Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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-pituitary-adrenal (HPA) axis, the influence of the master clock is exerted by canonical endocrine signalling via arginine vasopressin (AVP) modification of pulsatile ACTH secretion, but there also exist non-endocrine pathways with neural signalling via the splanchnic
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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-releasing hormone and arginine vasopressin. These factors cause secretion of adrenocorticotropic hormone in the anterior pituitary, which is released into the systemic circulation causing synthesis and secretion of GCs by the adrenal cortex (11, 12) . The
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liver may be responsible for the compensatory activation of the HPA axis. Women with abdominal obesity phenotype have an exaggerated ACTH and cortisol response to combined CRH/AVP (corticotropin-releasing hormone/arginine vasopressin) stimulation ( 40
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(PVN) secrete corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) ( 1 ) into the hypophyseal portal circulation, and these act on anterior pituitary corticotroph cells to trigger secretion of adrenocorticotropic hormone (ACTH) ( 2 , 3