Ann-Cathrin Koschker
Ann-Cathrin Koschker
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Bodo Warrings
Bodo Warrings
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Caroline Morbach
Caroline Morbach
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Florian Seyfried
Florian Seyfried
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Nicole Rickert
Nicole Rickert
Department of Radiology, University Hospital, University of Würzburg, Würzburg, Germany
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Pius Jung
Pius Jung
Division of Pneumology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Andreas Geier
Andreas Geier
Division of Hepatology, Department of Internal Medicine II, University Hospital, University of Würzburg, Würzburg, Germany
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Ulrich Dischinger
Ulrich Dischinger
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Maike Krauthausen
Maike Krauthausen
Department of General Practice, University Hospital, University of Würzburg, Würzburg, Germany
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Martin J Herrmann
Martin J Herrmann
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Christine Stier
Christine Stier
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Stefan Frantz
Stefan Frantz
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Uwe Malzahn
Uwe Malzahn
Center for Clinical Trials, University Hospital, University of Würzburg, Würzburg, Germany
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Stefan Störk
Stefan Störk
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Martin Fassnacht
Martin Fassnacht
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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the WAS Study Group
the WAS Study Group
the WAS Study Group
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. documentation of concomitant drugs) Open and standardized questions Obesity-related comorbidities Comprehensive laboratory assessment Blood analysis a For example, adverse events and comorbidities Obstructive sleep apnea screening Apnea
Athanasios Zervas
Athanasios Zervas
Endocrine Unit, Athens Medical Centre, Athens, Greece
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George Chrousos
George Chrousos
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, Athens, Greece
National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece
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National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece
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Sarantis Livadas
Sarantis Livadas
Endocrine Unit, Athens Medical Centre, Athens, Greece
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probably from sleep apnea. Finally, Dopey’s absence of beard is compatible with hypogonadism, therefore, he most probably exemplifies the most severe form of the disorder affecting all members of this family. We are, therefore, searching for a genetic
Rama Lakshman
Rama Lakshman
Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
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Charlotte Boughton
Charlotte Boughton
Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
Cambridge University Hospitals NHS Foundation Trust, Wolfson Diabetes and Endocrine Clinic, Cambridge, UK
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Cambridge University Hospitals NHS Foundation Trust, Wolfson Diabetes and Endocrine Clinic, Cambridge, UK
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Roman Hovorka
Roman Hovorka
Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
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/L and no autocorrections Ease-off mode: target 7 mmol/L, less insulin delivery ~−35% Sleep Activity: target 6.25–6.7 mmol/L basal rate modulation only; Activity mode: target +3.8 mmol/L and less aggressive algorithm Activity mode: target 8.3 mmol
Christine Poitou
Christine Poitou
Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service de Nutrition, Hôpital Pitié-Salpêtrière, Paris, France
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Anthony Holland
Anthony Holland
Department of Psychiatry, University of Cambridge, UK
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Charlotte Höybye
Charlotte Höybye
Department of Endocrinology and Department of Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
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Laura C G de Graaff
Laura C G de Graaff
Center for Adults with Rare Genetic Syndromes, Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Sandrine Bottius
Sandrine Bottius
Assistance Publique-Hôpitaux de Paris, Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service de Nutrition, Hôpital Pitié-Salpêtrière, Paris, France
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Berit Otterlei
Berit Otterlei
Landsforeningen for Prader-Willis Syndrom Hiltonåsen, Slependen, Norway
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Maithé Tauber
Maithé Tauber
Centre de référence Maladies Rares (PRADORT, Syndrome de Prader-Willi et autres formes rares d’obésité avec troubles du comportement alimentaire), Service d’Endocrinologie, Obésités, Maladies Osseuses, Génétique et Gynécologie Médicale, Hôpital des Enfants, Toulouse, France
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, uncontrolled access to food may be allowed substantial weight gain will occur, resulting in physical consequences, such as diabetes mellitus and sleep apnea. Managing the transition to adult life with people with neurodevelopmental syndromes, such as PWS
Marieke Stientje Velema
Marieke Stientje Velema
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Aline de Nooijer
Aline de Nooijer
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Ad R M M Hermus
Ad R M M Hermus
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Henri J L M Timmers
Henri J L M Timmers
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
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Jacques W M Lenders
Jacques W M Lenders
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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Olga Husson
Olga Husson
Division of Clinical Studies, Institute of Cancer Research, London, UK
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Jaap Deinum
Jaap Deinum
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technical University Dresden, Dresden, Germany
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.45** 0.45** 0.75** 0.21 0.50** Nausea/vomiting 0.54** 0.30* 0.30* 0.39** 0.20 0.26 Pain 0.60** 0.29 0.13 0.36* 0.06 0.30* Dyspnea 0.63** 0.26 0.27 0.52** 0.06 0.30* Sleep/insomnia 0
Julie M Silverstein
Julie M Silverstein
Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8127, St Louis, Missouri 63110, USA
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, arthralgia, and soft tissue changes, and comorbidities include hypertension, type 2 diabetes, sleep apnea, and carpal tunnel syndrome (2, 9, 10) . If left untreated, long-term exposure to GH/IGF1 hypersecretion in patients with acromegaly can be associated
Kim K B Clemmensen
Kim K B Clemmensen
Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark
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Jonas S Quist
Jonas S Quist
Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark
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Dorte Vistisen
Dorte Vistisen
Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark
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Daniel R Witte
Daniel R Witte
Department of Public Health, Aarhus University, Aarhus, Denmark
Danish Diabetes Academy, Odense, Denmark
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Danish Diabetes Academy, Odense, Denmark
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Anna Jonsson
Anna Jonsson
NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
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Oluf Pedersen
Oluf Pedersen
NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
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Torben Hansen
Torben Hansen
NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
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Jens J Holst
Jens J Holst
NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Torsten Lauritzen
Torsten Lauritzen
Section for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark
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Marit E Jørgensen
Marit E Jørgensen
Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
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National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
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Signe Torekov
Signe Torekov
NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
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Kristine Færch
Kristine Færch
Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark
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GLP-1 and GIP has been shown to exhibit a circadian pattern, with lower levels in the morning and higher levels in the late afternoon ( 9 , 10 ). The timing of sleep and meals shows variation over the week, with other activity patterns in the
Lang Qin
Lang Qin
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Xiaoming Zhu
Xiaoming Zhu
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Xiaoxia Liu
Xiaoxia Liu
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Meifang Zeng
Meifang Zeng
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Ran Tao
Ran Tao
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yan Zhuang
Yan Zhuang
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yiting Zhou
Yiting Zhou
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Shanghai Pituitary Tumor Center, Shanghai, China
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Shanghai Pituitary Tumor Center, Shanghai, China
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Yehong Yang
Yehong Yang
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yiming Li
Yiming Li
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yongfei Wang
Yongfei Wang
Division of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Shanghai Pituitary Tumor Center, Shanghai, China
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Shanghai Pituitary Tumor Center, Shanghai, China
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Hongying Ye
Hongying Ye
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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output, total peripheral resistance and renovascular resistance; insulin resistance and sleep apnea. In adult patients with Cushing’s syndrome (CS), hypertension is present in 70–85% of patients; after surgical treatment, approximately 30% of adults
Susan M Webb
Susan M Webb
IIB-Sant Pau, Research Center for Pituitary Diseases, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Spain
Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Spain
Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Jette Kristensen
Jette Kristensen
ePAG & Chair of Danish Addison Patient Association, Aarhus, Denmark
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Anna Nordenström
Anna Nordenström
Pediatric Endocrinology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
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Diana Vitali
Diana Vitali
ePAG & Chair SOD ITALIA - Italian Patients Organization for Septo Optic Dysplasia and other Neuroendocrine Conditions, Rome, Italy
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Vincent Amodru
Vincent Amodru
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics, Institut MarMaRa, Marseille, France
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Lenja Katharina Wiehe
Lenja Katharina Wiehe
EURORDIS - Rare Diseases Europe, Paris, France
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Matt Bolz-Johnson
Matt Bolz-Johnson
EURORDIS - Rare Diseases Europe, Paris, France
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, appearance of more body hair, snoring or sleep apnea, weight gain, skin thickening, jaw growth with toothache, high blood pressure Feeling ‘something is wrong’ Psychological: insomnia, lack of concentration, less memory, unreasonable nervousness, depression
Patricia Arroyo Tardio
Patricia Arroyo Tardio
University Hospital Basel, Basel, Switzerland
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Gabriela Baldini
Gabriela Baldini
University Clinic of Medicine, Cantonal Hospital Baselland, Liestal, Switzerland
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Eleonora Seelig
Eleonora Seelig
University Hospital Basel, Basel, Switzerland
University Clinic of Medicine, Cantonal Hospital Baselland, Liestal, Switzerland
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University Clinic of Medicine, Cantonal Hospital Baselland, Liestal, Switzerland
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Weibel L Follenius M Spiegel K Ehrhart J & Brandenberger G . Comparative effect of night and daytime sleep on the 24-hour cortisol secretory profile . Sleep 1995 18 549 – 556 . 14 Wilhelm I Born J Kudielka BM Schlotz W & Wust S
