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C Sui Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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Q He Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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R Du Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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D Zhang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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F Li Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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G Dionigi Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood ‘G. Barresi’, University Hospital ‘G. Martino’, The University of Messina, Messina, Italy

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N Liang Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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H Sun Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Precision Medicine Laboratory of Molecular Biology and Translational Medicine on Differentiated Thyroid Carcinoma, Changchun City, China

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China. Surgical treatment was performed by dedicated surgeons who belonged to the same high-volume TC surgical unit and who have extensive experience in endocrine surgery (i.e. 3500 thyroidectomies/year and 100,000 outpatients/year). Study

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Lu Yang Department of Nuclear Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Xingguo Jing Department of Nuclear Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Hua Pang Department of Nuclear Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Lili Guan Department of Nuclear Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Mengdan Li Department of Nuclear Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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of histological cellular hyperplasia in more than one gland after surgical and pathological evaluation of any enlarged gland ( 17 ). Sporadic MGD, on the other hand, is described on the basis of the exclusion of congenital and familial PHPT. Regarding

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Jing Zhang Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Zhiyong Zhao Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Li Dong Department of Pathology, Lanzhou University Second Hospital, Lanzhou, China

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Tao Han Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Guojin Zhang Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Yuntai Cao Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Junlin Zhou Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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, 7 ). However, precise preoperative distinction between these two tumors may aid the determination of a suitable surgical planning. Most sellar meningiomas may require a craniotomy and Dzhindzhikhadze et al ., have reported that a transpalpebral

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David T Broome Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Gauri B Gadre Department of Internal Medicine, Scripps Clinic, La Jolla, California, USA

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Ehsan Fayazzadeh Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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James F Bena Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Christian Nasr Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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.022 c  Tumor size 3.6 (0.20, 14.0) 4.0 (0.20, 12.0) 3.0 (1.00, 14.0) 0.74 b 3.0 (1.5, 14.0) 7.0 (1.00, 9.0) 0.60 b Completeness of surgery 0.53 c 0.21 c  Completely resected 112 (78.3) 72 (80.0) 40 (75

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Klaudia Zajkowska Endocrinology, Holycross Cancer Centre, Kielce, Poland

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Janusz Kopczyński Surgical Pathology, Holycross Cancer Centre, Kielce, Poland

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Stanisław Góźdź Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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Aldona Kowalska Endocrinology, Holycross Cancer Centre, Kielce, Poland
Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland

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between different institutions in the same country (USA, 4.0–27.0%; Korea, 1.3–2.7%), which, at least in part, may be attributable to different study designs (retrospective/prospective), sources of data collection (via cytologic/surgical pathology database

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Tao Mei Department of Neurosurgery, Fuzhou General Hospital, Fuzhou, China
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Jianhe Zhang Department of Neurosurgery, Fuzhou General Hospital, Fuzhou, China

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Liangfeng Wei Department of Neurosurgery, Fuzhou General Hospital, Fuzhou, China

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Xingfeng Qi Department of Pathology, Fuzhou General Hospital, Fuzhou, China

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Yiming Ma Department of Neurosurgery, Liuzhou General Hospital, Liuzhou, China

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Xianhua Liu Department of Pathology, Fuzhou General Hospital, Fuzhou, China

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Shaohua Chen Department of Pathology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China

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Songyuan Li Department of Neurosurgery, Fuzhou General Hospital, Fuzhou, China

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Jianwu Wu Department of Neurosurgery, Fuzhou General Hospital, Fuzhou, China

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Shousen Wang Department of Neurosurgery, Fuzhou General Hospital, Fuzhou, China

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surgically resected PA tumor samples that were pathologically confirmed were collected from January 2013 to April 2017 at the Department of Neurosurgery of Fuzhou General Hospital. Complete medical records, images and pathological specimens were obtained (in

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Keiko Ohkuwa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Ryohei Katoh Department of Pathology, Ito Hospital, Tokyo, Japan

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Mitsuji Nagahama Department of Surgery, Ito Hospital, Tokyo, Japan

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Wataru Kitagawa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kenichi Matsuzu Department of Surgery, Ito Hospital, Tokyo, Japan

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Akifumi Suzuki Department of Surgery, Ito Hospital, Tokyo, Japan

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Chisato Tomoda Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiyomi Hames Department of Surgery, Ito Hospital, Tokyo, Japan

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Junko Akaishi Department of Surgery, Ito Hospital, Tokyo, Japan

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Chie Masaki Department of Surgery, Ito Hospital, Tokyo, Japan

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Kana Yoshioka Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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Introduction Parathyroid carcinoma (PC) is a rare endocrine tumor that accounts for <0.5–5% of patients with primary hyperparathyroidism ( 1 , 2 , 3 , 4 ). Complete surgical resection is the only curative treatment for PC. To prevent local

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Magaly Zappa Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France

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Olivia Hentic Department of Gastroenterology and Pancreatology, AP-HP, Clichy, France

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Marie-Pierre Vullierme Department of Radiology, AP-HP, Clichy, France

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Matthieu Lagadec Department of Radiology, AP-HP, Clichy, France

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Maxime Ronot Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France

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Philippe Ruszniewski Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Gastroenterology and Pancreatology, AP-HP, Clichy, France

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Valérie Vilgrain Univ Paris Diderot, Sorbonne Paris Cité, Paris, France
INSERM, UMR1149 CRI, Paris, France
Department of Radiology, AP-HP, Clichy, France

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can be resected, debulking resection can also be considered to reduce symptoms ( 2 ). When surgical resection cannot be considered, locoregional liver-directed therapies and/or medical therapies may be discussed. In these cases, the therapeutic

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Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK

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Omar Faiz Department of Surgery, St Mark’s Hospital, London, UK

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Robert Goldin Centre for Pathology, Imperial College London, London, UK

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John Martin Department of Gastroenterology, Imperial College London, London, UK

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Harpreet Wasan Department of Surgery and Cancer, Imperial College London, London, UK

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Marc-Olaf Liedke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Erik Schloericke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Anna Malczewska Department of Surgery and Cancer, Imperial College London, London, UK
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Guido Rindi Institute of Anatomic Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Irvin M Modlin Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA

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Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

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pathological analysis of surgical specimens or in the case of those who did not receive surgical treatment for their primary tumour, radiology. For patients with multifocal primary tumours, the largest tumour was used. Only patients with all data required for

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Tiina Vesterinen HUSLAB, Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland

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Teijo Kuopio Department of Biological and Environmental Science, University of Jyväskylä and Department of Pathology, Central Finland Health Care District, Jyväskylä, Finland

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Maarit Ahtiainen Department of Education and Research, Central Finland Central Hospital, Jyväskylä, Finland

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Aija Knuuttila Department of Pulmonary Medicine, Heart and Lung Center, and Cancer Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Harri Mustonen Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Kaisa Salmenkivi HUSLAB, Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Johanna Arola HUSLAB, Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

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Caj Haglund Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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behave much more aggressively. As proposed in a recent paper, PCs should be studied independently of LCNEC and SCLC ( 22 ). Thus, we collected a large, retrospective, and clinically well-characterized series of surgically resected PC tumors to investigate

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