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/mL). Impairment to growth hormone–insulin-like growth factor-1 (GH/IGF1): children with growth retardation or adults with obvious hypometabolic syndrome had IGF1 levels below 2 s.d. than their peers and had additional pituitary hormone deficiencies. Impairment
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Introduction Congenital hypopituitarism (CH) is a rare disorder (incidence of 1:3500–10,000 births) defined by the deficiency of one or more pituitary hormones ( 1 , 2 ). Clinical presentation varies, ranging from isolated growth hormone
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health problem, as one billion people presented 25(OH)D deficiency ( 4 ), with a prevalence ranging from 2 to 90%, depending on cut-off points and selected population ( 5 ). In addition, Manson et al. ( 6 ), in 2016, in a re-analysis of IOM data
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. 25 Gertner JM Genel M Gianfredi SP Hintz RL Rosenfeld RG Tamborlane WV Wilson DM Prospective clinical trial of human growth hormone in short children without growth hormone deficiency . Journal of Pediatrics 1984 104 172 – 176
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Introduction Cranial diabetes insipidus (CDI) is due to the relative or absolute lack of the posterior pituitary hormone vasopressin (AVP), also known as anti-diuretic hormone (ADH). AVP is the major determinant of renal water resorption. AVP
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
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INSERM UMR_S933, Paris, France
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
INSERM UMR_S933, Paris, France
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isoenzyme 3b-HSD2 is an essential step for the biosynthesis of all steroids. Therefore, it plays a crucial role in aldosterone, cortisol and sex hormones production ( Fig. 1 ). Phenotypes encompass a continuum from mild-to-severe enzymatic deficiency. In the
EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
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EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
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EndoERN, APHP Consortium Pitie Salpetriere Hospital, Necker Hospital, Paris, France
Sorbonne University, Paris, France
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defined as an insufficient GH peak during insulin tolerance test (ITT) (severe GHD if GH peak < 10 mU/L; partial GHD if GH peak between 10 and 20 mU/L). According to 2007 consensus guidelines, patients with three or more pituitary hormone deficiencies and
Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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differentiation, and for the maintenance of some very specific cell functions such as photo-transduction. Vitamin A deficiency is a marker of malnutrition that correlates with infection and mortality in children and possibly in childbearing women. Vitamin A is
Universitat Oberta Catalunya (UOC), Barcelona, Spain
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Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain
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Univ Autònoma de Barcelona, Cerdanyola del Vallès, Spain
Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain
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Introduction Growth hormone deficiency (GHD) has been studied in neurological disorders affecting central nervous systems, such as multiple sclerosis to amyotrophic lateral sclerosis ( 1 , 2 ). Because of the direct impact to the pituitary
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Universidade de São Paulo, Zebrafish Facility, São Paulo, São Paulo, Brazil
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cell proliferation and differentiation ( 1 ). Defects in the genes that control these processes can cause congenital hypopituitarism, which is defined as the deficiency of one or more pituitary hormones. Congenital growth hormone deficiency (GHD