Department of Pediatrics, Navarra Hospital Complex, Pamplona, Spain
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by Teodoro Durá-Travé in
Google Scholar
PubMed
Search for other papers by Fidel Gallinas-Victoriano in
Google Scholar
PubMed
Search for other papers by María Malumbres-Chacon in
Google Scholar
PubMed
Search for other papers by Lotfi Ahmed-Mohamed in
Google Scholar
PubMed
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by María Jesús Chueca -Guindulain in
Google Scholar
PubMed
Navarra Institute for Health Research (IdisNA), Pamplona, Spain
Search for other papers by Sara Berrade-Zubiri in
Google Scholar
PubMed
Introduction Central precocious puberty (CPP) is defined as the premature activation of the hypothalamic–pituitary–gonadal axis (HPG) with the onset of breast development before 8 years of age in girls and an increase in testicular size in
Armed Forces College of Medicine, Cairo, Egypt
Search for other papers by Wafaa M Rashed in
Google Scholar
PubMed
Search for other papers by Anas Saad in
Google Scholar
PubMed
Search for other papers by Muneer Al-Husseini in
Google Scholar
PubMed
Search for other papers by Ahmed Mahmoud Galal in
Google Scholar
PubMed
Search for other papers by Assem Mohamed Ismael in
Google Scholar
PubMed
Search for other papers by Ahmed M Al-Tayep in
Google Scholar
PubMed
Search for other papers by Ayman El Shafie in
Google Scholar
PubMed
Search for other papers by Mahmoud Ahmed Ali in
Google Scholar
PubMed
Search for other papers by Ahmad Samir Alfaar in
Google Scholar
PubMed
adrenal gland tumors as second primary cancers (clear cell adenocarcinoma, NOS (8310/3) and renal cell carcinoma (8312/3)). Both female breast (27 cases, 23.1%) and prostate (22 cases, 18.8%) were the most frequent primary cancer sites that preceded an
Disciplina de Endocrinologia, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, São Paulo, Brazil
Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular LIM/42, Disciplina de Endocrinologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil
Search for other papers by Renata C Scalco in
Google Scholar
PubMed
Search for other papers by Ericka B Trarbach in
Google Scholar
PubMed
Search for other papers by Edoarda V A Albuquerque in
Google Scholar
PubMed
Search for other papers by Thais K Homma in
Google Scholar
PubMed
Search for other papers by Thais H Inoue-Lima in
Google Scholar
PubMed
Search for other papers by Mirian Y Nishi in
Google Scholar
PubMed
Search for other papers by Berenice B Mendonca in
Google Scholar
PubMed
Search for other papers by Alexander A L Jorge in
Google Scholar
PubMed
( ESR1 ) participate in the variability of many characteristics, such as height, bone density, breast size and risk of cancer ( 8 , 9 , 10 , 11 ). There is only one study involving TS patients that showed an association between two ESR1
Université Côte d'Azur, INSERM, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Nice, France
Search for other papers by Hichem Bouguerra in
Google Scholar
PubMed
Search for other papers by Gorrab Amal in
Google Scholar
PubMed
Search for other papers by Stephan Clavel in
Google Scholar
PubMed
Search for other papers by Hamouda Boussen in
Google Scholar
PubMed
Search for other papers by Jean-François Louet in
Google Scholar
PubMed
Search for other papers by Asma Gati in
Google Scholar
PubMed
including breast cancer (BC) ( 1 , 2 , 3 ). Obese BC patients exhibit a higher risk for lymph node metastasis, aggressive tumor, and mortality when compared with non-obese BC patients. Yet, the cellular and molecular mechanisms underlying this association
Search for other papers by M Krause in
Google Scholar
PubMed
Search for other papers by H Frederiksen in
Google Scholar
PubMed
Search for other papers by K Sundberg in
Google Scholar
PubMed
Search for other papers by F S Jørgensen in
Google Scholar
PubMed
Search for other papers by L N Jensen in
Google Scholar
PubMed
Search for other papers by P Nørgaard in
Google Scholar
PubMed
Search for other papers by C Jørgensen in
Google Scholar
PubMed
Search for other papers by P Ertberg in
Google Scholar
PubMed
Section of Biostatistics, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
Search for other papers by J H Petersen in
Google Scholar
PubMed
Search for other papers by U Feldt-Rasmussen in
Google Scholar
PubMed
Search for other papers by A Juul in
Google Scholar
PubMed
Search for other papers by K T Drzewiecki in
Google Scholar
PubMed
Search for other papers by N E Skakkebaek in
Google Scholar
PubMed
Search for other papers by A M Andersson in
Google Scholar
PubMed
Background
Several chemical UV filters/absorbers ('UV filters' hereafter) have endocrine-disrupting properties in vitro and in vivo. Exposure to these chemicals, especially during prenatal development, is of concern.
Objectives
To examine maternal exposure to UV filters, associations with maternal thyroid hormone, with growth factor concentrations as well as to birth outcomes.
Methods
Prospective study of 183 pregnant women with 2nd trimester serum and urine samples available. Maternal concentrations of the chemical UV filters benzophenone-1 (BP-1) and benzophenone-3 (BP-3) in urine and 4-hydroxy-benzophenone (4-HBP) in serum were measured by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The relationships between 2nd trimester maternal concentrations of the three chemical UV filters and maternal serum concentrations of thyroid hormones and growth factors, as well as birth outcomes (weight, height, and head and abdominal circumferences) were examined.
Results
Positive associations between maternal serum concentrations of 4-HBP and triiodothyronine (T3), thyroxine (T4), insulin-like growth factor I (IGF-I) and its binding protein IGFBP3 were observed in mothers carrying male fetuses. Male infants of mothers in the middle 4-HBP exposure group had statistically significantly lower weight and shorter head and abdominal circumferences at birth compared to the low exposure group.
Conclusions
Widespread exposure of pregnant women to chemical UV filters and the possible impact on maternal thyroid hormones and growth factors, and on fetal growth, calls for further studies on possible long-term consequences of the exposure to UV filters on fetal development and children’s health.
Search for other papers by Kristin Godang in
Google Scholar
PubMed
Search for other papers by Karolina Lundstam in
Google Scholar
PubMed
Search for other papers by Charlotte Mollerup in
Google Scholar
PubMed
Search for other papers by Stine Lyngvi Fougner in
Google Scholar
PubMed
Search for other papers by Ylva Pernow in
Google Scholar
PubMed
Search for other papers by Jörgen Nordenström in
Google Scholar
PubMed
Search for other papers by Thord Rosén in
Google Scholar
PubMed
Search for other papers by Svante Jansson in
Google Scholar
PubMed
Search for other papers by Mikael Hellström in
Google Scholar
PubMed
Faculty of Medicine, University of Oslo, Oslo, Norway
Search for other papers by Jens Bollerslev in
Google Scholar
PubMed
Faculty of Medicine, University of Oslo, Oslo, Norway
Search for other papers by Ansgar Heck in
Google Scholar
PubMed
Search for other papers by the SIPH Study Group in
Google Scholar
PubMed
Context
Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors.
Objective
To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism.
Design, patients, interventions, main outcome measures
119 patients previously randomized to observation (OBS; n = 58) or parathyroidectomy (PTX; n = 61) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter study, were included. Main outcome measures for this study were the differences in fat mass, markers for lipid and glucose metabolism between OBS and PTX 5 years after randomization.
Results
In the OBS group, total cholesterol (Total-C) decreased from mean 5.9 (±1.1) to 5.6 (±1.0) mmol/L (P = 0.037) and LDL cholesterol (LDL-C) decreased from 3.7 (±1.0) to 3.3 (±0.9) mmol/L (P = 0.010). In the PTX group, the Total-C and LDL-C remained unchanged resulting in a significant between-group difference over time (P = 0.013 and P = 0.026, respectively). This difference was driven by patients who started with lipid-lowering medication during the study period (OBS: 5; PTX: 1). There was an increase in trunk fat mass in the OBS group, but no between-group differences over time. Mean 25(OH) vitamin D increased in the PTX group (P < 0.001), but did not change in the OBS group. No difference in parameters of glucose metabolism was detected.
Conclusion
In mild PHPT, the measured metabolic and cardiovascular risk factors were not modified by PTX. Observation seems safe and cardiovascular risk reduction should not be regarded as a separate indication for parathyroidectomy based on the results from this study.
Search for other papers by Panagiotis Anagnostis in
Google Scholar
PubMed
Search for other papers by Irene Lambrinoudaki in
Google Scholar
PubMed
Search for other papers by John C Stevenson in
Google Scholar
PubMed
Search for other papers by Dimitrios G Goulis in
Google Scholar
PubMed
controlled trial setting (RCTs). The hallmark RCT, designed to investigate the effect of MHT on CVD (with CHD as the main outcome) and breast cancer risk, was the Women’s Health Initiative (WHI) Study. This study had two arms; the first (WHI-1) compared the
Department of Clinical Sciences and Community Health, Università degli Studi, Milan, Italy
Search for other papers by Elena Galazzi in
Google Scholar
PubMed
Search for other papers by Paolo Duminuco in
Google Scholar
PubMed
Search for other papers by Mirella Moro in
Google Scholar
PubMed
Search for other papers by Fabiana Guizzardi in
Google Scholar
PubMed
Search for other papers by Nicoletta Marazzi in
Google Scholar
PubMed
Division of Auxology and Metabolic Diseases, IRCSS Istituto Auxologico Italiano, Piancavallo (VB), Italy
Search for other papers by Alessandro Sartorio in
Google Scholar
PubMed
Search for other papers by Sabrina Avignone in
Google Scholar
PubMed
Department of Clinical Sciences and Community Health, Università degli Studi, Milan, Italy
Search for other papers by Marco Bonomi in
Google Scholar
PubMed
Department of Clinical Sciences and Community Health, Università degli Studi, Milan, Italy
Search for other papers by Luca Persani in
Google Scholar
PubMed
Search for other papers by Maria Teresa Bonati in
Google Scholar
PubMed
-ventral limb axis. The same inductive interaction between epithelial tissue and underlying mesenchyme demonstrated for limb buds had been found in breast, tooth and genital development ( 1 ). Recently, it has also been reported that Tbx3 functionality is
Search for other papers by Masatada Watanabe in
Google Scholar
PubMed
Search for other papers by Shuji Ohno in
Google Scholar
PubMed
Search for other papers by Hiroshi Wachi in
Google Scholar
PubMed
.g. exemestane) employed as part of breast cancer therapy cause vasculitis in skin tissues with cutaneous eruptions and palpable purpura as side effects ( 4 ). These reports suggest that sex steroids, especially estrogen, are important for the maintenance of skin
Search for other papers by Mei Li in
Google Scholar
PubMed
Search for other papers by Yanfei Chen in
Google Scholar
PubMed
Search for other papers by Binrong Liao in
Google Scholar
PubMed
Search for other papers by Jing Tang in
Google Scholar
PubMed
Search for other papers by Jingzi Zhong in
Google Scholar
PubMed
Search for other papers by Dan Lan in
Google Scholar
PubMed
). The serum levels of kisspeptin in precocious puberty are inconsistent and this includes cases of premature thelarche (PT), which is defined as isolated budding of the breast in girls before 8 without other pubertal features. Additionally, there are
