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  • nonalcoholic fatty liver disease x
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Christin Krause Epigenetics & Metabolism, Medical Department I, University of Lübeck, Lübeck, Germany

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Martina Grohs Epigenetics & Metabolism, Medical Department I, University of Lübeck, Lübeck, Germany

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Alexander T El Gammal Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Stefan Wolter Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Hendrik Lehnert Medical Department I, University of Lübeck, Lübeck, Germany

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Oliver Mann Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Jens Mittag Molecular Endocrinology, Medical Department I, University of Lübeck, Lübeck, Germany

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Henriette Kirchner Epigenetics & Metabolism, Medical Department I, University of Lübeck, Lübeck, Germany

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Introduction Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in Western countries, affecting for instance more than 10% of all adults in the United States. NAFLD encompasses a wide spectrum of different stages

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0499
Volume/Issue:
Volume 7: Issue 12
Open access
Antonia Ertelt Equine Clinic, Free University of Berlin, Berlin, Germany

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Ann-Kristin Barton Equine Clinic, Free University of Berlin, Berlin, Germany

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Robert R Schmitz Equine Clinic, Free University of Berlin, Berlin, Germany

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Heidrun Gehlen Equine Clinic, Free University of Berlin, Berlin, Germany

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evidence of sinking of the coffin bone. Figure 3 Lateromedial radiographic image of a physiological positioned hoof with no evidence of rotation or sinking of the coffin bone. Another consequence of HMS is non-alcoholic fatty liver disease. Pathological

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-14-0038
Volume/Issue:
Volume 3: Issue 3
Open access
Monika Karczewska-Kupczewska Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Agnieszka Nikołajuk Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland

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Magdalena Stefanowicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Natalia Matulewicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Irina Kowalska Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Marek Strączkowski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland

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circulating chemerin concentration has been reported in obesity ( 8 , 9 , 10 ) and related comorbidities such as metabolic syndrome ( 11 ), nonalcoholic fatty liver disease (NAFLD) ( 12 ) and type 2 diabetes ( 9 , 13 ). Systemic chemerin concentrations

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0084
Volume/Issue:
Volume 9: Issue 5
Open access
Magnolia Ariza-Nieto Cornell University, Meinig School of Biomedical Engineering, Ithaca, New York, USA
epiWELL, LLC, Ithaca, New York, USA

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Joshua B Alley Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Sanjay Samy Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Laura Fitzgerald Donald Guthrie Foundation for Education and Research, Guthrie Clinic, Sayre, Pennsylvania, USA

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Francoise Vermeylen Cornell University, Cornell Statistical Consulting Unit, Ithaca, New York, USA

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Michael L Shuler Cornell University, Meinig School of Biomedical Engineering, Ithaca, New York, USA

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José O Alemán New York University Langone Medical Center, New York, New York, USA

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as glucose homeostasis and fatty acid oxidation. Further, it has been well documented that the liver function is influenced by signaling interactions with adipose tissue ( 7 , 8 ). Specifically, DNA methyltransferase 1 (DNMT1) has been described as a

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0205
Volume/Issue:
Volume 7: Issue 9
Open access
Pernille H Hellmann Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jonatan I Bagger Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Katrine R Carlander Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Katrine B Hansen Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Julie L Forman Section of Biostatistics, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Joachim Størling Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Elizaveta Chabanova Department of Radiology, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Jens Holst Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Tina Vilsbøll Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Filip K Knop Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Sensitivity Check Index, fasting glucose and insulin levels in several clinical studies in individuals with impaired glucose tolerance, obesity, type 2 diabetes and non-alcoholic fatty liver disease, respectively, not caused by glucocorticoids ( 28 , 29 , 36

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0334
Volume/Issue:
Volume 12: Issue 4
Open access
Arpna Sharma Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Vijay Simha Baddela Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Frank Becker Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Dannenberger Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Jens Vanselow Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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often observed in obese women ( 8 ). However, on the contrary, OA (monounsaturated fatty acid) supplementation has shown to protect exocrine pancreatic cells from PA-induced apoptosis thus reducing the rate of pancreatic diseases caused by obesity ( 9

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0011
Volume/Issue:
Volume 8: Issue 5
Open access
Barbara J Boucher The Blizard Institute, Queen Mary University of London, London, UK

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features ( 47 ). The severity of non-alcoholic fatty liver disease, common in diabetes and obesity, relates inversely to vitamin D status, no doubt because both obesity and liver damage will reduce 25-hydroxylation of vitamin D ( 48 , 49 , 50 ). As in any

Article Type:
Review Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-22-0234
Volume/Issue:
Volume 11: Issue 12
Open access
Tao Gao Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Rui Liu Department of Oncology. The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Chunli Li Institute of Life Sciences, Chongqing Medical University, Chongqing, China

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Xinglin Chu Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Qiao Guo Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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Dazhi Ke Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

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studies have shown that fetuin-B is closely related to obesity and metabolic syndrome and can lead to lipid metabolism disorders. In a clinical case–control study, it was found that people with nonalcoholic fatty liver disease (NAFLD) had an increased

Article Type:
Research Article
Collections:
Cardiovascular
DOI:
https://doi.org/10.1530/EC-23-0172
Volume/Issue:
Volume 12: Issue 12
Open access
Xiuzhen Hou Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China

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Junfeng Zhang Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China

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Hehong Ma Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China

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Ming Li Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China

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Pei Wang Division 1 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China

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T Holst JJ Svare JA Clausen TD Nonalcoholic fatty liver disease is prevalent in women with prior gestational diabetes mellitus and independently associated with insulin resistance and waist circumference . Diabetes Care 2017 40 109

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0555
Volume/Issue:
Volume 10: Issue 1
Open access
Magnus F G Grøndahl Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Jonatan I Bagger Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Malte P Suppli Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Gerrit Van Hall Department of Clinical Biochemistry, Clinical Metabolomics Core Facility, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Nicolai J W Albrechtsen Department of Clinical Biochemistry, University Hospital Copenhagen, Bispebjerg, Copenhagen, Denmark

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Jens J Holst Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Tina Vilsbøll Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Mikkel B Christensen Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Pharmacology, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen, Denmark
Copenhagen Center for Translational Research, Copenhagen University Hospital – Bispebjerg and Frederiksberg, University of Copenhagen, Copenhagen, Denmark

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Asger B Lund Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Filip K Knop Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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of glucagon, hyperglucagonaemia, are observed in several obesity-related diseases including type 2 diabetes and non-alcoholic fatty liver disease where it contributes to an increased risk of hyperglycaemia ( 3 , 4 , 5 , 6 , 7 , 8 , 9 ). The

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0516
Volume/Issue:
Volume 13: Issue 3
Open access