Eeva M Ryhänen
Eeva M Ryhänen
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Ilkka Heiskanen
Ilkka Heiskanen
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Harri Sintonen
Harri Sintonen
Endocrinology, Department of Public Health, Group Administration, Helsinki University Hospital, University of Eastern Finland, Abdominal Center, University of Helsinki and Helsinki University Hospital, Post Box 340, FI-00290 Helsinki, Finland
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Matti J Välimäki
Matti J Välimäki
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Risto P Roine
Risto P Roine
Endocrinology, Department of Public Health, Group Administration, Helsinki University Hospital, University of Eastern Finland, Abdominal Center, University of Helsinki and Helsinki University Hospital, Post Box 340, FI-00290 Helsinki, Finland
Endocrinology, Department of Public Health, Group Administration, Helsinki University Hospital, University of Eastern Finland, Abdominal Center, University of Helsinki and Helsinki University Hospital, Post Box 340, FI-00290 Helsinki, Finland
Endocrinology, Department of Public Health, Group Administration, Helsinki University Hospital, University of Eastern Finland, Abdominal Center, University of Helsinki and Helsinki University Hospital, Post Box 340, FI-00290 Helsinki, Finland
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Endocrinology, Department of Public Health, Group Administration, Helsinki University Hospital, University of Eastern Finland, Abdominal Center, University of Helsinki and Helsinki University Hospital, Post Box 340, FI-00290 Helsinki, Finland
Endocrinology, Department of Public Health, Group Administration, Helsinki University Hospital, University of Eastern Finland, Abdominal Center, University of Helsinki and Helsinki University Hospital, Post Box 340, FI-00290 Helsinki, Finland
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Camilla Schalin-Jäntti
Camilla Schalin-Jäntti
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cure of PHPT. There is consensus that patients with markedly increased serum calcium concentrations or signs of skeletal or nephrological complications should undergo parathyroidectomy (4) . Neuropsychological symptoms and impaired quality of life are
Lasse Oinonen
Lasse Oinonen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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Antti Tikkakoski
Antti Tikkakoski
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Jenni Koskela
Jenni Koskela
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Arttu Eräranta
Arttu Eräranta
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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Mika Kähönen
Mika Kähönen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Onni Niemelä
Onni Niemelä
Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital, Seinäjoki, Finland
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Jukka Mustonen
Jukka Mustonen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Ilkka Pörsti
Ilkka Pörsti
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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enhanced reactivity to the pressor factors of the sympathetic nervous system and the renin-angiotensin-aldosterone axis ( 16 , 20 , 21 ), may contribute to the elevation of BP in hyperparathyroidism. We recently found that plasma total calcium
Budoor Alemadi
Budoor Alemadi
Endocrinology Department, Dubai Hospital, Dubai Health, Dubai, UAE
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Fauzia Rashid
Fauzia Rashid
Endocrinology Department, Dubai Hospital, Dubai Health, Dubai, UAE
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Ali Alzahrani
Ali Alzahrani
King Faisal Specialist Hospital & Research Centre, Department of Medicine, Riyadh, Saudi Arabia
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detection of hyperparathyroidism (HPT) has risen considerably in recent decades due to the widespread availability of medical resources and routine testing of calcium levels. However, vague symptoms may delay identification, diagnosis, and timely management
Sara Lomelino Pinheiro
Sara Lomelino Pinheiro
Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Ana Saramago
Ana Saramago
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Branca Maria Cavaco
Branca Maria Cavaco
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Carmo Martins
Carmo Martins
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Valeriano Leite
Valeriano Leite
Serviço de Endocrinologia e Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Tiago Nunes da Silva
Tiago Nunes da Silva
Serviço de Endocrinologia e Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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) Calcium (mmol/L) PTH (pg/mL) MEN1 mutation 1 Wu et al. ( 8 ) 1992 Male 48 4.1 154 – 2 Sato et al. ( 9 ) 2000 Female 51 2.7 – c.734del p.(Pro245Leufs*36) 3 Dionisi et al. ( 10 ) 2002 Male
Johanna Öberg
Johanna Öberg
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
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Rolf Jorde
Rolf Jorde
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
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Yngve Figenschau
Yngve Figenschau
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway
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Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway
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Per Medbøe Thorsby
Per Medbøe Thorsby
Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway
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Sandra Rinne Dahl
Sandra Rinne Dahl
Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway
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Anne Winther
Anne Winther
Division of Neurosciences, Orthopedics and Rehabilitation Services, University Hospital of North Norway, Tromso, Norway
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Guri Grimnes
Guri Grimnes
Tromso Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway
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Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway
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immunoassay at OLINK® Proteomics, Uppsala, Sweden, and reported in Normalized Protein eXpression (NPX) values (log2 scale). Serum PTH, calcium and albumin were analyzed at the Department of Laboratory Medicine, University Hospital of North Norway, Tromsø
Charissa van Zwol-Janssens
Charissa van Zwol-Janssens
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Aglaia Hage
Aglaia Hage
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Kim van der Ham
Kim van der Ham
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Birgitta K Velthuis
Birgitta K Velthuis
Department of Radiology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands
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Ricardo P J Budde
Ricardo P J Budde
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
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Maria P H Koster
Maria P H Koster
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Arie Franx
Arie Franx
Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Bart C J M Fauser
Bart C J M Fauser
Department of Reproductive Medicine and Gynaecology, University Medical Center Utrecht & University of Utrecht, Utrecht, the Netherlands
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Eric Boersma
Eric Boersma
Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Daniel Bos
Daniel Bos
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Joop S E Laven
Joop S E Laven
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands
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Yvonne V Louwers
Yvonne V Louwers
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands
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the CREW consortium
the CREW consortium
the CREW consortium
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-based control group available because non-contrast CCT to measure BD is not the ‘gold standard’. In addition to a previously published study, we showed that CCTs can be used to assess both coronary artery calcium score for cardiovascular screening as well as TBD
Maria Angela D'amico
Maria Angela D'amico
Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy
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Barbara Ghinassi
Barbara Ghinassi
Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy
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Pascal Izzicupo
Pascal Izzicupo
Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy
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Lamberto Manzoli
Lamberto Manzoli
Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy
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A Di Baldassarre
A Di Baldassarre
Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy
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high percentage of acidic amino acids (glutamic acid and aspartic acid), ii) heat stability due to its high hydrophilic nature, iii) the presence of multiple dibasic cleavage sites, and iv) the capacity to form aggregates and to bind calcium
Sharon A Huish
Sharon A Huish
University Hospitals of Coventry and Warwickshire NHS Trust, Coventry, UK
The University of Warwick, Coventry, UK
Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
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The University of Warwick, Coventry, UK
Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
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Carl Jenkinson
Carl Jenkinson
The University of Birmingham, Birmingham, UK
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Janet A Dunn
Janet A Dunn
The University of Warwick, Coventry, UK
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David J Meredith
David J Meredith
Royal Devon and Exeter NHS Foundation Trust, Exeter, UK
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Rosemary Bland
Rosemary Bland
The University of Warwick, Coventry, UK
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Martin Hewison
Martin Hewison
The University of Birmingham, Birmingham, UK
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). Active analogue dose was recorded at baseline and study end. Serum calcium was measured monthly and PTH concentration 3 monthly as part of usual care. Blood samples were taken by renal research nurses at routine dialysis sessions, processed and stored at
Felix Haglund
Felix Haglund
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Gustaf Rosin
Gustaf Rosin
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Inga-Lena Nilsson
Inga-Lena Nilsson
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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C Christofer Juhlin
C Christofer Juhlin
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Ylva Pernow
Ylva Pernow
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Sophie Norenstedt
Sophie Norenstedt
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Andrii Dinets
Andrii Dinets
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Catharina Larsson
Catharina Larsson
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Johan Hartman
Johan Hartman
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Anders Höög
Anders Höög
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology–Pathology, Cancer Centre Karolinska, Department of Biosciences and Nutrition, Department of Molecular Medicine and Surgery, Department of Surgery #4, Karolinska Institutet, Stockholm, Sweden
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according to the WHO criteria. Clinical data are summarised in Table 1 . Table 1 Tumour and clinical characteristics. Tumours 172 Adenomas 161 Atypical adenomas 5 Carcinomas 6 S-calcium (mmol/l) Min 1.31 Mean 1.46 Median 1.43 Max 1.89 Tumour weight
Jeremy Turner
Jeremy Turner
Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
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Neil Gittoes
Neil Gittoes
Centre for Endocrinology, Diabetes and Metabolism, University Hospitals Birmingham & University of Birmingham, Birmingham Health Partners, Birmingham, UK
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Peter Selby
Peter Selby
Department of Medicine, Manchester Royal Infirmary, Manchester, UK
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the Society for Endocrinology Clinical Committee4
the Society for Endocrinology Clinical Committee4
The Society for Endocrinology, Woodlands, Bradley Stoke, Bristol, UK
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In this addendum to the above paper, the Society for Endocrinology Clinical Committee and the original authors provide additional advice on the dose equivalence of calcium gluconate and calcium chloride. The ‘Severe hypocalcaemia’ section
