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aim of this article is to explore and review current evidence that associates PCOS with cardiometabolic abnormalities and possibly an increased risk of cardiovascular disease. Insulin resistance, metabolic syndrome, obesity and sleep disturbances
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sleep disorders ( 1 ). At present, the precise extent to which specific inflammatory mediators mediate hypercortisolemia is unknown. This is pertinent because the cytokine family of immunoregulators has many members that include interleukins (IL-1 to IL
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healthy male participants of a not yet published sleep interference study were included from Rochester, MN, USA. Informed consent was obtained from each subject after full explanation of the purpose and nature of all procedures used as approved by the Mayo
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA
Veterans Affairs Medical Center, Ann Arbor, Michigan, USA
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ethical answer is to decline. Many of these patients who are duped into hormone doping suffer from fatigue, unrealistic expectations, and false perceptions of reality, thanks to the demands and vices of modern society. Poor sleep, reliance on heavily
Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
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Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
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comorbidities related to the tumor itself (e.g. headache, oculomotor never palsy or hypopituitarism) or to GH and insulin-like growth factor-1 (IGF-1) excess (arthralgia, morphologic changes, or obstructive sleep apnea (OSA), cardiovascular disease, and
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hydrocortisone in the morning vs a higher dose at night in children, showed no difference in overall 24-h control of markers of adrenal androgen excess ( 2 ). Anecdotally, some patients complain of poor sleep when taking glucocorticoids at night and taking
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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= 97). Initial symptoms A broad range of signs and symptoms were initially noticed by patients, with weight gain, hirsutism or acne, fatigue, sleep disturbances, depressive symptoms, muscle weakness, anxiety and hypertension all being reported
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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/93) Sleep disorder 0.148 Mild 25.9% (7/27) 28.6% (32/112) Severe 33.3% (9/27) 17.0% (19/112) Temperature dysregulation 0.059 Mild 37.5% (3/8) 37.8% (17/45) Severe 25.0% (2/8) 2.2% (1
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Department of Pediatrics, Copenhagen University Hospital - Herlev & Gentofte, Copenhagen, Denmark
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Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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), which require repeated venous sampling. The pathology of several other conditions such as major depression, bipolar disease, stress related to night shifts, nocturia, hypertension, and sleep disorders have all been claimed to include disrupted circadian
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, venous thromboembolism, thrombophilia, known preexisting cardiovascular disease or stroke, initial PSA more than 3 ng/L, severe lower urinary tract symptoms with an International Prostate Symptom Score (IPSS) >19, untreated sleep apnea, initial hematocrit