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Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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-hydroxyprogesterone, DHEA and progesterone. Inter-laboratory quality and accuracy of sample analysis was assessed prior to the study with the Mayo Clinic (NMS Labs, Rochester, MN) and Children’s National Medical Center (Washington, DC). Statistical analysis
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samples were frozen and stored at −70°C. Laboratory procedures Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E 2 ), total testosterone, free testosterone, androstendione, DHEA-S and SHBG were
Tropical Institute of Reproductive Medicine, Cuiabá, Mato Grosso, Brazil
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reduction in DHEAS after the 20s in normal ovulatory women ( 10 , 17 , 18 , 19 , 24 , 49 , 70 , 71 , 75 , 76 ). A decline of 18 to 36% in DHEAS in PCOS women, between the ages of 20 years and 45 years, have been reported ( 4 , 5 , 77 ), giving
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INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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Département d'Endocrinologie et de Gynécologie Pédiatrique, Hôpital Arnaud de Villeneuve, Université de Montpellier, Montpellier, France
INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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of testosterone and gonadotropins in plasma. Moreover, quantification of plasma 17-hydroxyprogesterone, and possibly of other androgens (e.g. delta-4 androstenedione (A4) and dehydroepiandrosterone sulfate (DHEA-S)), and abdominopelvic ultrasonography
University of Alcalá, Madrid, Spain
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patients underwent at least one DST. At the discretion of the patient’s physician, the study was completed by measuring urinary cortisol levels, adrenocorticotropic hormone (ACTH), dehydroepiandrosterone sulfate (DHEA-S) and night-time salivary cortisol. In
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
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INSERM UMR_S933, Paris, France
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Université Pierre et Marie Curie, Sorbonne Université, Paris, France
INSERM UMR_S933, Paris, France
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precursors such as DHEA-S leading to testosterone biosynthesis via peripheral non-mutated HSD3B1 and HSD17B5 activity ( Fig. 1 ). Some patients in the literature have been treated with intra-muscular testosterone injections. The main goal of this
Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.
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4 ) S3 – S5 . ( https://doi.org/10.1016/s0015-0282(02)02985-0 ) 37 Labrie F Martel C Belanger A Pelletier G . Androgens in women are essentially made from DHEA in each peripheral tissue according to intracrinology . Journal of Steroid
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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of de novo androgen synthesis, while the postmenopausal ovary depends on adrenal DHEA/S as the substrate to produce testosterone and androstenedione. This would explain the low androgen levels found in postmenopausal women with AD. Moreover, this
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
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University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
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University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
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). Androstenedione and DHEAS were measured by specific double antibody RIA using 125 I-labeled hormones (Diagnostic Systems Laboratories, Webster, Tx). Total and free testosterone levels were measured by coated tube RIA (DiaSorin, S. p. A, Salluggia, Italy and
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Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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RBP4 were analysed by enzyme-linked immunosorbent assay according to the manufacturer’s instructions (Quantikine ELISA; R&D Systems). The intra- and inter-assay coefficients of variation were 6.5 and 9% respectively. The metabolic variables