Lang Qin
Lang Qin
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Xiaoming Zhu
Xiaoming Zhu
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Xiaoxia Liu
Xiaoxia Liu
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Meifang Zeng
Meifang Zeng
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Ran Tao
Ran Tao
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yan Zhuang
Yan Zhuang
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yiting Zhou
Yiting Zhou
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Shanghai Pituitary Tumor Center, Shanghai, China
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Shanghai Pituitary Tumor Center, Shanghai, China
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Yehong Yang
Yehong Yang
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yiming Li
Yiming Li
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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Yongfei Wang
Yongfei Wang
Division of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Shanghai Pituitary Tumor Center, Shanghai, China
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Shanghai Pituitary Tumor Center, Shanghai, China
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Hongying Ye
Hongying Ye
Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
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The 24-h UFC excretion, the overnight 1 mg dexamethasone suppression test (DST) and cortisol secretion circadian rhythm were used as the first-line screen tests to identify patients with CS after exclusion of exogenous glucocorticoids exposure
Ditte Sofie Dahl Sørensen
Ditte Sofie Dahl Sørensen
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Jesper Krogh
Jesper Krogh
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Åse Krogh Rasmussen
Åse Krogh Rasmussen
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Mikkel Andreassen
Mikkel Andreassen
Department of Endocrinology and Metabolism, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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profiles in adult patients with 21-hydroxylase deficiency have shown a substantial circadian rhythm highly influenced by glucocorticoid replacement ( 6 ). Most recent clinical guideline from the US Endocrine Society suggests levels of androstenedione and 17
Ferdinand Roelfsema
Ferdinand Roelfsema
Department of Internal Medicine, Section Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
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Peter Y Liu
Peter Y Liu
Department of Medicine, David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Los Angeles, California, USA
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Rebecca Yang
Rebecca Yang
Endocrine Research Unit, Mayo Clinic College of Medicine, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA
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Paul Takahashi
Paul Takahashi
Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
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Johannes D Veldhuis
Johannes D Veldhuis
Endocrine Research Unit, Mayo Clinic College of Medicine, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA
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impairs neurobehavioral, as well as metabolic and putatively reproductive health in aging ( 48 ). The earlier nocturnal rise in cortisol secretion likely reflects the timing of IL-2 administration rather than resetting of the circadian rhythm. Further
David P Sonne
David P Sonne
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Asger Lund
Asger Lund
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Jens Faber
Jens Faber
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Jens J Holst
Jens J Holst
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Tina Vilsbøll
Tina Vilsbøll
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Filip K Knop
Filip K Knop
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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Department of Medicine, Department of Biomedical Sciences, Department of Endocrinology, Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, DK-2900 Hellerup, Denmark
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responsible for TSH suppression under normal physiological circumstances. Finally, TSH concentrations display pronounced circadian changes – typically with nocturnal increases and daytime nadirs, which might also offer an explanation for the decline observed
Grethe Å Ueland
Grethe Å Ueland
Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
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Department of Medicine, Haukeland University Hospital, Bergen, Norway
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Thea Grinde
Thea Grinde
Department of Clinical Science, University of Bergen, Bergen, Norway
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Paal Methlie
Paal Methlie
Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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Oskar Kelp
Oskar Kelp
Department of Medicine, Akershus University Hospital, Nordbyhagen, Norway
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Kristian Løvås
Kristian Løvås
Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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Eystein S Husebye
Eystein S Husebye
Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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Department of Medicine, Haukeland University Hospital, Bergen, Norway
K. G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway
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the sulphation of DHEA to DHEAS may vary between individuals and increase variability; thus DHEA could perhaps be a substitute. However, assay of DHEA with its shorter half-life and circadian variation is not straight forward. Furthermore, the
Ramjan Sanas Mohamed
Ramjan Sanas Mohamed
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Biyaser Abuelgasim
Biyaser Abuelgasim
Imperial College School of Medicine, Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK
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Sally Barker
Sally Barker
Imperial College School of Medicine, Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK
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Hemanth Prabhudev
Hemanth Prabhudev
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Niamh M Martin
Niamh M Martin
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Karim Meeran
Karim Meeran
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Emma L Williams
Emma L Williams
Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK
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Sarah Darch
Sarah Darch
Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK
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Whitlock Matthew
Whitlock Matthew
Department of Biochemistry, Imperial College Healthcare NHS Trust, London, UK
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Tricia Tan
Tricia Tan
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK
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Florian Wernig
Florian Wernig
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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circadian rhythm of cortisol secretion whereby, in the evening, cortisol secretion is higher in CS patients than in normal subjects ( 4 ). Therefore, assessment of LNSC, without the impracticality of hospitalisation and disruption of a normal routine, would
Kuang Hung
Kuang Hung
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Bo-Ching Lee
Bo-Ching Lee
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Po-Ting Chen
Po-Ting Chen
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Kao-Lang Liu
Kao-Lang Liu
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Chin-Chen Chang
Chin-Chen Chang
Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Department and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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Department and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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Vin-Cent Wu
Vin-Cent Wu
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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Yen-Hung Lin
Yen-Hung Lin
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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appearance, unilateral abnormality, and bilateral abnormalities. AVS All AVS procedures were performed by an interventional radiologist with 15 years of experience and in the morning to avoid bias resulting from the circadian rhythms of aldosterone
Kamran Iqbal
Kamran Iqbal
Shire, London, UK
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Kate Halsby
Kate Halsby
pH Associates, Marlow, UK
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Robert D Murray
Robert D Murray
Leeds Centre for Diabetes & Endocrinology, St James’s University Hospital, Leeds, UK
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Paul V Carroll
Paul V Carroll
Department of Endocrinology, Guy’s & St. Thomas’ NHS Foundation Trust, London, UK
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Robert Petermann
Robert Petermann
Shire, Vienna, Austria
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primary AI, a mineralocorticoid analogue (fludrocortisone), with the aim to replace the missing cortisol and aldosterone, respectively. Conventional immediate-release (IR) HC does not replicate the physiological circadian rhythm of endogenous cortisol
Riccardo Pofi
Riccardo Pofi
Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK
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Ilaria Bonaventura
Ilaria Bonaventura
Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy
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Joanne Duffy
Joanne Duffy
Department of Clinical Chemistry and Immunology, Heartlands Hospital, Birmingham, UK
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Zoe Maunsell
Zoe Maunsell
Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
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Brian Shine
Brian Shine
Department of Clinical Biochemistry, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
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Andrea M Isidori
Andrea M Isidori
Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, Rome, Italy
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Jeremy W Tomlinson
Jeremy W Tomlinson
Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK
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prescribed MC since its discovery in 1954 ( 8 ). The pharmacokinetic characteristics of FC ( 9 ), alongside the ambition to mimic the physiological circadian secretion of aldosterone which is similar to that of cortisol ( 10 ), mean that it is usually taken
Jan W Eriksson
Jan W Eriksson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Reem A Emad
Reem A Emad
Department of Pharmacy, Uppsala University, Uppsala, Sweden
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Martin H Lundqvist
Martin H Lundqvist
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Niclas Abrahamsson
Niclas Abrahamsson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Maria C Kjellsson
Maria C Kjellsson
Department of Pharmacy, Uppsala University, Uppsala, Sweden
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, 17 , 20 ). The model diversity illustrated this phenomenon. It is, however, reassuring that the main model structure of the final model was similar to other published models ( 16 ), with the main differences being the lack of circadian rhythm ( 16
