Charlotte Höybye
Charlotte Höybye
Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital and Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
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Andreas F H Pfeiffer
Andreas F H Pfeiffer
Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Klinik für Endokrinologie & Stoffwechselmedizin, Berlin, Germany
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Diego Ferone
Diego Ferone
IRCCS AOU San Martino-IST, Università di Genova – Endocrinologia DiMI, Dipartimento di Medicina Interna e Specialità Mediche, & CEBR, Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy
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Jens Sandahl Christiansen
Jens Sandahl Christiansen
Medicinsk Endokrinologist Afd., MEA, NBG, Århus Sygehus, Århus, Denmark
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David Gilfoyle
David Gilfoyle
Ascendis Pharma A/S, Hellerup, Denmark
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Eva Dam Christoffersen
Eva Dam Christoffersen
Ascendis Pharma A/S, Hellerup, Denmark
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Eva Mortensen
Eva Mortensen
Ascendis Pharma Inc., Palo Alto, California, USA
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Jonathan A Leff
Jonathan A Leff
Ascendis Pharma Inc., Palo Alto, California, USA
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Michael Beckert
Michael Beckert
Ascendis Pharma A/S, Hellerup, Denmark
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reactions (defined as erythema, swelling and pain) at 8, 12 and 24 h after dose on Days 8 and 15 as well as by patient diary. Blood samples for PK and PD assessments in the TransCon GH cohorts were collected at Day 0 and pre-dose on Days 1, 8, 15 and 22
Kazhan Mollazadegan
Kazhan Mollazadegan
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Britt Skogseid
Britt Skogseid
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Johan Botling
Johan Botling
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
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Tobias Åkerström
Tobias Åkerström
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Barbro Eriksson
Barbro Eriksson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Staffan Welin
Staffan Welin
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Anders Sundin
Anders Sundin
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Joakim Crona
Joakim Crona
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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grading of panNENs ( 3 ), high-grade neoplasms were separated into two categories: well-differentiated (WD) pancreatic neuroendocrine tumor grade 3 (panNET-G3) and poorly differentiated (PD) NEC ( 4 ). PanNET-G3 frequently harbors mutations in MEN1 and
M I Stamou
M I Stamou
Harvard Reproductive Sciences Center, Massachusetts General Hospital, Boston, Massachusetts, USA
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
Mount Auburn Hospital, Harvard Medical School Teaching Hospital, Cambridge, Massachusetts, USA
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Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
Mount Auburn Hospital, Harvard Medical School Teaching Hospital, Cambridge, Massachusetts, USA
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P Varnavas
P Varnavas
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
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L Plummer
L Plummer
Harvard Reproductive Sciences Center, Massachusetts General Hospital, Boston, Massachusetts, USA
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V Koika
V Koika
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
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N A Georgopoulos
N A Georgopoulos
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
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effect PP Pathogenicity MAF in ExAC browse non-Finnish Europeans No of probands Dx CHD7 c.8962 8963insG p.D2988GfsX2 Frameshift NA Deleterious Not seen 1 nIHH CHD7 c.5051-4C>T Splice site NA Deleterious
Rossella Cannarella
Rossella Cannarella
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Teresa Mattina
Teresa Mattina
Genetics, University of Catania, Catania, Italy
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Rosita A Condorelli
Rosita A Condorelli
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Laura M Mongioì
Laura M Mongioì
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Giuseppe Pandini
Giuseppe Pandini
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Sandro La Vignera
Sandro La Vignera
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Aldo E Calogero
Aldo E Calogero
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy
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Introduction Insulin-like growth factor 1 receptor ( IGF1R ) gene, made up of 315,991 base pairs, maps on the 15q26.3 chromosome. It encodes for a protein with a tyrosine kinase domain, which binds the IGF1 and is responsible for its
Martin Zweifel
Martin Zweifel
Department of Medical Oncology, University Hospital Bern, Bern, Switzerland
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Beat Thürlimann
Beat Thürlimann
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Salome Riniker
Salome Riniker
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Patrik Weder
Patrik Weder
Breast Centre St. Gallen, Kantonsspital St. Gallen, St. Gallen, Switzerland
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Roger von Moos
Roger von Moos
Kantonsspital Graubünden, Chur, Switzerland
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Olivia Pagani
Olivia Pagani
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
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Martin Bigler
Martin Bigler
SAKK Coordinating Centre, Bern, Switzerland
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Karin M Rothgiesser
Karin M Rothgiesser
SAKK Coordinating Centre, Bern, Switzerland
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Christiane Pilop
Christiane Pilop
SAKK Coordinating Centre, Bern, Switzerland
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Hanne Hawle
Hanne Hawle
SAKK Coordinating Centre, Bern, Switzerland
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Peter Brauchli
Peter Brauchli
SAKK Coordinating Centre, Bern, Switzerland
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Coya Tapia
Coya Tapia
Institute of Pathology, University of Bern, Bern, Switzerland
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Wolfgang Schoenfeld
Wolfgang Schoenfeld
CURADIS GmbH, Erlangen, Germany
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Cristiana Sessa
Cristiana Sessa
Istituto Oncologico della Svizzera Italiana, Bellinzona, Switzerland
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for the Swiss Group for Clinical Cancer Research (SAKK)
for the Swiss Group for Clinical Cancer Research (SAKK)
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included as an additional secondary endpoint later on. Pharmacokinetics (PK) and pharmacodynamics (PD) Plasma and serum 4-OHT, 4-OHA (for PK) and oestradiol (for PD) concentrations were measured at baseline, after single dose administration at 1, 2
Paweł Komarnicki
Paweł Komarnicki
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Paweł Gut
Paweł Gut
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Jan Musiałkiewicz
Jan Musiałkiewicz
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Maja Cieślewicz
Maja Cieślewicz
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Adam Maciejewski
Adam Maciejewski
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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Prachi Patel
Prachi Patel
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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George Mastorakos
George Mastorakos
Unit of Endocrinology, Diabetes Mellitus and Metabolism, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Marek Ruchała
Marek Ruchała
Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland
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%) G2 22 (54%) Treatment response sd 20 (49%) pd 21 (51%) Ki 67 1% 2 (5%) 2% 17 (41%) 4% 2 (5%) 5% 8 (20%) 10% 12 (29%) * Mean ( s.d. ). LTB was
Wei Li
Wei Li
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China
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Qing Huang
Qing Huang
Collage of Tourism and Service Management, Nankai University, Tianjin, People’s Republic of China
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Danyang Sun
Danyang Sun
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China
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Guizhi Zhang
Guizhi Zhang
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China
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Jian Tan
Jian Tan
Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China
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particles and technical assistance. References 1 Chen W Zheng R Baade PD Zhang S Zeng H Bray F Jemal A Yu XQ He J . Cancer statistics in China, 2015 . CA: A Cancer Journal for Clinicians 2016 66 115 – 132
Unni Syversen
Unni Syversen
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Department of Endocrinology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Department of Endocrinology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Mats Peder Mosti
Mats Peder Mosti
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Ida Maria Mynarek
Ida Maria Mynarek
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
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Trude Seselie Jahr Vedal
Trude Seselie Jahr Vedal
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
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Kristin Aasarød
Kristin Aasarød
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Department of Gastroenterology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Department of Gastroenterology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Trude Basso
Trude Basso
Department of Orthopedics, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Janne E Reseland
Janne E Reseland
Department of Biomaterials, University of Oslo, Oslo, Norway
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Per Medbøe Thorsby
Per Medbøe Thorsby
Hormone Laboratory, Department of Medical Biochemistry, Oslo University Hospital, Aker, Oslo, Norway
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Bjorn O Asvold
Bjorn O Asvold
Department of Endocrinology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Trondheim, Norway
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K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Trondheim, Norway
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Erik Fink Eriksen
Erik Fink Eriksen
Department of Biomaterials, University of Oslo, Oslo, Norway
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Astrid Kamilla Stunes
Astrid Kamilla Stunes
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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density and fracture risk in patients with type 1 and type 2 diabetes: a meta-analysis . Osteoporosis International 2007 18 427 – 444 . ( https://doi.org/10.1007/s00198-006-0253-4 ) 5 Chavassieux P Seeman E Delmas PD . Insights into
B C M Hermans
B C M Hermans
Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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J L Derks
J L Derks
Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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H J M Groen
H J M Groen
Department of Pulmonary Diseases, University of Groningen and University Medical Centre, Groningen, The Netherlands
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J A Stigt
J A Stigt
Department of Pulmonary Diseases, Isala Hospital, Zwolle, The Netherlands
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R J van Suylen
R J van Suylen
Pathology-DNA, Jeroen Bosch Hospital, ‘s Hertogenbosch, The Netherlands
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L M Hillen
L M Hillen
Department of Pathology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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E C van den Broek
E C van den Broek
PALGA Foundation, Utrecht, The Netherlands
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E J M Speel
E J M Speel
Department of Pathology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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A-M C Dingemans
A-M C Dingemans
Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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Thorax, adrenal gland, liver Eto-carbo 12 D Male 49 N/a 1 0 Lobectomy + metastasectomy + WBRT 12 At least brain Resection 18 E Male 55 >40 1a 0 Lobectomy + metastasectomy + chemotherapy (cis-pem, PD) 4
Hélène Singeisen
Hélène Singeisen
Department of Internal Medicine, Endocrinology, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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Mariko Melanie Renzulli
Mariko Melanie Renzulli
Institute of Radiology, Cantonal Hospital Thurgau, Frauenfeld, Switzerland
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Vojtech Pavlicek
Vojtech Pavlicek
Department of Internal Medicine, Endocrinology, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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Pascal Probst
Pascal Probst
Department of Surgery, Cantonal Hospital Thurgau, Frauenfeld, Switzerland
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Fabian Hauswirth
Fabian Hauswirth
Department of Surgery, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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Markus K Muller
Markus K Muller
Department of Surgery, Cantonal Hospital Thurgau, Frauenfeld, Switzerland
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Magdalene Adamczyk
Magdalene Adamczyk
Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
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Achim Weber
Achim Weber
Department of Pathology and Molecular Pathology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
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Reto Martin Kaderli
Reto Martin Kaderli
Department of Visceral Surgery and Medicine, Bern University Hospital, University of Bern, Bern, Switzerland
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Pietro Renzulli
Pietro Renzulli
Department of Surgery, Cantonal Hospital Thurgau, Münsterlingen, Switzerland
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Introduction Multiple endocrine neoplasia (MEN) is a rare group of autosomal dominant disorders with a wide spectrum of endocrine and non-endocrine manifestations ( Table 1 ). Five different types of MEN have been described so far: MEN1, MEN2
