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Rosalie Cabry
Rosalie Cabry
Amiens University, Amiens, Haut-de-France, France
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Philippe Merviel
Philippe Merviel
Brest University, Brest, Bretagne, France
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Aicha Madkour
Aicha Madkour
Mohammed V University of Rabat, Reproductive Medicine, Rabat, Morocco
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Elodie Lefranc
Elodie Lefranc
Amiens University, Amiens, Haut-de-France, France
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Florence Scheffler
Florence Scheffler
Amiens University, Amiens, Haut-de-France, France
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Rachel Desailloud
Rachel Desailloud
Amiens University, Amiens, Haut-de-France, France
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Véronique Bach
Véronique Bach
Amiens University, Amiens, Haut-de-France, France
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Moncef Benkhalifa
Moncef Benkhalifa
Amiens University, Amiens, Haut-de-France, France
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X Lan Y Chen P , Pyrethroid pesticide exposure and risk of primary ovarian insufficiency in Chinese women . Environmental Science and Technology 2018 52 3240 – 3248 . ( https://doi.org/10.1021/acs.est.7b06689 ) 33 Pan W Ye X Yin
Ghazala Zaidi
Ghazala Zaidi
Departments of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Vijayalakshmi Bhatia
Vijayalakshmi Bhatia
Departments of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Saroj K Sahoo
Saroj K Sahoo
Departments of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Aditya Narayan Sarangi
Aditya Narayan Sarangi
Departments of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Niharika Bharti
Niharika Bharti
Departments of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Li Zhang
Li Zhang
Department of Immunology, Barbara Davis Centre for Childhood Diabetes, Denver, USA
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Liping Yu
Liping Yu
Department of Immunology, Barbara Davis Centre for Childhood Diabetes, Denver, USA
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Daniel Eriksson
Daniel Eriksson
Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
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Sophie Bensing
Sophie Bensing
Department of Molecular Medicine and Surgery, Karolinska Institutet, and Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
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Olle Kämpe
Olle Kämpe
Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden
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Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden
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Nisha Bharani
Nisha Bharani
Department of Endocrinology, Amrita Institute of Medical Sciences, Kochi, India
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Surendra Kumar Yachha
Surendra Kumar Yachha
Departments of Paediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Anil Bhansali
Anil Bhansali
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Alok Sachan
Alok Sachan
Department of Endocrinology, Sri Venkateshwara Institute of Medical Sciences, Tirupathi, India
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Vandana Jain
Vandana Jain
Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India
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Nalini Shah
Nalini Shah
Department of Endocrinology, King Edward Memorial Hospital, Seth GS Medical College, Mumbai, India
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Rakesh Aggarwal
Rakesh Aggarwal
Departments of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Amita Aggarwal
Amita Aggarwal
Departments of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Muthuswamy Srinivasan
Muthuswamy Srinivasan
Departments of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Sarita Agarwal
Sarita Agarwal
Departments of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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Eesh Bhatia
Eesh Bhatia
Departments of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
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(one patient each) Primary ovarian insufficiency b 3/5 (60) Hypogonadotropic hypogonadism 1 (4.5) T1DM 2 (9) AIH 2 (9) Diarrhoea/obstipation 6 (27) Anaemia 7 (32) 4/7 patients with anaemia
Mikkel Andreassen
Mikkel Andreassen
Department of Endocrinology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Ulla Feldt-Rasmussen
Ulla Feldt-Rasmussen
Department of Endocrinology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Niels Jørgensen
Niels Jørgensen
Department of Growth and Reproduction, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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gonadotropins have been documented in other clinical conditions such as anorexia nervosa ( 34 ), polycystic ovarian disease ( 35 ) and primary male hypogonadism ( 36 ). Thus, as for TSH, immunoreactive FSH and LH may not reflect FSH and LH bioactivity in
Milène Tetsi Nomigni
Milène Tetsi Nomigni
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Sophie Ouzounian
Sophie Ouzounian
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Alice Benoit
Alice Benoit
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Jacqueline Vadrot
Jacqueline Vadrot
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Frédérique Tissier
Frédérique Tissier
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Sylvie Renouf
Sylvie Renouf
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Hervé Lefebvre
Hervé Lefebvre
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Sophie Christin-Maitre
Sophie Christin-Maitre
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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Estelle Louiset
Estelle Louiset
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
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hyperandrogenism, after exclusion of other pathologies such as 21-hydroxylase (OH) deficiency, androgen-secreting tumors or Cushing's syndrome (4) . Androgen-secreting tumors are typically ovarian or adrenal tumors. They represent less than 0.2% of
Panagiotis Anagnostis
Panagiotis Anagnostis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Irene Lambrinoudaki
Irene Lambrinoudaki
2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
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John C Stevenson
John C Stevenson
National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
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Dimitrios G Goulis
Dimitrios G Goulis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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.2016.2415 ) 33 Tao XY Zuo AZ Wang JQ Tao FB . Effect of primary ovarian insufficiency and early natural menopause on mortality: a meta-analysis . Climacteric 2016 19 27 – 36 . ( https://doi.org/10.3109/13697137.2015.1094784 ) 34 Roeters
Jennifer K Y Ko
Jennifer K Y Ko
Department of Women’s Health, University College London Hospital, London, UK
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Thomas F J King
Thomas F J King
Department of Women’s Health, University College London Hospital, London, UK
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Louise Williams
Louise Williams
Department of Women’s Health, University College London Hospital, London, UK
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Sarah M Creighton
Sarah M Creighton
Department of Women’s Health, University College London Hospital, London, UK
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Gerard S Conway
Gerard S Conway
Department of Women’s Health, University College London Hospital, London, UK
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.1080/13697130903007389 ) 6 POI Guideline Development Group . ESHRE guideline. Management of women with premature ovarian insufficiency. December 2015 Grimbergen, Belgium : ESHRE , 2015 . (available at: https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Management-of-premature-ovarian-insufficiency
Felix Reschke
Felix Reschke
Auf Der Bult Children’s Hospital, Centre for Paediatric Endocrinology, Diabetology, and Clinical Research, Hannover, Germany
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Torben Biester
Torben Biester
Auf Der Bult Children’s Hospital, Centre for Paediatric Endocrinology, Diabetology, and Clinical Research, Hannover, Germany
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Thekla von dem Berge
Thekla von dem Berge
Auf Der Bult Children’s Hospital, Centre for Paediatric Endocrinology, Diabetology, and Clinical Research, Hannover, Germany
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Dagmar Jamiolkowski
Dagmar Jamiolkowski
Auf Der Bult Children’s Hospital, Department of Paediatric Dermatology, Hannover, Germany
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Laura Hasse
Laura Hasse
Auf Der Bult Children’s Hospital, Department of Paediatric Dermatology, Hannover, Germany
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Francesca Dassie
Francesca Dassie
Padua University Hospital, Clinica Medica 3, Department of Medicine (DIMED), Padova, Veneto, Italy
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Pietro Maffei
Pietro Maffei
Padua University Hospital, Clinica Medica 3, Department of Medicine (DIMED), Padova, Veneto, Italy
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Katharina Klee
Katharina Klee
Auf Der Bult Children’s Hospital, Centre for Paediatric Endocrinology, Diabetology, and Clinical Research, Hannover, Germany
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Olga Kordonouri
Olga Kordonouri
Auf Der Bult Children’s Hospital, Centre for Paediatric Endocrinology, Diabetology, and Clinical Research, Hannover, Germany
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Hagen Ott
Hagen Ott
Auf Der Bult Children’s Hospital, Department of Paediatric Dermatology, Hannover, Germany
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Thomas Danne
Thomas Danne
Auf Der Bult Children’s Hospital, Centre for Paediatric Endocrinology, Diabetology, and Clinical Research, Hannover, Germany
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immunodeficiency syndrome caused by a mutation in the autoimmune regulatory gene. It is characterised by chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, adrenal insufficiency and primary hypogonadism ( 35 ). CMC is a characteristic feature of APECED
A Bergougnoux
A Bergougnoux
Service de Génétique Moléculaire et de Cytogénétique, Centre Hospitalier Universitaire de Montpellier, Université de Montpellier, Montpellier, France
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L Gaspari
L Gaspari
Département d'Endocrinologie et de Gynécologie Pédiatrique, Hôpital Arnaud de Villeneuve, Université de Montpellier, Montpellier, France
INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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M Soleirol
M Soleirol
Département de Pediatrie, CHU Nîmes, France, Université de Montpellier Faculté de Médecine Montpellier-Nîmes, Montpellier, France
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N Servant
N Servant
Service de Génétique Moléculaire et de Cytogénétique, Centre Hospitalier Universitaire de Montpellier, Université de Montpellier, Montpellier, France
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S Soskin
S Soskin
Département de Pédiatrie, Centre Hospitalier Universitaire Hautepierre de Strasbourg, Strasbourg, France
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S Rossignol
S Rossignol
Département de Pédiatrie, Centre Hospitalier Universitaire Hautepierre de Strasbourg, Strasbourg, France
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K Wagner-Mahler
K Wagner-Mahler
Département de Pédiatrie, CHU Nice, Hôpitaux Pédiatriques de Nice CHU-Lenval, Nice, France
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J Bertherat
J Bertherat
Department of Endocrinology, French Reference Center for Rare Adrenal Disorders, Hôpital Cochin, Université Paris Cité, Institut Cochin, Assitance Publique-Hôpitaux de Paris, Paris, France
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C Sultan
C Sultan
Département d'Endocrinologie et de Gynécologie Pédiatrique, Hôpital Arnaud de Villeneuve, Université de Montpellier, Montpellier, France
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N Kalfa
N Kalfa
Department of Pediatric Urological Surgery, French Reference Center for abnormalities of Genital Development (DevGen), CHU Lapeyronie, Montpellier University, Montpellier, France
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F Paris
F Paris
Service de Génétique Moléculaire et de Cytogénétique, Centre Hospitalier Universitaire de Montpellier, Université de Montpellier, Montpellier, France
Département d'Endocrinologie et de Gynécologie Pédiatrique, Hôpital Arnaud de Villeneuve, Université de Montpellier, Montpellier, France
INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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Département d'Endocrinologie et de Gynécologie Pédiatrique, Hôpital Arnaud de Villeneuve, Université de Montpellier, Montpellier, France
INSERM Unité 1203 (DEFE), Université de Montpellier, Montpellier, France
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M Boudjenah R Guerra-Junior G Maciel-Guerra AT Achermann JC , Mutations in NR5A1 associated with ovarian insufficiency . New England Journal of Medicine 2009 360 1200 – 1210 . ( https://doi.org/10.1056/NEJMoa0806228 ) 14 Tajima T
Luca Persani
Luca Persani
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Biagio Cangiano
Biagio Cangiano
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Marco Bonomi
Marco Bonomi
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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. 1 ). Figure 1 Flowchart for the diagnosis of CeH. CeH, central hypothyroidism; COS, controlled ovarian stimulation; ES, empty sella; IO, iron overload or hemochromatosis; MPHD, multiple pituitary hormone defect; MRI, magnetic resonance imaging
R H M Dykgraaf
R H M Dykgraaf
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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S Schalekamp-Timmermans
S Schalekamp-Timmermans
Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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M C Adank
M C Adank
Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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S A A van den Berg
S A A van den Berg
Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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B M N van de Lang-Born
B M N van de Lang-Born
Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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T I M Korevaar
T I M Korevaar
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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A Kumar
A Kumar
Ansh Labs, Webster, Texas, USA
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B Kalra
B Kalra
Ansh Labs, Webster, Texas, USA
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G V Savjani
G V Savjani
Ansh Labs, Webster, Texas, USA
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E A P Steegers
E A P Steegers
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Y V Louwers
Y V Louwers
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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J S E Laven
J S E Laven
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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be the best marker of ovarian reserve ( 1 , 4 ). It is widely used as a predictor of ovarian response in controlled ovarian stimulation and to predict age‐at‐menopause as well as primary ovarian insufficiency ( 5 , 6 , 7 ). Besides the role of AMH
