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. Therefore, this oncogene represents a key player both in MTC pathogenesis in preclinical models and as molecular target for drugs inhibiting the action of pathogenic oncoproteins. Mouse models are of fundamental importance to evaluate the efficacy of
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). In addition, studies of mutant mouse models for human disorders have also identified roles for genetic modifiers, in affecting the penetrance, dominance, expressivity and pleiotrophy of disease manifestations ( 12 , 13 ). For example, studies of
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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-mediated arthritis and their non-inflammatory controls. Methods Mouse models Mice were housed under standard laboratory conditions on a 12:12-h light–darkness cycle with free access to standard chow and water. Animals were kept at the animal facility of
Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK
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Oxford Liver Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
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employed mouse models ( 18 , 19 ), and evidence in humans has been conflicting and limited by small sample sizes ( 5 , 6 , 7 ). Here, we present the first evidence associating disrupted circadian schedules to NAFLD and NASH in humans. However, it should
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Laboratory Medicine, University of Groningen, University Medical Center, Groningen, the Netherlands
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Department of Internal Medicine, VUMC Free University, Amsterdam, the Netherlands
Wallenberg Laboratory, Sahlgrenska Hospital, University of Gothenburg, Gothenburg, Sweden
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Horaizon BV, Delft, the Netherlands
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. RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model . Journal of Proteome Research 2008 7 4982 – 4991 . ( https://doi.org/10.1021/pr800373m ) 18841877 10.1021/pr800373m 15 Zou H
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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. White adipose tissue (WAT) is specialized for the energy storage in form of triglyceride. In contrast, brown adipose tissue (BAT) possesses a large amount of uncoupling protein 1 ( Ucp1 ) in mitochondria ( 1 ). Experiments in mouse models have
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) 32 Zychowska M Rojewska E Pilat D Mika J . The role of some chemokines from the CXC subfamily in a mouse model of diabetic neuropathy . Journal of Diabetes Research 2015 2015 750182 . ( https://doi.org/10.1155/2015/750182 ) 33 Zychowska
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Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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we used in the present study, a mouse model expressing hIAPP, as well as single human islets cultured in high glucose. We hypothesized that highly functional islets would be more predisposed for amyloid formation. Materials and methods
Adelaide Medical School, The University of Adelaide, Adelaide, Australia
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(Supplement 1) S25 – S37 . ( doi:10.1016/S1096-6374(01)80005-8 ) 38 Alba M Salvatori R. A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency . Endocrinology 2004 145
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EHESP-School of Public Health, Rennes, France
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disruption The three recently published experimental studies on the effect of analgesics on female development are based on rodent (mouse and rat) models. The ovarian development in both rodents and humans is similar and can be divided into four stages of