department of Endocrinology, Jagiellonian University, Medical College, Cracow, Poland

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João Jacome de Castro Endocrine Department, Armed Forces Hospital, Lisbon, Portugal

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Mafalda Marcelino Endocrine Department, Armed Forces Hospital, Lisbon, Portugal

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Simona Gaberšček Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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Katja Zaltel Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

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Manuel Puig-Domingo Department of Endocrinology and Nutrition, Germans Trias Research Institute and Hospital, Badalona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain

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Lluis Vila Endocrinology and Nutrition Service, Hospital Moisés Broggi, Sant Juan Despi, Barcelona, Spain

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Sofia Manousou Sahlgrenska Academy, Institute of Medicine, Gothenburg, Sweden
Frölunda Specialist Hospital, Västra Frölunda, Sweden

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Helena Filipsson Nyström Department of Endocrinology, Specialist Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg Centre of Molecular and Translational Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Michael Bruce Zimmermann Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

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Karen R Mullan Regional Centre for Endocrinology and Diabetes, Belfast Health and Social Care Trust, Belfast, UK

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Jayne Valerie Woodside Centre for Public Health, Queen’s University Belfast, Belfast, UK

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Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Betina Heinsbæk Thuesen Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark

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cross-sectional survey in Belgium . Thyroid 2012 22 1046 – 1053 . ( https://doi.org/10.1089/thy.2012.0016 ) 16 Latvijas Vēstnesis. Regulation No. 696: regulations regarding edible salt . Riga, Latvia : Latvijas Vēstnesis , 2015 . 17 Global

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Estíbaliz Castillero
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Ana Isabel Martín
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Maria Paz Nieto-Bona Department of Physiology, Department of Histology, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain

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Carmen Fernández-Galaz
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María López-Menduiña
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María Ángeles Villanúa
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Asunción López-Calderón
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were used to determine the whole cross-sectional area. Sections were scanned (Epson scanner 4990) with a transparent rule and the area was measured using Image J software (Bethesda, MD, USA). Muscle fiber cross-sectional size was as an index of fiber

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Iben Katinka Greiber Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Casper P Hagen Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Alexander Siegfried Busch Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Mikkel Grunnet Mieritz Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Lise Aksglæde Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Katharina Main Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Kristian Almstrup Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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), a population-based combined cross-sectional and longitudinal cohort study of healthy Danish children and adolescents. The study was conducted at ten schools in the Copenhagen area, 2006–2014. All pupils were invited, 3102 girls and 3101 boys of whom

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Yinqiong Huang Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

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Zhaozhao Zhu Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China

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Zhiqin Huang Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

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Jingxiong Zhou Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

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glomerular filtration rate, indicating that TMAO might be a biomarker of renal function or as a risk factor for macro- and microvascular complications, especially impaired renal function. Another cross-sectional survey study showed that elevated plasma TMAO

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Huda M Elsharkasi Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK

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Suet C Chen Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK

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Lewis Steell Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK

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Shuko Joseph Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK
Paediatric Neurosciences Research Group, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK

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Naiemh Abdalrahaman Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK

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Christie McComb Department of Clinical Physics, NHS Greater Glasgow & Clyde, Glasgow, UK

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Blair Johnston Department of Clinical Physics, NHS Greater Glasgow & Clyde, Glasgow, UK

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John Foster Department of Clinical Physics, NHS Greater Glasgow & Clyde, Glasgow, UK

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Sze Choong Wong Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK

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S Faisal Ahmed Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK

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readout was used with a total scan time = 3.00 min. The images were then analysed to obtain measurements of muscle fat fraction as a percentage (MFF%), total muscle cross-sectional area (muscle CSA, mm 2 ) and residual muscle area (i.e. muscle tissue after

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Valeria Hirschler University of Buenos Aires, Buenos Aires, Argentina

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Claudia Molinari University of Buenos Aires, Buenos Aires, Argentina

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Silvia Lapertosa UNNE, Corrientes, Argentina

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Gustavo Maccallini Hidalgo Laboratories, Buenos Aires, Argentina

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Claudio D Gonzalez CEMIC, Buenos Aires, Argentina

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, Buenos Aires suburbs, Argentina. Methods This cross-sectional study was performed in Buenos Aires suburbs, Argentina, between November 2013 and 2015. The study was approved by the Human Rights Committee of the University of Buenos Aires. Each

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T L C Wolters Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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C D C C van der Heijden Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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N van Leeuwen Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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B T P Hijmans-Kersten Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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M G Netea Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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J W A Smit Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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D H J Thijssen Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK

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A R M M Hermus Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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N P Riksen Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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R T Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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and healthy controls. By including both patients with active disease under treatment and controlled disease, we aimed to elucidate whether these properties are reversible after disease control. Materials and methods This cross-sectional case

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Angela Köninger
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Philippos Edimiris
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Laura Koch
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Antje Enekwe
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Claudia Lamina Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany

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Sabine Kasimir-Bauer
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Rainer Kimmig
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Hans Dieplinger Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany

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. Of them, 85 patients suffered from PCOS, and the remaining 76 PCOS-free patients served as controls in a cross-sectional study design. All patients were treated at the University Hospital of Essen, Department of Obstetrics and Gynecology, between 2009

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Xiaoxia Jia Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Yaxin An Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Yuechao Xu Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Yuxian Yang Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Chang Liu Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Dong Zhao Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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Jing Ke Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China

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limitations in our study as well. First, as our study is cross-sectionally designed, it could not establish a causal relationship between PrFT and β-CTX. Further studies are needed to illuminate the specific mechanism. Last, we measured PrFT and PnFT by

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Franca Genest Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany

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Michael Schneider Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany

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Andreas Zehnder Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany

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Dominik Lieberoth-Leden Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany

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Lothar Seefried Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany

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supposed ‘osteosarcobesity’ or ‘sarcoporobestiy’ was a realistic worst-case scenario. Materials and methods Study design and participants This is a cross-sectional evaluation of a general population-derived cohort of elderly men. Based on

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