Xiaobing Lu
Xiaobing Lu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Jiang Yue
Jiang Yue
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Qianjing Liu
Qianjing Liu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Shengyun He
Shengyun He
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Ying Dong
Ying Dong
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Ming Zhang
Ming Zhang
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Yicheng Qi
Yicheng Qi
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Minglan Yang
Minglan Yang
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Wang Zhang
Wang Zhang
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Hua Xu
Hua Xu
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Qing Lu
Qing Lu
Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Jing Ma
Jing Ma
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Introduction Obesity has become one of the greatest public health challenges nowadays. It is estimated that more than 50% of adults worldwide will be overweight or obese by 2030 ( 1 ). In China, the prevalence of overweight/obesity in adults
Anouar Aznou
Anouar Aznou
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Rick Meijer
Rick Meijer
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Daniel van Raalte
Daniel van Raalte
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Martin den Heijer
Martin den Heijer
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Annemieke Heijboer
Annemieke Heijboer
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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Renate de Jongh
Renate de Jongh
Department of Internal Medicine, Amsterdam University Medical Centers, MB Amsterdam, the Netherlands
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obese children and adolescents ( 10 ) have been described. These studies are, however, inconsistent in the presence and the direction of the association ( 11 ). Adipose tissue appears to be involved in the association between Wnt signalling and insulin
Jay Toulany
Jay Toulany
College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
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Sebastian D Parlee
Sebastian D Parlee
Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA
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Christopher J Sinal
Christopher J Sinal
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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Kathryn Slayter
Kathryn Slayter
Canadian Centre for Vaccinology, IWK Health Centre, Nova Scotia Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada
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Shelly McNeil
Shelly McNeil
Canadian Centre for Vaccinology, IWK Health Centre, Nova Scotia Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada
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Kerry B Goralski
Kerry B Goralski
College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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the right hand column. a A WHR ≥0.85 was used as the cutoff to define central obesity. b A BMI of ≥30 kg/m 2 to define obesity. The estimated glomerular filtration rate (eGFR) was determined from the measured serum creatinine concentration using
Nannan Bian
Nannan Bian
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Xiaomeng Sun
Xiaomeng Sun
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Biao Zhou
Biao Zhou
Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
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Lin Zhang
Lin Zhang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Qiu Wang
Qiu Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yu An
Yu An
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Xiaohui Li
Xiaohui Li
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yinhui Li
Yinhui Li
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Hua Meng
Hua Meng
Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Introduction The morbidity of overweight and obesity has increased globally ( 1 ). During 2013–2014 in the United States, obesity was 40.4% among women and 35% among men. The corresponding incidences for morbid obesity were 9.9% for women and
Franca Genest
Franca Genest
Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany
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Michael Schneider
Michael Schneider
Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany
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Andreas Zehnder
Andreas Zehnder
Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany
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Dominik Lieberoth-Leden
Dominik Lieberoth-Leden
Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany
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Lothar Seefried
Lothar Seefried
Clinical Trial Unit, Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany
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reported to be around 1–2% and 3%, respectively in men >60 years. Furthermore, a combination of sarcopenia with osteoporosis or obesity was assumed to worsen that effect ( 5 , 6 ). The combination of sarcopenia and low BMD reflected in the term
Eliana Piantanida
Eliana Piantanida
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Daniela Gallo
Daniela Gallo
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Giovanni Veronesi
Giovanni Veronesi
Department of Medicine and Surgery, University of Insubria, Varese, Italy
Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy
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Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy
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Eugenia Dozio
Eugenia Dozio
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Eugenia Trotti
Eugenia Trotti
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Adriana Lai
Adriana Lai
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Silvia Ippolito
Silvia Ippolito
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Jessica Sabatino
Jessica Sabatino
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Maria Laura Tanda
Maria Laura Tanda
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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Antonio Toniolo
Antonio Toniolo
Department of Biotechnology and Life Science, University of Insubria, Varese, Italy
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Marco Ferrario
Marco Ferrario
Department of Medicine and Surgery, University of Insubria, Varese, Italy
Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy
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Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy
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Luigi Bartalena
Luigi Bartalena
Department of Medicine and Surgery, University of Insubria, Varese, Italy
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calcium along with an increase in adipocyte fatty acid synthase and glycerol-3-phosphate dehydrogenase activities and lipolysis inhibition ( 28 ). Metabolic syndrome (MetS) is a multifactorial condition, having central obesity as a causative factor
L Bahler
L Bahler
Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
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H J Verberne
H J Verberne
Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
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E Brakema
E Brakema
Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
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R Tepaske
R Tepaske
Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands
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J Booij
J Booij
Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands
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J B Hoekstra
J B Hoekstra
Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
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F Holleman
F Holleman
Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
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. Recently, a quick release variant of bromocriptine has emerged as a new glucose-lowering treatment in obese patients with type 2 diabetes mellitus. Bromocriptine is a centrally acting dopamine D 2 -receptor agonist, but it also weakly stimulates the
Anastasia P Athanasoulia-Kaspar
Anastasia P Athanasoulia-Kaspar
Max Planck Institute of Psychiatry, Department of Internal Medicine, Endocrinology and Clinical Chemistry, Munich, Germany
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Kathrin H Popp
Kathrin H Popp
Max Planck Institute of Psychiatry, Department of Internal Medicine, Endocrinology and Clinical Chemistry, Munich, Germany
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Gunter Karl Stalla
Gunter Karl Stalla
Max Planck Institute of Psychiatry, Department of Internal Medicine, Endocrinology and Clinical Chemistry, Munich, Germany
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prevalence is less clearly established ( 9 ). In a prospective case-control study, the prevalence of ICDs in patients under modest doses of dopaminergic agents was as high as 17% ( 10 ). In patients with prolactinomas, these rare central side effects have
Devis Pascut
Devis Pascut
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Sofia Tamini
Sofia Tamini
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
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Silvia Bresolin
Silvia Bresolin
Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
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Pablo Giraudi
Pablo Giraudi
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Giuseppe Basso
Giuseppe Basso
Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
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Alessandro Minocci
Alessandro Minocci
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Claudio Tiribelli
Claudio Tiribelli
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Graziano Grugni
Graziano Grugni
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Alessandro Sartorio
Alessandro Sartorio
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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with obesity had already been proven ( 28 ). In particular, mir-92a-3p negatively correlated with the brown adipose tissue activity ( 29 ), while, the liver-enriched miR-122 was reported to work as central regulator of cholesterol and lipid metabolism
Katica Bajuk Studen
Katica Bajuk Studen
Nuclear Medicine Department, University Medical Centre Ljubljana, Ljubljana, Slovenia
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Marija Pfeifer
Marija Pfeifer
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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( 16 ). Metabolic syndrome Insulin resistance is a central mechanism linking together all components of the metabolic syndrome, defined by the presence of hyperglycemia (fasting glucose levels 5.6 mmol/L or above), central obesity (increased
