Soraya Puglisi
Soraya Puglisi
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Paola Perotti
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Mattia Barbot
Mattia Barbot
Endocrinology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy
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Paolo Cosio
Paolo Cosio
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Carla Scaroni
Carla Scaroni
Endocrinology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy
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Antonio Stigliano
Antonio Stigliano
Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital University of Rome, Rome, Italy
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Pina Lardo
Endocrinology Unit, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital University of Rome, Rome, Italy
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Valentina Morelli
Valentina Morelli
Endocrinology Unit, Department of Clinical Sciences and Community Health, University of Milan and Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
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Elisa Polledri
Elisa Polledri
Department of Clinical Sciences and Community Health, Laboratory of Toxicology, University of Milan and Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy
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Iacopo Chiodini
Iacopo Chiodini
Endocrinology Unit, Department of Clinical Sciences and Community Health, University of Milan and Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy
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Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Anna Pia
Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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to thank Silvia Fustinoni for assistance with lab assays. References 1 Feelders RA Pulgar SJ Kempel A Pereira AM . The burden of Cushing’s disease: clinical and health-related quality of life aspects . European Journal of Endocrinology
Ferdinand Roelfsema
Ferdinand Roelfsema
Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Diana van Heemst
Diana van Heemst
Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
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Ali Iranmanesh
Ali Iranmanesh
Endocrine Section, Medical Service, Salem Veterans Affairs Medical Center, Salem, Virginia, USA
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Paul Takahashi
Paul Takahashi
Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
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Rebecca Yang
Rebecca Yang
Endocrine Research Unit, Mayo Medical and Graduate Schools, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota, USA
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Johannes D Veldhuis
Johannes D Veldhuis
Endocrine Research Unit, Mayo Medical and Graduate Schools, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota, USA
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night. For diagnostic considerations, these subtle physiological adaptations are not relevant in diagnosing major endocrine disruptions such as Cushing’s disease, Cushing’s syndrome and primary and secondary adrenal failure. For these disorders
Susan M Webb
Susan M Webb
IIB-Sant Pau, Research Center for Pituitary Diseases, Barcelona, Spain
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Spain
Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Spain
Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
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Jette Kristensen
Jette Kristensen
ePAG & Chair of Danish Addison Patient Association, Aarhus, Denmark
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Anna Nordenström
Anna Nordenström
Pediatric Endocrinology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
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Diana Vitali
Diana Vitali
ePAG & Chair SOD ITALIA - Italian Patients Organization for Septo Optic Dysplasia and other Neuroendocrine Conditions, Rome, Italy
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Vincent Amodru
Vincent Amodru
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics, Institut MarMaRa, Marseille, France
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Lenja Katharina Wiehe
Lenja Katharina Wiehe
EURORDIS - Rare Diseases Europe, Paris, France
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Matt Bolz-Johnson
Matt Bolz-Johnson
EURORDIS - Rare Diseases Europe, Paris, France
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Anne Jouinot
Anne Jouinot
Department of Medical Oncology, Cochin Hospital, Paris Descartes University, CARPEM, AP-HP, Paris, France
Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
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Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
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Bernard Royer
Bernard Royer
CHU Besançon, Clinical Pharmacology and Toxicology Dpt, Besançon cedex, France
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Etienne Chatelut
Etienne Chatelut
Institut Claudius-Regaud, Université de Toulouse, INSERM, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France
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Sotheara Moeung
Sotheara Moeung
Institut Claudius-Regaud, Université de Toulouse, INSERM, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France
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Guillaume Assié
Guillaume Assié
Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
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Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
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Audrey Thomas-Schoemann
Audrey Thomas-Schoemann
Department of Pharmacy, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France
Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France
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Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France
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Jérôme Bertherat
Jérôme Bertherat
Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Department of Endocrinology, Center for Rare Adrenal Diseases, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
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François Goldwasser
François Goldwasser
Department of Medical Oncology, Cochin Hospital, Paris Descartes University, CARPEM, AP-HP, Paris, France
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Benoit Blanchet
Benoit Blanchet
Pharmacokinetics and Pharmacochemistry Unit, Cochin Hospital, Paris Descartes University, AP-HP, Paris, France
UMR8638 CNRS, Pharmacy UFR, University of Paris Descartes, PRES sorbonne Paris Cité, Paris, France
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J Brossaud
J Brossaud
Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France
Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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V Pallet
V Pallet
Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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J-B Corcuff
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Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France
Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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Department of Nuclear Medicine, CHU de Bordeaux, Pessac, France
INRA, Nutrition et Neurobiologie Intégrée, UMR1286, Bordeaux, France
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to treat Cushing’s disease ( 65 ). Ectopic ACTH secretion may also be affected by retinoids. Indeed, the nuclear co-repressor SMRT is over-expressed in ACTH-secreting thymic carcinoids suggesting that aberrant expression might be involved in the
Athanasios Zervas
Athanasios Zervas
Endocrine Unit, Athens Medical Centre, Athens, Greece
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George Chrousos
George Chrousos
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, Athens, Greece
National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece
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National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece
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Sarantis Livadas
Sarantis Livadas
Endocrine Unit, Athens Medical Centre, Athens, Greece
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cause Cushing’s disease . Nature Genetics 2015 47 31 ‐ 38 . ( https://doi.org/10.1038/ng.3166 ) 34 Guaraldi F Storr HL Ghizzoni L Ghigo E Savage MO Paediatric pituitary adenomas: a decade of change . Hormone Research in Paediatrics
Mônica R Gadelha
Mônica R Gadelha
Endocrine Unit, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Feng Gu
Feng Gu
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Beijing, China
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Marcello D Bronstein
Marcello D Bronstein
Neuroendocrine Unit, Division of Endocrinology and Metabolism, University of São Paulo Medical School, São Paulo, Brazil
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Thierry C Brue
Thierry C Brue
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Marseille Medical Genetics, and Assistance Publique Hôpitaux de Marseille, Department of Endocrinology, Hôpital de la Conception, Centre de Référence des Maladies Rares de l’Hypophyse, Marseille, France
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Maria Fleseriu
Maria Fleseriu
Northwest Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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Ilan Shimon
Ilan Shimon
Institute of Endocrinology and Metabolism, Rabin Medical Center, and Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva, Israel
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Aart J van der Lely
Erasmus University Medical Center, Rotterdam, The Netherlands
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Shoba Ravichandran
Shoba Ravichandran
Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA
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Albert Kandra
Recordati AG, Basel, Switzerland
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Alberto M Pedroncelli
Recordati AG, Basel, Switzerland
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Annamaria A L Colao
Annamaria A L Colao
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy
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acromegaly can be obtained. However, experience with managing pasireotide-related hyperglycemia in patients with Cushing’s disease has led to the following recommendations on managing elevated blood glucose levels in these patients. Hyperglycemia should be
G Giuffrida
G Giuffrida
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
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PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
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F Ferraù
F Ferraù
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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R Laudicella
Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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O R Cotta
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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E Messina
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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F Granata
F Granata
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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F F Angileri
F F Angileri
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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A Vento
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Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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A Alibrandi
Department of Economics, University of Messina, Messina, Sicily, Italy
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Nuclear Medicine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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S Cannavò
Endocrine Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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Marcus Quinkler
Marcus Quinkler
Endocrinology in Charlottenburg, Berlin, Germany
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Bertil Ekman
Bertil Ekman
Departments of Endocrinology and Medical and Health Sciences, Linköping University, Linköping, Sweden
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Claudio Marelli
Claudio Marelli
Shire International GmbH, Zug, Switzerland
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Sharif Uddin
Shire, Lexington, Massachusetts, USA
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Pierre Zelissen
Pierre Zelissen
Department of Internal Medicine and Endocrinology, University Medical Center Utrecht, Utrecht, the Netherlands
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Robert D Murray
Robert D Murray
Department of Endocrinology, Leeds Teaching Hospitals NHS Trust, St James’s University Hospital, Leeds, UK
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on behalf of the EU-AIR Investigators
on behalf of the EU-AIR Investigators
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Department of Endocrinology, Waikato Hospital, Hamilton, New Zealand
Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand
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Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand
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Department of Endocrinology, Waikato Hospital, Hamilton, New Zealand
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M Swarbrick
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Department of Radiology, Waikato Hospital, Hamilton, New Zealand
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M S Dray
M S Dray
Department of Pathology, Waikato Hospital, Hamilton, New Zealand
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Department of Oncology, Tauranga Hospital, Tauranga, New Zealand
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J V Conaglen
J V Conaglen
Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand
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CRH production rather than Cushing’s disease (CD). Computed tomography (CT) of the chest, abdomen and pelvis was initially reported as normal. As no causative lesion was identified on imaging, the patient was transferred to a university hospital for
