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Kristin Godang Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway

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Karolina Lundstam Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Charlotte Mollerup Clinic of Breast and Endocrine Surgery, Center HOC, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

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Stine Lyngvi Fougner Department of Endocrinology, St. Olavs Hospital, Trondheim, Norway

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Ylva Pernow Departments of Molecular Medicine, Surgery and Endocrinology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

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Jörgen Nordenström Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

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Thord Rosén Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Svante Jansson Department of Endocrine Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden

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Mikael Hellström Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden

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Jens Bollerslev Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway
Faculty of Medicine, University of Oslo, Oslo, Norway

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Ansgar Heck Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway
Faculty of Medicine, University of Oslo, Oslo, Norway

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the SIPH Study Group
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were analyzed according to the intention-to-treat principle. Potential determinants for the change in LDL-C in the study period were identified by univariate analyses and assessed by linear regression analyses. SPSS versions 23–25 were used for

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Peter Bond Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands

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Tijs Verdegaal Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands

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Diederik L Smit Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands

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associated with an increased risk of thrombosis ( 39 ), and hematocrit is an important determinant of blood viscosity, scaling exponentially in large and linearly in small vessels (capillaries) ( 40 , 41 ). Thrombosis is also a major cause of morbidity and

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Lawrence D Hayes Active Ageing Research Group, Department of Medical and Sport Sciences, University of Cumbria, Lancaster, UK

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Peter Herbert School of Sport, Health and Outdoor Education, Trinity Saint David, University of Wales, Carmarthen, UK

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Nicholas F Sculthorpe Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, UK

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Fergal M Grace Faculty of Health, Federation University, Victoria, Australia

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DT Armamento-Villareal R. Testosterone and adipokines ara are determinants of physical performance, strength, and aerobic fitness in frail, obese, older adults . International Journal of Endocrinology 2014 2014 507395 . ( doi:10

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Po-Chung Cheng Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan

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Chia-Hung Kao Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan

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glycemic control, which can be promptly discussed with the patients during telemedicine sessions ( 20 ). Furthermore, contact with healthcare professionals can improve adherence to a healthy lifestyle and antidiabetic medications ( 21 , 22 ). This study

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Ali Abbasi MRC Epidemiology Unit, Department of Epidemiology and Department of Internal Medicine, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Post Box 285, Cambridge CB2 0QQ, UK
MRC Epidemiology Unit, Department of Epidemiology and Department of Internal Medicine, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Post Box 285, Cambridge CB2 0QQ, UK

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trends and determinants in CArdiovascular disease; MDC, Malmö Diet and Cancer Study; MDC-CC, Malmö Diet and Cancer Cardiovascular Cohort; MPP, Malmö Preventive Project; CVDFACTS, CardioVascular Disease risk FACtors Two-township Study; KORA, Kooperative

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Giuseppe Grande Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Andrea Graziani Department of Medicine, University of Padova, Padova, Italy

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Antonella Di Mambro Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Riccardo Selice Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy

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Alberto Ferlin Unit of Andrology and Reproductive Medicine, University Hospital of Padova, Padova, Italy
Department of Medicine, University of Padova, Padova, Italy

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wasting in male hypogonadism ( 61 ). Therefore, low INSL3 level might be a determinant of low BMD in subjects with KS. Moreover, low levels of INSL3 may explain the limited efficacy of TRT alone on bone status in KS ( 33 ). Estrogens Human and

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Maria Lola Evia-Viscarra Pediatric Endocrinology Department, Research Department, Hospital Regional de Alta Especialidad del Bajío, Boulevard Milenio 130, San Carlos la Roncha, C.P. 37660 León, Guanajuato, Mexico

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Edel Rafael Rodea-Montero Pediatric Endocrinology Department, Research Department, Hospital Regional de Alta Especialidad del Bajío, Boulevard Milenio 130, San Carlos la Roncha, C.P. 37660 León, Guanajuato, Mexico

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Evelia Apolinar-Jiménez Pediatric Endocrinology Department, Research Department, Hospital Regional de Alta Especialidad del Bajío, Boulevard Milenio 130, San Carlos la Roncha, C.P. 37660 León, Guanajuato, Mexico

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Silvia Quintana-Vargas Pediatric Endocrinology Department, Research Department, Hospital Regional de Alta Especialidad del Bajío, Boulevard Milenio 130, San Carlos la Roncha, C.P. 37660 León, Guanajuato, Mexico

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Introduction A sedentary lifestyle and a diet rich in carbohydrates and fats during childhood leads to obesity. In Mexico, the National Health and Nutrition Survey 2012 data estimate a high prevalence of obesity, defined as a BMI ≥ the 95th

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Thera P Links Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Trynke van der Boom Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Wouter T Zandee Division of Endocrinology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Joop D Lefrandt Division of Vascular Medicine, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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earlier found impaired diastolic function. The main finding was a further deterioration of the diastolic function, illustrated in the early diastolic lateral tissue velocity, the e’ lateral and e’ septal, as a hemodynamic determinant of left ventricle

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J Chycki Department of Sports Training, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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A Zajac Department of Sports Training, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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M Michalczyk Department of Sports Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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A Maszczyk Department of Methodology and Statistics, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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J Langfort Department of Sports Nutrition, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland

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of low, moderate and high-intensity in healthy men. These phenotypes can be attributed to different lifestyles and related to non-genetic risk (obesity) or protective (physical activity) factors of non-communicable diseases ( 15 , 16 , 17 , 18

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I M A A van Roessel Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands

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J E Gorter Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands

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B Bakker Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands

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M M van den Heuvel-Eibrink Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands

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M H Lequin Department of Radiology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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J van der Lugt Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands

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L Meijer Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands

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A Y N Schouten-van Meeteren Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands

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H M van Santen Department of Pediatric Neuro-oncology, Princess Máxima Center, Heidelberglaan, CS Utrecht, The Netherlands
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands

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impaired bone health and its associated factors, however, would open doors towards surveillance and prevention, such as combined lifestyle programs and early start of vitamin D, calcium, and/or pituitary hormone substitution. The International Late

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