Stavroula A Paschou
Stavroula A Paschou
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Nektaria Papadopoulou-Marketou
Nektaria Papadopoulou-Marketou
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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George P Chrousos
George P Chrousos
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Christina Kanaka-Gantenbein
Christina Kanaka-Gantenbein
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Huntingtin-interacting protein 14 gene is located on chromosome 12 and encodes for a palmitoyl transferase, which is involved in the metabolism and trafficking of proteins met with neurons. Knockdown of the genes in mice revealed increased apoptosis for
Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Min Liu
Min Liu
Department of Radiology, China-Japan Friendship Hospital, Beijing, China
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Zhe Chen
Zhe Chen
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yumei Jia
Yumei Jia
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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assessing fibrosis of some organs, such as the heart and liver ( 10 , 11 ). Typical thyroid lesions of AIT patients include diffuse lymphocytic infiltration with germinal center formation, fibrosis and apoptosis of thyroid epithelial cells ( 12 ). The
Zeting Li
Zeting Li
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Ling Pei
Ling Pei
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Huangmeng Xiao
Huangmeng Xiao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Nan Chen
Nan Chen
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Fenghua Lai
Fenghua Lai
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Shufang Yue
Shufang Yue
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Changliu Xu
Changliu Xu
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Yanbing Li
Yanbing Li
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Haipeng Xiao
Haipeng Xiao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Xiaopei Cao
Xiaopei Cao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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secreted from pancreatic cells. PANDER has been shown to influence glycolipid metabolism by inducing apoptosis in pancreatic β cells, inhibiting insulin secretion ( 6 , 7 , 8 ), promoting hepatic glucose production, and stimulating lipogenesis ( 9 , 10
Wenrui Wang
Wenrui Wang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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Chuan Zhang
Chuan Zhang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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to β-cell dedifferentiation rather than apoptosis, because the relatively low rate of apoptosis may not fully explain the loss of β-cell mass. β-cell dedifferentiation is characterized by decreased expression of specific genes that maintain the
Davoud Jafari-Gharabaghlou
Davoud Jafari-Gharabaghlou
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Mostafa Vaghari-Tabari
Mostafa Vaghari-Tabari
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Hajar Oghbaei
Hajar Oghbaei
Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
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Laura Lotz
Laura Lotz
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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Reza Zarezadeh
Reza Zarezadeh
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Yeganeh Rastgar Rezaei
Yeganeh Rastgar Rezaei
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Mahnaz Ranjkesh
Mahnaz Ranjkesh
Medical Radiation Science Research Group (MRSRG), Tabriz University of Medical Sciences, Tabriz, Iran
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Mohammad Nouri
Mohammad Nouri
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Amir Fattahi
Amir Fattahi
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Saba Nikanfar
Saba Nikanfar
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Ralf Dittrich
Ralf Dittrich
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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action Ref Leptin Remodeling of the endometrial epithelium (human) Stimulating proliferation and enhancing Fas ligand-induced apoptosis in EECs (39) Repairing endometrial epithelium after embryo implantation (human) ND (39
Wang-shu Liu
Wang-shu Liu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Ling-yan Hua
Ling-yan Hua
Department of Ophthalmology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Su-xiang Zhu
Su-xiang Zhu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Feng Xu
Feng Xu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Xue-qin Wang
Xue-qin Wang
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Chun-feng Lu
Chun-feng Lu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Jian-bin Su
Jian-bin Su
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Feng Qi
Feng Qi
Emergency Intensive Care Unit, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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apoptosis of cardiomyocytes ( 29 ). In addition, SDF-1 can aggravate cardiac remodeling and worsen cardiac function by enhancing the proliferation of cardiac fibroblasts and collagen production ( 30 ). Correspondingly, plasma SDF-1 levels can serve as a
Tingting Shu
Tingting Shu
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Zhigang Lv
Zhigang Lv
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Yuchun Xie
Yuchun Xie
Department of Central Laboratory, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China
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Junming Tang
Junming Tang
Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China
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Xuhua Mao
Xuhua Mao
Department of Clinical Laboratory, Yixing People Hospital, Affiliated Jiangsu University, Yixing, Wuxi, Jiangsu, China
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), ( 19 ) which influences the energy supply required for insulin secretion ( 20 ). Moreover, mitochondrial function becomes impaired, which induces endoplasmic reticulum stress response (ER stress), leading to β-cell apoptosis ( 21 , 22 ). In the
Yusaku Mori
Yusaku Mori
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Eunhyoung Ko
Eunhyoung Ko
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
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Rudolf Furrer
Rudolf Furrer
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
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Linda C Qu
Linda C Qu
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
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Stuart C Wiber
Stuart C Wiber
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
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I George Fantus
I George Fantus
Departments of Medicine and Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Division of Endocrinology and Metabolism, Leadership Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
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Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Division of Endocrinology and Metabolism, Leadership Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
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Mario Thevis
Mario Thevis
Center for Preventive Doping Research and Institute of Biochemistry, German Sport University Cologne, Cologne, Germany
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Alan Medline
Alan Medline
Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
Department of Pathology, Humber River Regional Hospital, Toronto, Ontario, Canada
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Department of Pathology, Humber River Regional Hospital, Toronto, Ontario, Canada
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Adria Giacca
Adria Giacca
Departments of Physiology and Medicine, Institute of Medical Science, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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the mouse model of the ter Braak et al . paper, loss of p53 function by mutation could have prevented the effect of insulin to inhibit apoptosis via PI3K/Akt-mediated suppression of p53 ( 26 , 37 ). Importantly, in the latter study, carcinosarcoma
P G Murray
P G Murray
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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D Hanson
D Hanson
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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T Coulson
T Coulson
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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A Stevens
A Stevens
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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A Whatmore
A Whatmore
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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R L Poole
R L Poole
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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D J Mackay
D J Mackay
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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G C M Black
G C M Black
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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P E Clayton
P E Clayton
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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perinuclear region (5) . The function of CCDC8 is unknown, but it binds to OBSL1 (3) and is required for p53-mediated apoptosis (6) . The mechanisms leading to the growth impairment seen in 3-M syndrome remain unclear, but are likely to relate to
Taís S Assmann
Taís S Assmann
Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Mariana Recamonde-Mendoza
Mariana Recamonde-Mendoza
Institute of Informatics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Bianca M De Souza
Bianca M De Souza
Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Daisy Crispim
Daisy Crispim
Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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regulation of various processes, such as cellular differentiation, proliferation, metabolism, aging and apoptosis ( 10 , 12 ). miRNAs are estimated to regulate the expression of more than 60% of protein-coding genes ( 9 ); consequently, changes in their
