Eric M Ndombi
Eric M Ndombi
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Valentine Budambula
Valentine Budambula
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Mark K Webale
Mark K Webale
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Francis O Musumba
Francis O Musumba
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Jesca O Wesongah
Jesca O Wesongah
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Erick Mibei
Erick Mibei
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Aabid A Ahmed
Aabid A Ahmed
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Raphael Lihana
Raphael Lihana
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Tom Were
Tom Were
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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develop in HIV infected individuals. For instance, accumulation of visceral and dorso-cervical adipose tissue, breast enlargement, and loss of facial and limb subcutaneous fat are attributable to anti-retroviral drugs, especially nucleoside reverse
Stephen A Martin
Stephen A Martin
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Kenneth A Philbrick
Kenneth A Philbrick
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Carmen P Wong
Carmen P Wong
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Dawn A Olson
Dawn A Olson
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Adam J Branscum
Adam J Branscum
Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Donald B Jump
Donald B Jump
Molecular Nutrition and Diabetes Research Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Charles K Marik
Charles K Marik
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Jonathan M DenHerder
Jonathan M DenHerder
Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
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Jennifer L Sargent
Jennifer L Sargent
Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
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Russell T Turner
Russell T Turner
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Urszula T Iwaniec
Urszula T Iwaniec
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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sympathetic outflow from the central nervous system (CNS) to brown adipose tissue (BAT), where heat is generated through the uncoupling of oxidation and phosphorylation by uncoupling proteins (UCPs) ( 9 ). Bone is highly innervated by efferent sympathetic
Sandrine Visentin
Sandrine Visentin
Department of Pediatric Hematology and Oncology, AP-HM, Timone Enfants Hospital, Marseille, France
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
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Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
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Gérard Michel
Gérard Michel
Department of Pediatric Hematology and Oncology, AP-HM, Timone Enfants Hospital, Marseille, France
Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, Marseille, France
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Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, Marseille, France
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Claire Oudin
Claire Oudin
Department of Pediatric Hematology and Oncology, AP-HM, Timone Enfants Hospital, Marseille, France
Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, Marseille, France
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Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, Marseille, France
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Béatrice Cousin
Béatrice Cousin
STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, INSERM U1031, UPS, Toulouse, France
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Bénédicte Gaborit
Bénédicte Gaborit
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
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Inès Abdesselam
Inès Abdesselam
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
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Marie Maraninchi
Marie Maraninchi
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
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Marion Nowicki
Marion Nowicki
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
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René Valéro
René Valéro
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
Nutrition, Metabolic Diseases and Endocrinology Department, AP-HM, La Conception Hospital, Marseille, France
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Nutrition, Metabolic Diseases and Endocrinology Department, AP-HM, La Conception Hospital, Marseille, France
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Maxime Guye
Maxime Guye
AP-HM, Timone, CEMEREM, Marseille, France
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Monique Bernard
Monique Bernard
AP-HM, Timone, CEMEREM, Marseille, France
Aix-Marseille University, CNRS, CRMBM, Marseille, France
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Aix-Marseille University, CNRS, CRMBM, Marseille, France
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Pascal Auquier
Pascal Auquier
Research Unit EA 3279 and Department of Public Health, Aix-Marseille University, Marseille, France
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Hervé Chambost
Hervé Chambost
Department of Pediatric Hematology and Oncology, AP-HM, Timone Enfants Hospital, Marseille, France
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Marie-Christine Alessi
Marie-Christine Alessi
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
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Sophie Béliard
Sophie Béliard
Aix Marseille University, INSERM, INRA, C2VN, Marseille, France
Nutrition, Metabolic Diseases and Endocrinology Department, AP-HM, La Conception Hospital, Marseille, France
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Nutrition, Metabolic Diseases and Endocrinology Department, AP-HM, La Conception Hospital, Marseille, France
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0.12 sSAT (cm 2 , mean ± s.d. ) 265 ± 94 196 ± 96 0.15 106 ± 42 111 ± 62 0.76 178 ± 107 165 ± 92 0.79 AT, adipose tissue; intra-abdominal AT = dSAT+VAT; dSAT, deep SAT; SAT, subcutaneous adipose tissue; sSAT
Sebastião Freitas de Medeiros
Sebastião Freitas de Medeiros
Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Cinthia Marenza Ormond
Cinthia Marenza Ormond
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Matheus Antônio Souto de Medeiros
Matheus Antônio Souto de Medeiros
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Nayara de Souza Santos
Nayara de Souza Santos
Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Camila Regis Banhara
Camila Regis Banhara
Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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Márcia Marly Winck Yamamoto
Márcia Marly Winck Yamamoto
Tropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil
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( 36 ). Furthermore, the adipose tissue product leptin may also inhibit 3β-HSD II activity and increase 17-OHPE levels ( 37 , 38 ). The positive correlation between 17-OHPE and markers of dysglycemia found in the present study is in agreement with the
Yee-Ming M Cheung
Yee-Ming M Cheung
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Australia
Department of Endocrinology, Austin Health, Melbourne, Australia
Division of Endocrinology, Diabetes and Metabolism, Northwell, Great Neck, New York, USA
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Department of Endocrinology, Austin Health, Melbourne, Australia
Division of Endocrinology, Diabetes and Metabolism, Northwell, Great Neck, New York, USA
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Rudolf Hoermann
Rudolf Hoermann
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Australia
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Karen Van
Karen Van
Department of Endocrinology, Austin Health, Melbourne, Australia
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Damian Wu
Damian Wu
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Australia
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Jenny Healy
Jenny Healy
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Australia
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Bella Halim
Bella Halim
Department of Endocrinology, Austin Health, Melbourne, Australia
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Manjri Raval
Manjri Raval
Department of Endocrinology, Austin Health, Melbourne, Australia
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Maria McGill
Maria McGill
Department of Radiology, Austin Health, Melbourne, Australia
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Ali Al-Fiadh
Ali Al-Fiadh
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Australia
Department of Cardiology, Austin Health, Melbourne Australia
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Department of Cardiology, Austin Health, Melbourne Australia
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Michael Chao
Michael Chao
Olivia Newton-John Cancer Research and Wellness Centre, Austin Health, Melbourne, Australia
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Shane White
Shane White
Olivia Newton-John Cancer Research and Wellness Centre, Austin Health, Melbourne, Australia
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Belinda Yeo
Belinda Yeo
Olivia Newton-John Cancer Research and Wellness Centre, Austin Health, Melbourne, Australia
Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
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Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia
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Jeffrey D Zajac
Jeffrey D Zajac
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Australia
Department of Endocrinology, Austin Health, Melbourne, Australia
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Department of Endocrinology, Austin Health, Melbourne, Australia
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Mathis Grossmann
Mathis Grossmann
Department of Medicine, The University of Melbourne, Austin Health, Melbourne, Australia
Department of Endocrinology, Austin Health, Melbourne, Australia
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Department of Endocrinology, Austin Health, Melbourne, Australia
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oestrogen states ( 18 , 19 ) have been associated with increases in visceral adipose tissue (VAT), the changes which are often mitigated when oestradiol is added back ( 18 , 19 ). As a bidirectional relationship exists between excess VAT and the many
Jairo Arturo Pinzón-Cortés
Jairo Arturo Pinzón-Cortés
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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Angelina Perna-Chaux
Angelina Perna-Chaux
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Nicolás Steven Rojas-Villamizar
Nicolás Steven Rojas-Villamizar
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Angélica Díaz-Basabe
Angélica Díaz-Basabe
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Diana Carolina Polanía-Villanueva
Diana Carolina Polanía-Villanueva
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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María Fernanda Jácome
María Fernanda Jácome
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Carlos Olimpo Mendivil
Carlos Olimpo Mendivil
School of Medicine, Universidad de los Andes, Bogotá, Colombia
Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia
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Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia
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Helena Groot
Helena Groot
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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Valeriano López-Segura
Valeriano López-Segura
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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experiments; GSE21232 (pancreatic islets), GSE34008 (whole blood), GSE38291 (muscle and adipose tissue), GSE20067 (whole blood), GSE57285 (healthy control), GSE61611 (healthy control), 18 Illumina Human Ref-8 v3.0 expression BeadChips and 18 Exiqon miRCURY LNA
Hichem Bouguerra
Hichem Bouguerra
Université Tunis El-Manar, Faculté des Sciences de Tunis, Laboratoire de Génétique, Immunologie et pathologies Humaines, Tunis, Tunisie
Université Côte d'Azur, INSERM, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France
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Université Côte d'Azur, INSERM, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France
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Gorrab Amal
Gorrab Amal
Université Tunis El-Manar, Faculté des Sciences de Tunis, Laboratoire de Génétique, Immunologie et pathologies Humaines, Tunis, Tunisie
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Stephan Clavel
Stephan Clavel
Université Côte d'Azur, INSERM, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France
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Hamouda Boussen
Hamouda Boussen
Département d’Oncologie Médicale, Hôpital Abderrahman Mami, Ariana, Tunisia
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Jean-François Louet
Jean-François Louet
Université Côte d'Azur, INSERM, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France
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Asma Gati
Asma Gati
Université Tunis El-Manar, Faculté des Sciences de Tunis, Laboratoire de Génétique, Immunologie et pathologies Humaines, Tunis, Tunisie
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oxidation through up-regulation of PGC1A. Discussion The excessive accumulation of adipose tissue in obesity has been linked to poorer prognosis in BC ( 10 ). The stromal cells in a breast tumor microenvironment are mainly composed of
Anouar Aznou
Anouar Aznou
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Rick Meijer
Rick Meijer
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Daniel van Raalte
Daniel van Raalte
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Martin den Heijer
Martin den Heijer
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Annemieke Heijboer
Annemieke Heijboer
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Renate de Jongh
Renate de Jongh
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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obese children and adolescents ( 10 ) have been described. These studies are, however, inconsistent in the presence and the direction of the association ( 11 ). Adipose tissue appears to be involved in the association between Wnt signalling and insulin
Ruixin Hu
Ruixin Hu
School of pharmacy, Qing Dao University, Qingdao, China
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Yanting Yuan
Yanting Yuan
School of pharmacy, Qing Dao University, Qingdao, China
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Chaolong Liu
Chaolong Liu
School of pharmacy, Qing Dao University, Qingdao, China
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Ji Zhou
Ji Zhou
School of pharmacy, Qing Dao University, Qingdao, China
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Lixia Ji
Lixia Ji
School of pharmacy, Qing Dao University, Qingdao, China
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Guohui Jiang
Guohui Jiang
School of pharmacy, Qing Dao University, Qingdao, China
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the blood, omental, subcutaneous and mesenteric adipose tissue in T2DM patients. A small amount of bacterial DNA can increase the expression of pro-inflammatory factors in subcutaneous adipocytes. As a ‘barrier’ for bacteria to enter the body from the
Esben Thyssen Vestergaard
Esben Thyssen Vestergaard
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Morten B Krag
Morten B Krag
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Morten M Poulsen
Morten M Poulsen
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Steen B Pedersen
Steen B Pedersen
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Niels Moller
Niels Moller
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Jens Otto Lunde Jorgensen
Jens Otto Lunde Jorgensen
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Niels Jessen
Niels Jessen
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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pmol/kg per min) or a saline infusion. Three of the subjects had subcutaneous (periumbilical) adipose tissue biopsies by liposuction technique at t =120 min after applying local analgesic of 10 ml lidocaine (xylocaine 10 mg/ml; AstraZeneca). A
