Ann-Kristin Picke
Ann-Kristin Picke
Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany
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Graeme Campbell
Graeme Campbell
Institute of Biomechanics, TUHH Hamburg University of Technology, Hamburg, Germany
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Nicola Napoli
Nicola Napoli
Diabetes and Bone Network, Department Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy
Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA
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Division of Bone and Mineral Diseases, Washington University in St Louis, St Louis, Missouri, USA
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Lorenz C Hofbauer
Lorenz C Hofbauer
Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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Martina Rauner
Martina Rauner
Department of Medicine III & Center for Healthy Aging, Technische Universität Dresden, Dresden, Germany
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) The number and function of bone-forming osteoblast is reduced. In addition, vitamin D serum levels are decreased, which alters calcium and phosphate homeostasis. (2) Osteoblasts derive from MSC that favor differentiating into fat-storing adipocytes in
Liangming Li
Liangming Li
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Yuan Wei
Yuan Wei
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Chunlu Fang
Chunlu Fang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Shujing Liu
Shujing Liu
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Fu Zhou
Fu Zhou
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Ge Zhao
Ge Zhao
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Yaping Li
Yaping Li
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Yuan Luo
Yuan Luo
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Ziyi Guo
Ziyi Guo
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Weiqun Lin
Weiqun Lin
Department of Clinical Nutrition, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
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Wenqi Yang
Wenqi Yang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sport University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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tissue fibrosis ( 7 , 8 ). Adipocytes are surrounded by a network of extracellular matrix (ECM) mainly composed of collagens and fibronectin. Adipose fibrosis is defined as an excessive accumulation of ECM components ( 9 ). It has been demonstrated
Shane M Regnier
Shane M Regnier
Committee on Molecular Metabolism and Nutrition, Chicago, Illinois, USA
Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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Andrew G Kirkley
Andrew G Kirkley
University of Chicago, Chicago, Illinois, USA
Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA
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Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA
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Daniel Ruiz
Daniel Ruiz
Committee on Molecular Metabolism and Nutrition, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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University of Chicago, Chicago, Illinois, USA
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Wakanene Kamau
Wakanene Kamau
University of Chicago, Chicago, Illinois, USA
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Qian Wu
Qian Wu
Wadsworth Center, New York Department of Health, Albany, New York, USA
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Kurunthachalam Kannan
Kurunthachalam Kannan
Wadsworth Center, New York Department of Health, Albany, New York, USA
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Robert M Sargis
Robert M Sargis
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
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adiposity relative to the HFHSD controls ( Fig. 2C ). Histologic analysis of perigonadal/epididymal adipose tissue identified a significant increase in the number of adipocytes per high-power field (hpf) in the TF-treated group ( Fig. 2D ). Despite this
E M Winter
E M Winter
Leiden University Medical Center, Department of Internal Medicine, Division of Endocrinology, Center for Bone Quality, Leiden, the Netherlands
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A Ireland
A Ireland
Musculoskeletal Science and Sports Medicine Research Centre, Department of Life Sciences, Manchester Metropolitan University, Manchester, United Kingdom
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N C Butterfield
N C Butterfield
Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, DuCane Road, London, United Kingdom
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M Haffner-Luntzer
M Haffner-Luntzer
Institute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, Ulm, Germany
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M-N Horcajada
M-N Horcajada
Nestlé Research, Department of Musculoskeletal Health, Innovation EPFL Park, Lausanne, Switzerland.
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A G Veldhuis-Vlug
A G Veldhuis-Vlug
Leiden University Medical Center, Department of Internal Medicine, Division of Endocrinology, Center for Bone Quality, Leiden, the Netherlands
Jan van Goyen Medical Center, Department of Internal Medicine, Amsterdam, the Netherlands
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Jan van Goyen Medical Center, Department of Internal Medicine, Amsterdam, the Netherlands
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L Oei
L Oei
Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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G Colaianni
G Colaianni
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
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N Bonnet
N Bonnet
Nestlé Research, Department of Musculoskeletal Health, Innovation EPFL Park, Lausanne, Switzerland.
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nervous system (SNS), which increases release of neurotransmitters such as norepinephrine, stimulates bone resorption through an enhanced RANKL secretion by osteoblasts (OBs). In the bone marrow adipose tissue (BMAT), adipocytes undergo lipolysis to
Anouar Aznou
Anouar Aznou
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Rick Meijer
Rick Meijer
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Daniel van Raalte
Daniel van Raalte
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Martin den Heijer
Martin den Heijer
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Annemieke Heijboer
Annemieke Heijboer
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Renate de Jongh
Renate de Jongh
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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sensitivity, but also hypertrophy of adipocytes and an overall increase in body fat mass ( 15 ). In south Asian men, both increased serum sclerostin levels and decreased expression of insulin signalling genes in white adipose tissue were found ( 28 ). Also
Wenqi Yang
Wenqi Yang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Ling Liu
Ling Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Yuan Wei
Yuan Wei
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Chunlu Fang
Chunlu Fang
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Fu Zhou
Fu Zhou
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Jinbao Chen
Jinbao Chen
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qinghua Han
Qinghua Han
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Meifang Huang
Meifang Huang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xuan Tan
Xuan Tan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiuyue Liu
Qiuyue Liu
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Qiang Pan
Qiang Pan
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Lu Zhang
Lu Zhang
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Xiaojuan Lei
Xiaojuan Lei
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Liangming Li
Liangming Li
Center for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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adipocyte ( 23 )) and a significant reduction in F4/80 mRNA levels ( Fig. 5A and B ). HFD feeding increased the expression of proinflammatory cytokines TNFα, IL-1β, IL-6 and MCP-1, which was largely prevented by exercise training ( Fig. 5B ). Figure 5
Estíbaliz Castillero
Estíbaliz Castillero
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Ana Isabel Martín
Ana Isabel Martín
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Maria Paz Nieto-Bona
Maria Paz Nieto-Bona
Department of Physiology, Department of Histology, Faculty of Medicine, Complutense University of Madrid, 28040 Madrid, Spain
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Carmen Fernández-Galaz
Carmen Fernández-Galaz
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María López-Menduiña
María López-Menduiña
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María Ángeles Villanúa
María Ángeles Villanúa
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Asunción López-Calderón
Asunción López-Calderón
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glucose metabolism by inhibiting gluconeogenesis in the liver and maintaining systemic lipid and insulin-dependent muscle glucose uptake. It has been reported that arthritic rats have reduced adipocyte size and downregulated membrane glucose transporter
Emanuela Zaharieva
Emanuela Zaharieva
Department of Internal Medicine, University Hospital Alexandrovska, Clinic of Endocrinology, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria
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Zdravko Kamenov
Zdravko Kamenov
Department of Internal Medicine, University Hospital Alexandrovska, Clinic of Endocrinology, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria
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Tsvetelina Velikova
Tsvetelina Velikova
Department of Clinical Immunology, University Hospital St. Ivan Rilski, Laboratory of Clinical Immunology, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria
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Adelina Tsakova
Adelina Tsakova
Department of Clinical Laboratory, University Hospital Alexandrovska, Central Clinical Laboratory, Faculty of Medicine, Medical University-Sofia, Sofia, Bulgaria
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Yosif El-Darawish
Yosif El-Darawish
Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Hyogo, Japan
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Haruki Okamura
Haruki Okamura
Laboratory of Tumor Immunology and Cell Therapy, Hyogo College of Medicine, Hyogo, Japan
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major contributor to inflammatory cytokine release in these states ( 23 ). As with other adipokines ( 24 , 25 ), adipocytes can produce IL-18 ( 26 , 27 ), but they do not seem to be the main source of the interleukin – rather it is being predominantly
Eric M Ndombi
Eric M Ndombi
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Valentine Budambula
Valentine Budambula
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Mark K Webale
Mark K Webale
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Francis O Musumba
Francis O Musumba
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Jesca O Wesongah
Jesca O Wesongah
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Erick Mibei
Erick Mibei
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Aabid A Ahmed
Aabid A Ahmed
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Raphael Lihana
Raphael Lihana
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Tom Were
Tom Were
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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.5 kg/m 2 ), lower body weight and fat mass in HIV-infected and uninfected IDUs (13, 14) , indicate that anthropometric measures are valuable in estimating adiposity in IDUs. In addition, the link between lipodystrophy and adipocyte dysfunction (15
Nannan Bian
Nannan Bian
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Xiaomeng Sun
Xiaomeng Sun
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Biao Zhou
Biao Zhou
Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
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Lin Zhang
Lin Zhang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Qiu Wang
Qiu Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yu An
Yu An
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Xiaohui Li
Xiaohui Li
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yinhui Li
Yinhui Li
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Hua Meng
Hua Meng
Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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-body metabolism. Adipocytes release multiple anti-inflammatory and pro-inflammatory cytokines. A low degree of inflammation is a link between IR and obesity. Studies showed that elevated proinflammatory cytokines TNF-α and IL-6 impaired insulin receptor substrate
