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Stan Ursem, Vito Francic, Martin Keppel, Verena Schwetz, Christian Trummer, Marlene Pandis, Felix Aberer, Martin R Grübler, Nicolas D Verheyen, Winfried März, Andreas Tomaschitz, Stefan Pilz, Barbara Obermayer-Pietsch and Annemieke C Heijboer

Introduction Parathyroid hormone (PTH) plays a critical role in maintaining adequate serum calcium homeostasis. It increases serum calcium by stimulating bone resorption, promoting phosphate excretion, converting vitamin D to its active form

Open access

Earn H Gan, Wendy Robson, Peter Murphy, Robert Pickard, Simon Pearce and Rachel Oldershaw

cell field, owing to their multipotent differentiation capacity, low tumorigenicity and tolerogenic nature for allogenic cell-based therapies. They were initially isolated from the adult bone marrow and have subsequently been harvested from several

Open access

Agnieszka Pazderska, Yaasir Mamoojee, Satish Artham, Margaret Miller, Stephen G Ball, Tim Cheetham and Richard Quinton

interquartile ranges. Pre- and post-treatment parameters were compared using the Mann–Whitney U -test. Results Longitudinal data detailing pubertal staging, laboratory parameters and bone mineral density are shown in Table 2 . All patients completed

Open access

Cristina Lamas, Elena Navarro, Anna Casterás, Paloma Portillo, Victoria Alcázar, María Calatayud, Cristina Álvarez-Escolá, Julia Sastre, Evangelina Boix, Lluis Forga, Almudena Vicente, Josep Oriola, Jordi Mesa and Nuria Valdés

manifestation: most carriers of a MEN1 mutation will have developed PHPT by age 50 years. It is also the first clinical manifestation, usually diagnosed before 30 years of age, and bone and renal complications are common. However, not many clinical studies

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A Gizard, A Rothenbuhler, Z Pejin, G Finidori, C Glorion, B de Billy, A Linglart and P Wicart

). The PHEX protein is expressed in the mineralized tissues, i.e. the bone matrix and the teeth. When PHEX is impaired, fibroblast growth factor 23 (FGF23) is produced in excess, leading to renal phosphate wasting and insufficient production of 1,25(OH)2

Open access

Xi Wang and Qi Yu

/1,000,000 ( 1 , 2 ). MAS is defined historically as the triad of peripheral precocious puberty (PP), café-au-lait skin pigmentation and fibrous dysplasia (FD) of the bone ( 3 ). Other associated hyperfunctioning endocrinopathies include hyperthyroidism, growth

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Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan and Anil Bhansali

acquaintance with Jamer's dynamometer and an average of three measurements was taken as the final reading as kilogram force. Bone mineral content (BMC), bone mineral density (BMD), total body fat (TBF), and lean body mass (LBM) were calculated by dual-energy X

Open access

Mieke Van Hemelrijck, Thurkaa Shanmugalingam, Cecilia Bosco, Wahyu Wulaningsih and Sabine Rohrmann

bone resorption and bone formation (11) , thus also suggesting a potential interaction between calcium and IGF1 in terms of bone metabolism (11) . Circulating levels of IGF1 have been associated with milk and calcium intake (6, 12, 13) . For instance

Open access

Vickie Braithwaite, Kerry S Jones, Shima Assar, Inez Schoenmakers and Ann Prentice

community (2) . FGF23 is a bone-derived phosphate (P)-regulating hormone that acts primarily in the proximal tubule cells of the kidney. A raised FGF23 concentration is a predictor of mortality in patients with renal failure (3) . FGF23 together with its

Open access

Rui-yi Tang, Rong Chen, Miao Ma, Shou-qing Lin, Yi-wen Zhang and Ya-ping Wang

). Cases of KS account for approximately 40–60% of all IHH cases ( 3 , 4 ). IHH negatively affects patients’ sexual, bone and metabolic health, as well as their psychological development ( 5 , 6 ). Thus, a precise early diagnosis and timely treatment