Huiyuan Zhai
Huiyuan Zhai
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Dongxu Wang
Dongxu Wang
Department of Geriatrics, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Yong Wang
Yong Wang
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Hongwei Gu
Hongwei Gu
Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Juan Jv
Juan Jv
Department of Cardiology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Liangliang Yuan
Liangliang Yuan
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Chao Wang
Chao Wang
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Leiyao Chen
Leiyao Chen
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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display heightened levels of circulating inflammatory markers such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), IL-1β, and monocyte chemoattractant protein 1 (MCP-1), as well as decreased plasma levels of anti-inflammatory cytokines
Athanasios D Anastasilakis
Athanasios D Anastasilakis
Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece
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Marina Tsoli
Marina Tsoli
1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Gregory Kaltsas
Gregory Kaltsas
1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Polyzois Makras
Polyzois Makras
Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece
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expression of cytokines and cellular adhesion molecules important for the migration and homing of LCs has been described ( 9 ). On the other hand, the infiltration of organs by a monoclonal cell population and the discovery of v-Raf murine sarcoma viral
Nikolaj Rittig
Nikolaj Rittig
Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark
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Mads Svart
Mads Svart
Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark
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Niels Jessen
Niels Jessen
Research Laboratory for Biochemical Pathology, Institute for Clinical Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Niels Møller
Niels Møller
Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark
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Holger J Møller
Holger J Møller
Department of Clinical Biochemistry Aarhus University Hospital, Aarhus C, Denmark
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Henning Grønbæk
Henning Grønbæk
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus C, Denmark
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transcription and release of a broad range of pro- and anti-inflammatory cytokines, e.g. TNF-α ( 11 , 12 ). Furthermore, the same mechanism leads to shedding of sCD163, which can be measured in the circulation as a robust marker of macrophage activation ( 13
Xiao-Shan Huang
Xiao-Shan Huang
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Ning Dai
Ning Dai
Zhejiang Chinese Medical University, Hangzhou, China
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Jian-Xia Xu
Jian-Xia Xu
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Jun-Yi Xiang
Jun-Yi Xiang
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Xiao-Zhong Zheng
Xiao-Zhong Zheng
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Tian-Yu Ke
Tian-Yu Ke
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Lin-Ying Ma
Lin-Ying Ma
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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Qi-Hao Shi
Qi-Hao Shi
Zhejiang Chinese Medical University, Hangzhou, China
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Shu-Feng Fan
Shu-Feng Fan
Department of Radiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
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inflammatory disorder characterized by chronic low-grade inflammation and excessive production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Experimental and clinical evidence suggests that chronic
Xuan Luo
Xuan Luo
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Tingting Zheng
Tingting Zheng
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Chaoming Mao
Chaoming Mao
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Xin Dong
Xin Dong
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Xiao Mou
Xiao Mou
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Chengcheng Xu
Chengcheng Xu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Qingyan Lu
Qingyan Lu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Baocui Liu
Baocui Liu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Shengjun Wang
Shengjun Wang
Department of Laboratory Immunology, Jiangsu University School of Medicine, Zhenjiang, China
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Yichuan Xiao
Yichuan Xiao
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
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, 13 ), the pathogenesis of HT remains unclear. During HT pathogenesis, the cytokine IL-1 has been reported to stimulate thyroid follicular cell (TFC) proliferation and produce other pro-inflammatory cytokines, such as IL-6 and IL-8, which in turn
Jakub Supronik
Jakub Supronik
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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Małgorzata Szelachowska
Małgorzata Szelachowska
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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Adam Kretowski
Adam Kretowski
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Katarzyna Siewko
Katarzyna Siewko
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
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proinflammatory cytokines such as interleukin-6 (IL6), IL12, or IL17 ( 8 , 9 ). Specific chemokines that are also related to the pathogenesis of this disease include C-X-C motif chemokine ligand 9 (CXCL9), CXCL10, CXCL11, and their receptor chemokine receptor
Qi Che
Qi Che
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Xirong Xiao
Xirong Xiao
Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
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Jun Xu
Jun Xu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Miao Liu
Miao Liu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Yongning Lu
Yongning Lu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Suying Liu
Suying Liu
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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Xi Dong
Xi Dong
Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China
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tumor tissues ( 6 ). IL-6 belongs to the main member of the IL-6 cytokine family and regulates multitudinous functions related to biological metabolism and immunity ( 7 ). Abnormal IL-6 cytokine expression and its aberrant downstream signaling activation
Qinglei Yin
Qinglei Yin
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Zhou Jin
Zhou Jin
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yulin Zhou
Yulin Zhou
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Dalong Song
Dalong Song
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Chenyang Fu
Chenyang Fu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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FengJiao Huang
FengJiao Huang
Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
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Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
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Shu Wang
Shu Wang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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related diseases. As indispensable components of immunity, CD4+ T lymphocytes play vital roles during the course of GD. The infiltration of T lymphocytes leads to the destruction of thyroid tissues, which synthesize proinflammatory cytokines to maintain
Antonia Ertelt
Antonia Ertelt
Equine Clinic, Free University of Berlin, Berlin, Germany
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Ann-Kristin Barton
Ann-Kristin Barton
Equine Clinic, Free University of Berlin, Berlin, Germany
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Robert R Schmitz
Robert R Schmitz
Equine Clinic, Free University of Berlin, Berlin, Germany
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Heidrun Gehlen
Heidrun Gehlen
Equine Clinic, Free University of Berlin, Berlin, Germany
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(MCP1 (CCL2)) and plasminogen activator inhibitor (PAI1 (SERPINE1)), as well as proinflammatory cytokines, such as tumor necrosis factor alpha (TNFα (TNF)), interleukin 1 (IL1 (IL1A)), IL6, and IL8 (CXCL8) (37, 38) . Differences in the production of
Zhaoxiang Liu
Zhaoxiang Liu
Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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Mingqiang Zhang
Mingqiang Zhang
Department of Respiratory and Critical Care Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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Xiaohu Shi
Xiaohu Shi
Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
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Wenhui Zhao
Wenhui Zhao
Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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Chenxiang Cao
Chenxiang Cao
Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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Lixia Jin
Lixia Jin
Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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Yanlei Wang
Yanlei Wang
Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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Jianzhong Xiao
Jianzhong Xiao
Department of Endocrinology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
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-grade inflammatory disease characterized by increased circulating concentrations of inflammatory cytokines and the recruitment of immune cells, including macrophages and T cells, to metabolic tissues ( 2 ). Myeloid-derived suppressor cells (MDSCs) represent a group
