Ashley K Clift
Ashley K Clift
Department of Surgery and Cancer, Imperial College London, London, UK
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Oskar Kornasiewicz
Oskar Kornasiewicz
Department of Surgery and Cancer, Imperial College London, London, UK
Department of Surgery, Warsaw Medical University, Warsaw, Poland
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Department of Surgery, Warsaw Medical University, Warsaw, Poland
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Panagiotis Drymousis
Panagiotis Drymousis
Department of Surgery and Cancer, Imperial College London, London, UK
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Omar Faiz
Omar Faiz
Department of Surgery, St Mark’s Hospital, London, UK
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Harpreet S Wasan
Harpreet S Wasan
Department of Surgery and Cancer, Imperial College London, London, UK
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James M Kinross
James M Kinross
Department of Surgery and Cancer, Imperial College London, London, UK
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Thomas Cecil
Thomas Cecil
Peritoneal Malignancy Unit, Basingstoke and North Hampshire Hospital, Basingstoke, UK
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Andrea Frilling
Andrea Frilling
Department of Surgery and Cancer, Imperial College London, London, UK
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Right hemicolectomy 32 DOD 20 50 Appendectomy 3 A, NED 21 55 Right hemicolectomy 4 A, NED *Recurrence at 18 months, but disease free at last follow-up. A, alive; DOD, died of disease; DR
Yujie Ren
Yujie Ren
Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Xue Han
Xue Han
Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Yujiang Li
Yujiang Li
Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Guofang Chen
Guofang Chen
Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
Key Laboratory of TCM Syndrome and Treatment of Yingbing (Thyroid Disease) of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
Key Laboratory of TCM Syndrome and Treatment of Yingbing (Thyroid Disease) of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Lin Jiang
Lin Jiang
Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
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Chao Liu
Chao Liu
Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
Key Laboratory of TCM Syndrome and Treatment of Yingbing (Thyroid Disease) of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
Key Laboratory of TCM Syndrome and Treatment of Yingbing (Thyroid Disease) of State Administration of Traditional Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Shuhang Xu
Shuhang Xu
Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
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, which was calculated as follows: IAR (%) = Va/preoperative tumor volume × 100%. The primary outcomes included local tumor progression, recurrence-free survival (RFS), and delayed surgery. Local tumor progression was defined as any of the following ( 23
Ayana Suzuki
Ayana Suzuki
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan
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Mitsuyoshi Hirokawa
Mitsuyoshi Hirokawa
Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan
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Izumi Otsuka
Izumi Otsuka
Secretary Section, Kuma Hospital, Kobe, Japan
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Akihiro Miya
Akihiro Miya
Department of Surgery, Kuma Hospital, Kobe, Japan
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Akira Miyauchi
Akira Miyauchi
Department of Surgery, Kuma Hospital, Kobe, Japan
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Takashi Akamizu
Takashi Akamizu
Department of Internal Medicine, Kuma Hospital, Kobe, Japan
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) Postoperative outcomes Follow-up period mean (range) (years) 11.2 (2.7–13.7) 11.5 (2.3–13.8) 12.4 (2.4–13.8) NS NS Progression free survival rate (10 years) 90.9% 79.6% 95.8% NS NS Recurrence 9.1% (3) 19
Samira M Sadowski
Samira M Sadowski
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Emanuel Christ
Emanuel Christ
Department of Endocrinology, Diabetes and Metabolism, University Hospital of Basel, Basel, Switzerland
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Benoit Bédat
Benoit Bédat
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Attila Kollár
Attila Kollár
Department of Medical Oncology, Inselspital, University of Bern, Bern, Switzerland
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Wolfram Karenovics
Wolfram Karenovics
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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Aurel Perren
Aurel Perren
Institute of Pathology, University of Bern, Bern, Switzerland
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Frédéric Triponez
Frédéric Triponez
Thoracic and Endocrine Surgery, University Hospitals of Geneva, Geneva, Switzerland
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on behalf of the SwissNET registry
on behalf of the SwissNET registry
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following R0 resection, with no evidence of local recurrence or distant metastasis on imaging. Survival analyses using the Kaplan–Meier method were performed to determine outcomes, and log-rank test was performed for comparison. Statistical analyses were
Alberto Giacinto Ambrogio
Alberto Giacinto Ambrogio
Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Massimiliano Andrioli
Massimiliano Andrioli
Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Martina De Martin
Martina De Martin
Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Francesco Cavagnini
Francesco Cavagnini
Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Francesca Pecori Giraldi
Francesca Pecori Giraldi
Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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in others. This has given rise to the search for reliable markers of recurrence ( 1 , 7 ), usually at immediate postsurgical testing, but none has proven fully predictive for long-term, relapse-free survival. One potential recurrence prognostic is
B C M Hermans
B C M Hermans
Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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J L Derks
J L Derks
Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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H J M Groen
H J M Groen
Department of Pulmonary Diseases, University of Groningen and University Medical Centre, Groningen, The Netherlands
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J A Stigt
J A Stigt
Department of Pulmonary Diseases, Isala Hospital, Zwolle, The Netherlands
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R J van Suylen
R J van Suylen
Pathology-DNA, Jeroen Bosch Hospital, ‘s Hertogenbosch, The Netherlands
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L M Hillen
L M Hillen
Department of Pathology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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E C van den Broek
E C van den Broek
PALGA Foundation, Utrecht, The Netherlands
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E J M Speel
E J M Speel
Department of Pathology, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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A-M C Dingemans
A-M C Dingemans
Department of Pulmonary Diseases, GROW School for Oncology & Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands
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; PFS, progression-free survival; PR, partial response; PY, packyears; RTx, radiotherapy; SRT, stereotactic radiotherapy; WBRT, whole brain radiotherapy. Mean Ki-67 PI was 59% (range 15–100%, Table 2 ). In 6/11 LCNEC Ki-67 PI was ≤40%. Both
Ashley K Clift
Ashley K Clift
Department of Surgery and Cancer, Imperial College London, London, UK
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Omar Faiz
Omar Faiz
Department of Surgery, St Mark’s Hospital, London, UK
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Robert Goldin
Robert Goldin
Centre for Pathology, Imperial College London, London, UK
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John Martin
John Martin
Department of Gastroenterology, Imperial College London, London, UK
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Harpreet Wasan
Harpreet Wasan
Department of Surgery and Cancer, Imperial College London, London, UK
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Marc-Olaf Liedke
Marc-Olaf Liedke
Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany
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Erik Schloericke
Erik Schloericke
Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany
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Anna Malczewska
Anna Malczewska
Department of Surgery and Cancer, Imperial College London, London, UK
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland
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Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland
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Guido Rindi
Guido Rindi
Institute of Anatomic Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy
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Mark Kidd
Mark Kidd
Wren Laboratories, Branford, Connecticut, USA
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Irvin M Modlin
Irvin M Modlin
Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA
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Andrea Frilling
Andrea Frilling
Department of Surgery and Cancer, Imperial College London, London, UK
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. Nomograms predicting progression-free survival, overall survival, and pelvic recurrence in locally advanced cervical cancer developed from an analysis of identifiable prognostic factors in patients from nrg oncology/gynecologic oncology group randomized
Logan Mills
Logan Mills
Institute of Liver Studies, King’s College Hospital, London, UK
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Panagiotis Drymousis
Panagiotis Drymousis
Department of Surgery and Cancer, Imperial College, London, UK
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Yogesh Vashist
Yogesh Vashist
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Christoph Burdelski
Christoph Burdelski
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Andreas Prachalias
Andreas Prachalias
Department of Surgery, King’s College Hospital, London, UK
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Parthi Srinivasan
Parthi Srinivasan
Department of Surgery, King’s College Hospital, London, UK
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Krishna Menon
Krishna Menon
Department of Surgery, King’s College Hospital, London, UK
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Corina Cotoi
Corina Cotoi
Department of Histopathology, King’s College Hospital, London, UK
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Saboor Khan
Saboor Khan
Department of Surgery, University Hospitals Coventry and Warwickshire, Coventry, UK
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Judith Cave
Judith Cave
Department of Oncology, University Hospital, Southampton, UK
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Thomas Armstrong
Thomas Armstrong
Department of Surgery, University Hospital, Southampton, UK
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Martin O Weickert
Martin O Weickert
Department of Endocrinology, University Hospitals Coventry and Warwickshire, Coventry, UK
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Jakob Izbicki
Jakob Izbicki
Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany
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Joerg Schrader
Joerg Schrader
Departments of Gastroenterology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Andreja Frilling
Andreja Frilling
Department of Surgery and Cancer, Imperial College, London, UK
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John K Ramage
John K Ramage
Institute of Liver Studies, King’s College Hospital, London, UK
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Raj Srirajaskanthan
Raj Srirajaskanthan
Institute of Liver Studies, King’s College Hospital, London, UK
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.005; *** P < 0.001. HR, hazard ratio; LNR, lymph node ratio; PFS, progression-free survival. Progression was defined by local recurrence, new or progressive metastases or death ( Table 4 ). The 11 cases of local recurrence were associated
Guoquan Zhu
Guoquan Zhu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Yuying Deng
Yuying Deng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China
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well as those with various subtypes of PTC. In addition, the BRAF V600E mutation was associated with poorer recurrence-free probability in Kaplan–Meier survival analyses in various clinicopathologic categories. Thus, the author suggested that the
Wentao Zhou
Wentao Zhou
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Tiantao Kuang
Tiantao Kuang
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Xu Han
Xu Han
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Wenqi Chen
Wenqi Chen
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Xuefeng Xu
Xuefeng Xu
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Wenhui Lou
Wenhui Lou
Department of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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Dansong Wang
Dansong Wang
The Research Institution of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
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dynamic enhanced CT or MRI. The primary outcome of this research is relapse-free survival (RFS), which was determined by the interval between the day of operation and the date of relapse or last follow-up. Similarly, overall survival (OS) was defined as
