Department of Neurosurgery, Rui-Jin Lu-Wan Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Department of Neurosurgery, Rui-Jin Lu-Wan Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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College of Information Technology and Engineering, Chengdu University, Chengdu, China
College of Computer Science, Sichuan Normal University, Chengdu, Sichuan, China
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patients were smaller than 10 mm. All CD patients were treated with transsphenoidal surgery without radiotherapy or bilateral adrenalectomy. About 8 of 60 active CD patients and 1 short-term-remitted CD patient had previously undergone surgery. One long
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, diabetes insipidus; AVP, arginine vasopressin; CP, copeptin. Out of 40 patients, 15 had pituitary disease ( n =1 sarcoidosis, n =1 Langerhans cell histiocytosis, n =1 Rathke's cleft cyst, n =7 transsphenoidal resection of a sellar tumor (either with or
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≥ 126 mg/dL, glycated haemoglobin (HbA1c) ≥ 6.5% or receiving medication for hyperglycaemia. Nine patients had undergone transsphenoidal surgery before pasireotide treatment. Most patients had been treated with first-generation SRLs and/or cabergoline
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panhypopituitarism (3 cases) and DI (3 cases). Visual symptoms were also noted in two patients. In keeping with the natural history of these lesions, several patients did not have any pituitary-related clinical manifestations. Four patients underwent transsphenoidal
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://doi.org/10.1016/j.ando.2015.04.002 ) 19 Jahangiri A Wagner JR Han SW Tran MT Miller LM Chen R Tom MW Ostling LR Kunwar S Blevins L Improved versus worsened endocrine function after transsphenoidal surgery for nonfunctional pituitary
Université Lyon 1, Villeurbanne, France
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Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Université Lyon 1, Villeurbanne, France
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INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
Service de Neurochirurgie, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron, France
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Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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Université Lyon 1, Villeurbanne, France
INSERM U1052, CNRS, UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France
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order to control cortisol excess and to prevent morbi-mortality. Transsphenoidal surgical resection is the first-line treatment with a remission rate of approximately 75% when the surgery is performed by an expert pituitary surgeon ( 6 , 7 , 8
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Neuroendocrinology Division – Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil
Endocrinology Division – Hospital Federal de Bonsucesso, Rio de Janeiro Brazil
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Neuroendocrinology Division – Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil
Neuropatology and Molecular Genetics Laboratory – Instituto Estadual do Cérebro Paulo Niemeyer, Rio de Janeiro, Brazil
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surgeon, transsphenoidal surgery results in a remission rate of approximately 85% for microadenomas and 40–60% for macroadenomas ( 8 , 9 ). Several factors are predictors of surgical success: tumor size and invasiveness, preoperative GH level, patient
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the nine cases were diagnosed as CS and underwent transsphenoidal adenomectomy (histopathologically proven), while the remaining seven did not have endogenous hypercortisolism (ODST cortisol <1.8 μg/dl). If these clinically suspicious cases are added
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Department of Clinical Biochemistry, North West London Pathology, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
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summarised in Table 2 . Table 2 Causes of secondary adrenal insufficiency. Cause of secondary adrenal insufficiency Patient population ( n = 48) Pathology requiring trans-sphenoidal pituitary surgery Cushing’s disease
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. ( https://doi.org/10.1210/jc.2011-0197 ) 10.1210/jc.2011-0197 41 Cruz-Topete D Christensen B Sackmann-Sala L Okada S Jorgensen JOL Kopchick JJ. Serum proteome changes in acromegalic patients following transsphenoidal surgery: novel biomarkers of