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Anne H van der Spek Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Olga V Surovtseva Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Saskia Aan Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Anton T J Tool Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Annemarie van de Geer Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Korcan Demir Division of Pediatric Endocrinology, Dokuz Eylül University, Izmir, Turkey

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Anja L M van Gucht Department of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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A S Paul van Trotsenburg Department of Pediatric Endocrinology, Academic Medical Center, Amsterdam, The Netherlands

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Timo K van den Berg Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Anita Boelen Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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CXCL8 (interleukin-8 (IL-8)) were published previously ( 40 , 41 , 42 , 43 ). Primer sequences for IL1B (interleukin-1β (IL-1β)) and IL6 (interleukin-6 (IL-6)) were derived from the Harvard Primer Bank (numbers 221139821c1, 27894305c1 and

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Wang-shu Liu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Ling-yan Hua Department of Ophthalmology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Su-xiang Zhu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Feng Xu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Xue-qin Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Chun-feng Lu Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Jian-bin Su Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Feng Qi Emergency Intensive Care Unit, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Introduction The rising prevalence of type 2 diabetes (T2D) has posed a great threat to public health, affecting approximately 400 million people in 2017 ( 1 ). Uncontrolled and untreated T2D may lead to a variety of chronic complications ( 2

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Marra Jai Aghajani Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia

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Tara Laurine Roberts Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia

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Tao Yang School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia
SydPath, Saint Vincent’s Hospital, Sydney, Australia

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Charles Eugenio McCafferty Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia

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Nicole J Caixeiro Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Centre for Oncology Education and Research Translation (CONCERT), Liverpool, New South Wales, Australia

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Paul DeSouza Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
South West Sydney Clinical School, UNSW Sydney, Sydney, Australia

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Navin Niles Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia
School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia
Department of Head & Neck Surgery, Liverpool Hospital, Liverpool, New South Wales, Australia
Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

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forms of these ligands. Blocking experiments confirmed their role in suppressing T cell proliferation, interleukin-2 (IL-2) secretion, inducing hypo-responsiveness and cell death. Thus, soluble PD-1 ligands play an important role in modulating T cell

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Anna C Simcocks Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia

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Kayte A Jenkin Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
School of Science and Health, Western Sydney University, Campbelltown, New South Wales, Australia

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Lannie O’Keefe Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia

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Chrishan S Samuel Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia

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Michael L Mathai Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Victoria, Australia

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Andrew J McAinch Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
Australian Institute for Musculoskeletal Science (AIMSS), College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia

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Deanne H Hryciw Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
School of Environment and Sciences, Griffith University, Nathan, Queensland, Australia

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-γ), interleukin 1 alpha (IL-1α), interleukin 1 beta (IL-1β), monocyte chemotactic protein 1 (MCP-1), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 17 alpha (IL-17α), interleukin 18 (IL

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B Shahida Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden

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P Sahlstrand Johnson Department of Oto-Rhino-Laryngology, Skåne University Hospital, Malmö, Sweden
Department of Clinical Sciences, Lund University, Malmö, Sweden

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R Jain Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden

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H Brorson Department of Clinical Sciences, Lund University, Malmö, Sweden
Department of Plastic Surgery, Skåne University Hospital, Malmö, Sweden

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P Åsman Department of Clinical Sciences Malmö, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden

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M Lantz Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden

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T Planck Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes and Endocrinology, Skåne University Hospital, Malmö, Sweden

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-CoA desaturase (Scd1)/Mm00446190_m1/; peroxisome proliferator-activated receptor-gamma (Ppar-γ)/Mm00440940_m1/; interleukin-6 (Il-6)/Mm00446190_m1/; and interleukin-1beta (Il-1b)/Mm00434228_m1/. The following assays were used in human OF’s: EGR1/Hs00152928_m1

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Aditya Dutta Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India

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Ganesh Jevalikar Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India

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Rutuja Sharma Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India

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Khalid J Farooqui Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India

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Shama Mahendru Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India

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Arun Dewan Institute of Internal Medicine, Max Healthcare, Saket, New Delhi, India

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Sandeep Bhudiraja Institute of Internal Medicine, Max Healthcare, Saket, New Delhi, India

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Ambrish Mithal Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India

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indirect effects (due to pro-inflammatory cytokine storm) on several endocrine organs and their axes have been elucidated ( 1 , 2 , 3 ). Hypothalamic–pituitary–thyroid (HPT) axis is an essential endocrine axis that regulates energy expenditure and

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Yao Ye Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Aurelia Vattai Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Nina Ditsch Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Christina Kuhn Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Martina Rahmeh Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Sven Mahner Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Myriam Ripphahn Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany

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Roland Immler Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany

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Markus Sperandio Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany

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Udo Jeschke Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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Viktoria von Schönfeldt Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany

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and pro-inflammatory cytokines is also induced in the endometrium of women with uRPL, such as interleukin 1beta, tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma) and transforming growth factor beta1 (TGF-beta1) ( 13 ). IL-1, TNF

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Qing Zhu Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Jianbin Su Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Xueqin Wang Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Mengjie Tang Department of Endocrinology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Yingying Gao Department of Rheumatology, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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Dongmei Zhang Clinical Medicine Research Center, Nantong City No 1 People’s Hospital and Second Affiliated Hospital of Nantong University, Jiangsu, China

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follicular cells produce interleukin-1 alpha and interleukin-6 . Clinical and Experimental Immunology 1989 77 324 – 330 . 21 Tracey KJ Cerami A . Tumor necrosis factor: a pleiotropic cytokine and therapeutic target . Annual Review of Medicine

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Anastasia K Armeni Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece

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Konstantinos Assimakopoulos Department of Psychiatry, University of Patras Medical School, Patras, Greece

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Dimitra Marioli Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece

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Vassiliki Koika Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece

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Euthychia Michaelidou Department of Biology, University of Patras, Patras, Greece

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Niki Mourtzi Department of Biology, University of Patras, Patras, Greece

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Gregoris Iconomou Department of Psychiatry, University of Patras Medical School, Patras, Greece

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Neoklis A Georgopoulos Division of Reproductive Endocrinology, Department of Obstetrics and Gynaecology, University of Patras Medical School, Patras, Greece

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women ( 57 ). A further study reported an association between the dopamine D4 receptor gene ( DRD4 ) with self-reports of sexual desire and arousal in 52 men and 92 women ( 58 ). Interleukin-1beta gene ( IL1B ) has been correlated with variation in

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Ozlem Atan Sahin Department of Pediatrics, Acıbadem University School of Medicine, Atasehir, Istanbul, Turkey

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Damla Goksen Department of Pediatric Endocrinology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey

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Aysel Ozpinar Department of Biochemistry, Acıbadem University, School of Medicine, Atasehir, Istanbul, Turkey

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Muhittin Serdar Department of Biochemistry, Acıbadem University, School of Medicine, Atasehir, Istanbul, Turkey

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Huseyin Onay Department of Medical Genetics, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey

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D Terzic IM Capkun V Peruzovic M Terzic J. FokI polymorphism, vitamin D receptor, and interleukin-1 receptor haplotypes are associated with type 1 diabetes in the dalmatian population . Journal of Molecular Diagnostics 2005 5

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