Vita Birzniece
Vita Birzniece
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Teresa Lam
Teresa Lam
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Mark McLean
Mark McLean
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Navneeta Reddy
Navneeta Reddy
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Haleh Shahidipour
Haleh Shahidipour
School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Amy Hayden
Amy Hayden
School of Medicine, Western Sydney University, New South Wales, Australia
Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Howard Gurney
Howard Gurney
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Glenn Stone
Glenn Stone
School of Computing, Engineering and Mathematics, Western Sydney University, New South Wales, Australia
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Rikke Hjortebjerg
Rikke Hjortebjerg
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Jan Frystyk
Jan Frystyk
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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hypogonadism, it is associated with the development of obesity, insulin resistance, hyperinsulinemia, and increased cardiovascular disease risk ( 1 , 2 ). The metabolic syndrome is present in >50% of men receiving long-term ADT compared to 20% of matched
Chiara Mele
Chiara Mele
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Maria Teresa Samà
Maria Teresa Samà
Division of Endocrinology, University Hospital ‘Maggiore della Carità’, Novara, Italy
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Alessandro Angelo Bisoffi
Alessandro Angelo Bisoffi
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
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Marina Caputo
Marina Caputo
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
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Valentina Bullara
Valentina Bullara
Division of Endocrinology, University Hospital ‘Maggiore della Carità’, Novara, Italy
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Stefania Mai
Stefania Mai
Laboratory of Metabolic Research, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Gillian Elisabeth Walker
Gillian Elisabeth Walker
Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
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Flavia Prodam
Flavia Prodam
Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
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Paolo Marzullo
Paolo Marzullo
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Division of General Medicine, Istituto Auxologico Italiano, IRCCS, S. Giuseppe Hospital, Piancavallo di Oggebbio (VB), Italy
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Gianluca Aimaretti
Gianluca Aimaretti
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
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Loredana Pagano
Loredana Pagano
Division of Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy
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Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy
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-sectional studies and confirmed in meta-analyses of cross-sectional and prospective studies. Many advocate that environmental and lifestyle factors, such as obesity and insulin resistance (IR), could be implicated in the pathogenesis of thyroid cancer ( 2 , 9 , 10
Ling Hu
Ling Hu
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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Ting Li
Ting Li
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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Xiao-Ling Yin
Xiao-Ling Yin
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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Yi Zou
Yi Zou
Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
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the increase in the incidence of TN is related to some components of MS ( 7 ). Researchers in the field have found that MS and insulin resistance are important factors associated with the increased incidence of nodular goiter and thyroid cancer ( 8
Stephen J Winters
Stephen J Winters
Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA
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Charles R Scoggins
Charles R Scoggins
Division of Surgical Oncology, University of Louisville, Louisville, Kentucky, USA
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Duke Appiah
Duke Appiah
Department of Public Health, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
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Dushan T Ghooray
Dushan T Ghooray
Division of Endocrinology, Metabolism and Diabetes, University of Louisville, Louisville, Kentucky, USA
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foregoing patients in order to better understand the relationship between insulin, insulin resistance by HOMA, and hepatic long chain fatty acids and the expression of HNF4α and SHBG in human liver. We hypothesized that both insulin resistance and total
Hong-Fa Yan
Hong-Fa Yan
College of Life and Health Sciences, Northeastern University, Shenyang, China
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Zhao-Yu Liu
Zhao-Yu Liu
College of Life and Health Sciences, Northeastern University, Shenyang, China
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Zhi-Ang Guan
Zhi-Ang Guan
College of Life and Health Sciences, Northeastern University, Shenyang, China
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Chuang Guo
Chuang Guo
College of Life and Health Sciences, Northeastern University, Shenyang, China
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Introduction Type 2 diabetes mellitus (T2DM) is becoming one of the most pressing health issues facing society. Although T2DM is well described in terms of its hallmarks, namely insulin resistance and chronic hyperglycemia, the factors
Nikolaos Kyriakakis
Nikolaos Kyriakakis
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Marilena Giannoudi
Marilena Giannoudi
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Satish S Kumar
Satish S Kumar
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Khyatisha Seejore
Khyatisha Seejore
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Georgios K Dimitriadis
Georgios K Dimitriadis
Department of Endocrinology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
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Harpal Randeva
Harpal Randeva
Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
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Adam Glaser
Adam Glaser
Pediatric Oncology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute of Medical Research, University of Leeds, UK
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Leeds Institute of Medical Research, University of Leeds, UK
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Michelle Kwok-Williams
Michelle Kwok-Williams
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Georgina Gerrard
Georgina Gerrard
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Carmel Loughrey
Carmel Loughrey
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Ahmed Al-Qaissi
Ahmed Al-Qaissi
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Ramzi Ajjan
Ramzi Ajjan
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Julie Lynch
Julie Lynch
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Robert D Murray
Robert D Murray
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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model assessment for insulin resistance (HOMA) equation (fasting plasma glucose (mmol/L) × fasting serum insulin (mU/L) divided by 22.5). The prevalence of metabolic syndrome was determined according to the International Diabetes Federation criteria ( 10
Yao Su
Yao Su
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Li Chen
Li Chen
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Dong-Yao Zhang
Dong-Yao Zhang
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xu-Pei Gan
Xu-Pei Gan
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Yan-Nan Cao
Yan-Nan Cao
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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De-Cui Cheng
De-Cui Cheng
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Wen-Yu Liu
Wen-Yu Liu
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Fei-Fei Li
Fei-Fei Li
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xian-Ming Xu
Xian-Ming Xu
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Hong-Kun Wang
Hong-Kun Wang
Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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short-term health of the mother and the child. However, the etiology of GDM remains unclear. It may be caused by insulin resistance and pancreatic β-cell secretion defects caused by genetic and environmental factors, but recent studies have revealed that
Nikolaj Rittig
Nikolaj Rittig
Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark
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Mads Svart
Mads Svart
Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark
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Niels Jessen
Niels Jessen
Research Laboratory for Biochemical Pathology, Institute for Clinical Medicine, Aarhus University Hospital, Aarhus C, Denmark
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Niels Møller
Niels Møller
Department of Internal Medicine and Endocrinology (MEA) and Medical Research Laboratory, Aarhus University Hospital, Aarhus C, Denmark
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Holger J Møller
Holger J Møller
Department of Clinical Biochemistry Aarhus University Hospital, Aarhus C, Denmark
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Henning Grønbæk
Henning Grønbæk
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus C, Denmark
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as obesity, sepsis, insulin resistance, diabetes mellitus type 2 (DM2) and non-alcoholic fatty liver disease (NAFLD) ( 1 , 2 , 3 , 4 , 5 , 6 ). These diseases are also associated with changes in the lipid metabolism, accelerated lipolysis and
Angela Köninger
Angela Köninger
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Philippos Edimiris
Philippos Edimiris
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Laura Koch
Laura Koch
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Antje Enekwe
Antje Enekwe
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Claudia Lamina
Claudia Lamina
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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Sabine Kasimir-Bauer
Sabine Kasimir-Bauer
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Rainer Kimmig
Rainer Kimmig
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Hans Dieplinger
Hans Dieplinger
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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Department of Gynecology and Obstetrics, Division of Genetic Epidemiology, Vitateq Biotechnology GmbH, University of Duisburg-Essen, D-45122 Essen, Germany
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parameters of oxidative stress such as ‘advanced glycosylation end products’ correlated strongly with anovulation, follicle number, and concentrations of anti-Müllerian hormone (AMH) in patients with PCOS (3) . Although insulin resistance (IR) plays an
Yuka Goto
Yuka Goto
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Yoshie Otsuka
Yoshie Otsuka
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Kenji Ashida
Kenji Ashida
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Ayako Nagayama
Ayako Nagayama
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Nao Hasuzawa
Nao Hasuzawa
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Shimpei Iwata
Shimpei Iwata
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Kento Hara
Kento Hara
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Munehisa Tsuruta
Munehisa Tsuruta
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Nobuhiko Wada
Nobuhiko Wada
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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Seiichi Motomura
Seiichi Motomura
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
Division of Endocrinology and Metabolism, Diabetes Center, Kurume Medical Center, Kokubu-machi, Kurume-city, Fukuoka, Japan
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Division of Endocrinology and Metabolism, Diabetes Center, Kurume Medical Center, Kokubu-machi, Kurume-city, Fukuoka, Japan
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Yuji Tajiri
Yuji Tajiri
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
Division of Endocrinology and Metabolism, Diabetes Center, Kurume Medical Center, Kokubu-machi, Kurume-city, Fukuoka, Japan
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Division of Endocrinology and Metabolism, Diabetes Center, Kurume Medical Center, Kokubu-machi, Kurume-city, Fukuoka, Japan
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Masatoshi Nomura
Masatoshi Nomura
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Asahi-machi, Kurume-city, Fukuoka, Japan
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inhibition of hypoglycemia are required to prevent macrovascular complications ( 1 , 10 , 11 ). In an animal model, SGLT2 inhibitors exerted amelioration effects against insulin resistance by reducing ectopic fat volume ( 12 , 13 ) and increasing the
