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B. Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice . Diabetes 2014 63 880 – 891 . ( https://doi.org/10.2337/db13-0194 ) 24270984 10.2337/db13-0194 50 Ronner P Scarpa A
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increased in adipose tissue of ob/ob mice. Interestingly, the over-expressed PGC-1α in white adipocytes may lead to a phenotype similar to that of brown adipose tissue ( 33 ). Of course, we will need further study to clarify them. Together with the findings
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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IGF bioactivity during metformin treatment may therefore result in a stimulation of lipid use in brown adipose tissue as well, thereby inducing increased lipid utilisation and reduction in fat mass. In line with this, we were able to demonstrate a
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regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice . Regulatory Peptides 2005 130 97 – 103 . ( https://doi.org/10.1016/j.regpep.2005.04.004 ) 52 Cummings DE Purnell JQ Frayo RS Schmidova K Wisse
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA
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) Dichlorodiphenyltrichloroethane (DDT) Pesticide Currently unknown Impairs thermogenesis in brown adipose tissue (BAT), promotes diet induced insulin resistance, promotes transgenerational inheritance of obesity (98, 100, 143) di-2-ethylhexyl (DEHP) Phthalates
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Talukdar S Heine M Fischer AW Krott LM Nilsson SK Brenner MB Heeren J Scheja L . FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues . Cell Metabolism 2016 23 441 – 453 . ( https