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the definition of the International Task Force of Obesity (13). Measurements At baseline and one year later (end-of-lifestyle intervention), steroid hormones (progesterone, 17-hydroxyprogesterone, 17-hydroxyprogenolon, 11-deoxycorticosterone
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in men were significantly higher than women for estrone, estradiol, testosterone, androstenedione, 17-hydroxypregnenolone, 17-hydroxy-progesterone and sex hormone binding globuline ( Table 3 ). The distribution of the steroid concentrations by sex are
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, s-prolactin, serum cortisol (s-cortisol), serum follicle-stimulating hormone (s-FSH), serum luteinizing hormone (s-LH), serum estrogen (s-estrogen) and serum progesterone (s-progesterone). If the first SBT was O-RV for each hormone ( Table 1 ), the
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( 1 , 2 , 3 ). In the cumulus, the production and accumulation of hyaluronan and associated factors in the extracellular space results in cumulus expansion ( 4 ). Gonadotropins also stimulate the production of progesterone (P4) and prostaglandin E2
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estrogen along with ovulation cycles, the lack of progesterone inhibition on endometrial proliferation and the absence of differentiation into the secretion phase ( 7 ). Of course, PCOS should no longer be considered just as a gynecologic condition, because
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(Italy). HPLC-grade methanol (MeOH) was purchased from Thermo Fischer Scientific. 6 PLUS1 Multilevel Serum Calibrator Set MassChrom Steroids Panel 1&2 allowing the simultaneous quantification of 7 steroids (progesterone, 11-deoxycorticosterone
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all patients with embryos cultured in a time-lapse incubator during the period January 1, 2016 to December 31, 2017 were evaluated. Exclusion criteria were non-fresh transfers due to endometrial polyps, premature progesterone elevation and the use of
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gene was carried out according to the Comparative CT Method for relative quantification of gene expression ( 23 ). Concentrations of estradiol and progesterone were measured using commercially available ELISA kits (NovaTec Immundiagnostica, Germany). A
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lipid peroxides or excess of progesterone synthesis, both of which may contribute to the etiopathogenesis of preeclampsia ( 5 ). The World Health Organization does not recommend the universal screening of serum 25OHD levels during pregnancy but in
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, including progesterone, estradiol, and androgens. On the other hand, the role of adipokines in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), gonadotropins, and steroids suggesting their involvement in the implantation process ( 12