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Andrea V Haas Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Paul N Hopkins Cardiovascular Genetics, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA

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Nancy J Brown Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Luminita H Pojoga Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Jonathan S Williams Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Gail K Adler Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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Gordon H Williams Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

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the high-mode cortisol group, whose risk was 6% ( 18 ). Those in the high-mode cortisol group and CAV1 risk allele carriers had a 2- to 2.5-fold higher 10-year CV risk (8%) compared to those in the low-mode cortisol group and non-risk allele carriers

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0182
Volume/Issue:
Volume 8: Issue 6
Open access
Mojca Jensterle Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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Nika Aleksandra Kravos Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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Simona Ferjan Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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Katja Goricar University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Ljubljana, Slovenia

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Vita Dolzan University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Ljubljana, Slovenia

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Andrej Janez Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia
University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia

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.2–24.3%. Intra-assay CV for SHBG is 2.5–5.3% and inter-assay CV is 4–6.6%. BMI was calculated as the weight in kilograms divided by square of height in meters. Menstrual regularity was defined as number of bleeds per year using self reported menstrual intervals

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0449
Volume/Issue:
Volume 9: Issue 1
Open access
Yuan Fang Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

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Xuehong Zhang Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA

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Huilin Xu Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Stephanie A Smith-Warner Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

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Dongli Xu Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Hong Fang Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Wang Hong Xu Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

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reducing endogenous reactive oxygen species production and associated DNA damage and mutations ( 5 ). Recently, the excess risk of cancer observed in individuals with T2DM has been considered to be inflated by reporting bias ( 6 ), detection bias ( 7 ) or

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0381
Volume/Issue:
Volume 7: Issue 12
Open access
Anne M Drewes University of Aarhus, Aarhus C, Denmark

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Maria E Møller The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark

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Rasmus Hertzum-Larsen The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark

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Gerda Engholm The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark

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Hans H Storm The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark

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50). The incidence was 4.897 new cases per year between 2009 and 2013, and the number has been increasing over the last five decades ( Fig. 1 ) ( 5 ). The aetiology of breast cancer is multifactorial and may involve interaction between environmental

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0498
Volume/Issue:
Volume 9: Issue 1
Open access
Agnieszka Pazderska Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
Department of Endocrinology, St James’s Hospital, Dublin, Ireland

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Yaasir Mamoojee Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK

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Satish Artham Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK

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Margaret Miller Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK

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Stephen G Ball Department of Endocrinology, Central Manchester University Hospitals, Manchester, UK
Department of Endocrinology, University of Manchester, Manchester, UK

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Tim Cheetham Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle upon Tyne, UK
Department of Paediatric Endocrinology & Diabetes, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK

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Richard Quinton Department of Endocrinology, Newcastle-upon-Tyne Hospitals, Newcastle upon Tyne, UK
Endocrine Research Group, Institute of Genetic Medicine, University of Newcastle-upon-Tyne, Newcastle upon Tyne, UK

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presented with life-changing injuries resulting from major self-harm episode influenced by low self-esteem. Median age at treatment initiation was 56 years (range 38.4–69.5). Treatment over the first year was with IM Sustanon 250 mg administered monthly

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0241
Volume/Issue:
Volume 7: Issue 1
Open access
Shenglong Le Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland

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Leiting Xu Medical School, Ningbo University, Ningbo, China

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Moritz Schumann Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, Germany
The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China

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Na Wu Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland

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Timo Törmäkangas Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland

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Markku Alén Department of Medical Rehabilitation, Oulu University Hospital, Oulu, Finland

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Sulin Cheng Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China

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Petri Wiklund Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Department of Epidemiology and Biostatistics, Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland

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at the 7.5-year follow-up assessments, respectively. The age at menarche was defined as the first onset of menstrual bleeding reported by questionnaire or phone call during the follow-up. Time relative to menarche (TRM, in months) was defined as the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0044
Volume/Issue:
Volume 8: Issue 5
Open access
Keiko Ohkuwa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Mitsuji Nagahama Department of Surgery, Ito Hospital, Tokyo, Japan

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Wataru Kitagawa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kenichi Matsuzu Department of Surgery, Ito Hospital, Tokyo, Japan

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Akifumi Suzuki Department of Surgery, Ito Hospital, Tokyo, Japan

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Chisato Tomoda Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiyomi Hames Department of Surgery, Ito Hospital, Tokyo, Japan

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Junko Akaishi Department of Surgery, Ito Hospital, Tokyo, Japan

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Chie Masaki Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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the start of RAI treatment, and higher NLR. As depicted in Fig. 4 , the 5-, 10-, and 15-year survival rates after metastasis detection in the high-risk group were 69.5, 59.7, and 19.9%, respectively, which were much worse than those in the low- and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0215
Volume/Issue:
Volume 10: Issue 8
Open access
Nella Augusta Greggio Endocrinology and Adolescence Unit, Department of Woman and Child Health, University of Padova, Padova, Italy

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Elisa Rossi CINECA – Interuniversity Consortium (Health Service), Bologna, Italy

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Silvia Calabria CORE srl – Collaborative Outcome Research, Bologna, Italy

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Alice Meneghin Endocrinology and Adolescence Unit, Department of Woman and Child Health, University of Padova, Padova, Italy

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Joaquin Gutierrez de Rubalcava Endocrinology and Adolescence Unit, Department of Woman and Child Health, University of Padova, Padova, Italy

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Carlo Piccinni CORE srl – Collaborative Outcome Research, Bologna, Italy

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Antonella Pedrini CORE srl – Collaborative Outcome Research, Bologna, Italy

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TSH (4.5–10 µU/mL) and those with a mild increase of TSH (>10 µU/mL). The risk of SH progression to overt hypothyroidism is less common in paediatric population and adolescents than that in adults (<1–20%) ( 4 , 7 ). Usually, children show a natural

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0066
Volume/Issue:
Volume 6: Issue 6
Open access
Xiaomei Zhang Department of Endocrinology, Peking University International Hospital, Beijing, China

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Zhangrong Xu Diabetes Center, Characteristic Medical Center of Strategic Support Force, Beijing, China

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Xingwu Ran Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China

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Linong Ji Department of Endocrinology, Peking University International Hospital, Beijing, China
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China

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associated with a higher risk of both cardiovascular and all-cause mortality ( 1 , 2 , 3 ). It also leads to a high rate of lower-limb adverse events and nontraumatic amputations ( 4 , 5 ). The prevalence of LEAD among diabetic patients was very high and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0152
Volume/Issue:
Volume 10: Issue 9
Open access
Thera P Links Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Trynke van der Boom Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Wouter T Zandee Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Joop D Lefrandt Division of Vascular Medicine, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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fibrillation and stroke Prospective 11303 controls Park (2018) (37) 3822 DTC patients Year and age at cancer diagnosis, sex, cancer stage, TSH suppression therapy, baseline BMI, and baseline comorbidity were risk factors for CVD Cohort

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0539
Volume/Issue:
Volume 10: Issue 1
Open access