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Samira M Sadowski Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland

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Emanuel Christ Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, Basel, Switzerland

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Benoit Bédat Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland

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Attila Kollár Department of Medical Oncology, Inselspital, University of Bern, Bern, Switzerland

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Wolfram Karenovics Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland

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Aurel Perren Institute of Pathology, University of Bern, Bern, Switzerland

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Frédéric Triponez Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland

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on behalf of the SwissNET registry
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diagnosed with liver and 3 with bone metastases at diagnosis. As for laboratory workup, data in the registry were incomplete. In 20 patients, median Chromogranin A was 60.8 (20–1773) µg/L, for a normal upper limit of 85 µg/L. In 9 patients, mean Neuron

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Anna Malczewska Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Magdalena Witkowska Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Karolina Makulik Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Agnes Bocian Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Agata Walter Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Joanna Pilch-Kowalczyk Department of Radiology and Nuclear Medicine, Medical University of Silesia, Katowice, Poland

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Wojciech Zajęcki Department of Pathology in Zabrze, Medical University of Silesia, Katowice, Poland

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Lisa Bodei Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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Kjell Oberg Department of Endocrine Oncology, University Hospital, Uppsala, Sweden

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Beata Kos-Kudła Department of Endocrinology and Neuroendocrine Tumors, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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clinically limited. Chromogranin A (CgA), previously considered the neuroendocrine pan-biomarker, reflects secretory activity rather than tumor biology, heterogeneity or plasticity ( 7 , 8 ). It has limited clinical utility as well as methodological

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Olof Joakim Pettersson Radiology and Molecular Imaging, Uppsala University Hospital, Uppsala, Sweden
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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Katarzyna Fröss-Baron Radiology and Molecular Imaging, Uppsala University Hospital, Uppsala, Sweden
Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Joakim Crona Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Anders Sundin Radiology and Molecular Imaging, Uppsala University Hospital, Uppsala, Sweden
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

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tumor grade at baseline were collected from the pathologists’ reports on biopsies of liver metastases or the primary PanNETs. Data on Chromogranin-A at baseline were obtained from the patients’ laboratory reports. Tumor measurements In each

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Myrtille Fouché Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Yves Bouffard Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Mary-Charlotte Le Goff Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Johanne Prothet Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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François Malavieille Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Pierre Sagnard Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Françoise Christin Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Davy Hayi-Slayman Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Arnaud Pasquer Department of Visceral Surgery, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Gilles Poncet Department of Visceral Surgery, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Thomas Walter Department of Hepatogastroenterology and Oncology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France

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Thomas Rimmelé Department of Anaesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France
EA 7426 Hospices Civils de Lyon-University Claude Bernard Lyon 1-Biomérieux ‘Pathophysiology of Injury-Induced Immunosuppression’ Pi3, Lyon, France

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Introduction Small-bowel neuroendocrine tumours (SB-NETs) are rare secreting neoplasms. Hormones (serotonin, histamine, bradykinin, prostaglandins and chromogranin-A) released into the systemic circulation can lead to a carcinoid syndrome (CS

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Liza Das Department of Endocrinology, Postgraduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India

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Kim Vaiphei Department of Histopathology, PGIMER, Chandigarh, India

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Ashutosh Rai Department of Translational and Regenerative Medicine, PGIMER, Chandigarh, India

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Chirag Kamal Ahuja Department of Radiology, PGIMER, Chandigarh, India

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Paramjeet Singh Department of Radiology, PGIMER, Chandigarh, India

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Ishani Mohapatra Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, India

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Rajesh Chhabra Department of Neurosurgery, PGIMER, Chandigarh, India

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Anil Bhansali Department of Endocrinology, Postgraduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India

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Bishan Dass Radotra Department of Histopathology, PGIMER, Chandigarh, India

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Ashley B Grossman Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Green Templeton College, University of Oxford, Oxford, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Pinaki Dutta Department of Endocrinology, Postgraduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India

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performed on paraffin-embedded tissue sections. Antigen retrieval was performed after deparaffinisation of tissue sections and sections were stained for the following antibodies: TTF-1, vimentin, EMA, S-100, GFAP, chromogranin A, Ki67, GH, PRL, TSH, LH, FSH

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Mirjana Kocova Department of Endocrinology and Genetics, Medical Faculty, University Pediatric Clinic, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

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Vesna Janevska Institute of Pathology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

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Violeta Anastasovska Genetic Laboratory, Medical Faculty, University Pediatric Clinic, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia

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tumor was performed in 2 patients who had a large tumor on ultrasonography. Slides were immunohistochemically stained with antibodies against alpha-inhibin, melanA, calretinin, synaptophysin, chromogranin, vimentin, CD56 and CD10 and analyzed on the

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Catherine Cardot Bauters CHU Lille, Service d’Endocrinologie, Diabétologie, Métabolisme-Nutrition, Hôpital Claude Huriez, Lille, France

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Emmanuelle Leteurtre Univ. Lille, Inserm, CHU Lille, UMR-S 1277-CANTHER, Cancer Heterogeneity, Plasticity & Resistance to Therapies, Lille, France

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Bruno Carnaille CHU Lille, Service de Chirurgie Endocrine, Hôpital Claude Huriez, Lille, France

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Christine Do Cao CHU Lille, Service d’Endocrinologie, Diabétologie, Métabolisme-Nutrition, Hôpital Claude Huriez, Lille, France

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Stéphanie Espiard CHU Lille, Service d’Endocrinologie, Diabétologie, Métabolisme-Nutrition, Hôpital Claude Huriez, Lille, France

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Malo Penven CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Evelyne Destailleur CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Isabelle Szuster CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Tonio Lovecchio CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Julie Leclerc Univ. Lille, Inserm, CHU Lille, UMR-S 1277-CANTHER, Cancer Heterogeneity, Plasticity & Resistance to Therapies, Lille, France
CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Fredéric Frénois Univ. Lille, CHU Lille, EA-7364 RADEME, Faculté de Médecine, Lille, France

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Emmanuel Esquivel Dept Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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Patricia L M Dahia Dept Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

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Emilie Ait-Yahya CHU Lille, Institut de Biochimie & Biologie Moléculaire, Centre de Biologie Pathologie Génétique, Lille, France

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Michel Crépin CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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Pascal Pigny CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France

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or adrenomedullary nodule. Plasma free normetanephrines were at the upper limit of the normal values. Pre-operatively, patient I-1 had high urinary normetanephrines (5x the upper limit range) and chromogranin-A levels (x3 the upper limit range). By

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Yiqiang Huang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Lin-ang Wang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Qiubo Xie Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Jian Pang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Luofu Wang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Yuting Yi Geneplus-Beijing Institute, Beijing, People’s Republic of China

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Jun Zhang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Yao Zhang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Rongrong Chen Geneplus-Beijing Institute, Beijing, People’s Republic of China

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Weihua Lan Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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Dianzheng Zhang Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA

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Jun Jiang Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China

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&E-stained tumor specimens ( Fig. 1 ) and tumor-specific expression of CgA (chromogranin A), Syn (synaptophysin), CD56 (neural cell adhesion molecule 1), S-100 (S100 calcium-binding protein B), CK (choline kinase beta), MelanA (protein melan-A), HMB45 (human

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Serena Martinelli Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Mario Maggi Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Elena Rapizzi Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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cells were treated with NGF, they were able to develop neurites and to express chromogranin A and PNMT. Despite the lack of hormone production, these cells might be useful for studying signalling pathways controlling growth and metastasis as well as for

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Majunath R Goroshi Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Swati S Jadhav Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Anurag R Lila Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Rajeev Kasaliwal Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Shruti Khare Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Chaitanya G Yerawar Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Priya Hira Department of Radiology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Uday Phadke Ruby Hall Clinic, Pune, Maharashtra, India

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Hina Shah Department of Nuclear Medicine and Positron Emission Tomography/Computed Tomography, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India

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Vikram R Lele Department of Nuclear Medicine and Positron Emission Tomography/Computed Tomography, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India

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Gaurav Malhotra Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, Annexe, Parel, Mumbai, Maharashtra, India

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Tushar Bandgar Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Nalini S Shah Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Introduction Ectopic adrenocorticotrophic hormone (ACTH) syndrome (EAS) is a rare disorder, accounting for 5–15% cases of endogenous Cushing’s syndrome (CS) ( 1 , 2 ). Although initially construed to be caused by malignant tumours (such as

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