Anna C Simcocks
Anna C Simcocks
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
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Kayte A Jenkin
Kayte A Jenkin
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
School of Science and Health, Western Sydney University, Campbelltown, New South Wales, Australia
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School of Science and Health, Western Sydney University, Campbelltown, New South Wales, Australia
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Lannie O’Keefe
Lannie O’Keefe
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
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Chrishan S Samuel
Chrishan S Samuel
Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, Clayton, Victoria, Australia
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Michael L Mathai
Michael L Mathai
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Victoria, Australia
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The Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Victoria, Australia
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Andrew J McAinch
Andrew J McAinch
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
Australian Institute for Musculoskeletal Science (AIMSS), College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia
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Australian Institute for Musculoskeletal Science (AIMSS), College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia
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Deanne H Hryciw
Deanne H Hryciw
Institute for Health and Sport, Victoria University, St Albans campus, Melbourne, Victoria, Australia
School of Environment and Sciences, Griffith University, Nathan, Queensland, Australia
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School of Environment and Sciences, Griffith University, Nathan, Queensland, Australia
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percentage, while brown adipose tissue (BAT) depots were not altered by treatment with this compound. There was also an increase in kidney and liver mass in the DIO + O-1602-treated group while heart mass was unaffected by the chronic treatment ( Table 4
Stine Linding Andersen
Stine Linding Andersen
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Louise Knøsgaard
Louise Knøsgaard
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Aase Handberg
Aase Handberg
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Peter Vestergaard
Peter Vestergaard
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Stig Andersen
Stig Andersen
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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deiodinases may influence the levels of thyroid hormones ( 9 ). Adiposity and smoking are some of the major threats to public health and common patient characteristics in pregnant and non-pregnant women ( 10 , 11 ). In non-pregnant individuals, a higher
Signe Frøssing
Signe Frøssing
Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Malin Nylander
Malin Nylander
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Caroline Kistorp
Caroline Kistorp
Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Sven O Skouby
Sven O Skouby
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark
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Jens Faber
Jens Faber
Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
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Achieva 3.0 T MR-imaging system (Philips Medical Systems), and volumes of visceral and subcutaneous adipose tissue were measured in a 1-cm thick section at the L3 level. The CONSORT statement for reporting clinical studies was used as a guidance for the
Trevor Lewis
Trevor Lewis
Physiotherapy Department, Aintree University Hospital NHS Foundation Trust, Liverpool, UK
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Eva Zeisig
Eva Zeisig
Department of Surgical and Perioperative Sciences, Umeå Univerisity, Umeå, Sweden
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Jamie E Gaida
Jamie E Gaida
University of Canberra Research Institute for Sport and Exercise (UCRISE), Canberra, Australian Capital Territory, Australia
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exposure causes body-wide insulin resistance, the effect is tissue dependent and adipose tissue insulin sensitivity actually increases, which contributes to adipocyte differentiation and lipid accumulation ( 20 ). Similarly, glucocorticoid exposure
Emmely M de Vries
Emmely M de Vries
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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Hermina C van Beeren
Hermina C van Beeren
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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Albert C W A van Wijk
Albert C W A van Wijk
Department of Experimental Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Andries Kalsbeek
Andries Kalsbeek
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Johannes A Romijn
Johannes A Romijn
Department of Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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.1.79 ) 11 Williams CM Ellis R . Thermogenic and metabolic consequences of thyroid hormone treatment in brown and white adipose tissue . Bioscience Reports 1985 5 175 – 184 . ( https://doi.org/10.1007/BF01117064 ) 12 Obregon MJ . Thyroid
Helle Keinicke
Helle Keinicke
Insulin and Device Trial Operations, Novo Nordisk A/S, Søborg, Denmark
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Gao Sun
Gao Sun
Pharmacology and Histopathology, Novo Nordisk A/S, China
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Caroline M Junker Mentzel
Caroline M Junker Mentzel
Department of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
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Merete Fredholm
Merete Fredholm
Department of Veterinary Clinical and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark
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Linu Mary John
Linu Mary John
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Birgitte Andersen
Birgitte Andersen
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Kirsten Raun
Kirsten Raun
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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Marina Kjaergaard
Marina Kjaergaard
Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
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production may supply the brown adipose tissue (BAT) with fuel, secondary to increases in EE expenditure ( 48 , 49 ). Villarroya and colleagues have previously demonstrated that FGF21 stimulate the glucose uptake in BAT and specifically induce the glucose
Angelica Amorim Amato
Angelica Amorim Amato
Department of Pharmaceutical Sciences, University of Brasilia, Brasilia, Brazil
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Hailey Brit Wheeler
Hailey Brit Wheeler
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Bruce Blumberg
Bruce Blumberg
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA
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Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA
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) Dichlorodiphenyltrichloroethane (DDT) Pesticide Currently unknown Impairs thermogenesis in brown adipose tissue (BAT), promotes diet induced insulin resistance, promotes transgenerational inheritance of obesity (98, 100, 143) di-2-ethylhexyl (DEHP) Phthalates
Chunliang Yang
Chunliang Yang
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Junyi Li
Junyi Li
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Fei Sun
Fei Sun
The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Haifeng Zhou
Haifeng Zhou
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jia Yang
Jia Yang
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Chao Yang
Chao Yang
Department of Gerontology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, China
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islet β cells or a decline of insulin sensitivity in downstream organs, including liver, skeletal muscle and adipose tissue. Hyperglycemia can also result from inappropriately high endogenous glucose production either via glycogenolysis or
Yu Lin
Yu Lin
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Yingying Zhang
Yingying Zhang
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Lei Xu
Lei Xu
Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China
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Wei Long
Wei Long
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Chunjian Shan
Chunjian Shan
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Hongjuan Ding
Hongjuan Ding
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Lianghui You
Lianghui You
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Chun Zhao
Chun Zhao
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Zhonghua Shi
Zhonghua Shi
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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brown adipose tissue thermogenesis through the p38 MAPK pathway. Recently, Sun et al. ( 6 )identified 175 lncRNAs that are specifically regulated during adipogenesis. These lncRNAs were shown to be strongly involved in adipogenesis under the control of
Linfei Yang
Linfei Yang
Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, China
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Xiao Yu
Xiao Yu
Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Yongchao Yang
Yongchao Yang
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression. FASEB Journal 2015 29 3990 – 4000 . ( https://doi.org/10.1096/fj.15-274480 ) 29 Bosman F Carneiro F Hruban R Theise N , et al
