T L C Wolters
T L C Wolters
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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C D C C van der Heijden
C D C C van der Heijden
Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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N van Leeuwen
N van Leeuwen
Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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B T P Hijmans-Kersten
B T P Hijmans-Kersten
Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
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M G Netea
M G Netea
Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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J W A Smit
J W A Smit
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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D H J Thijssen
D H J Thijssen
Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
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Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
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A R M M Hermus
A R M M Hermus
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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N P Riksen
N P Riksen
Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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R T Netea-Maier
R T Netea-Maier
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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-reactive protein; IL, interleukin; IL18BP, IL18 binding protein; VCAM1, vascular cell adhesion molecule 1; MMP2, matrix metalloproteinase 2; LPS, lipopolysaccharide; PHA, phytohemagglutinin; IL, interleukin; TNFa, tumor necrosis factor alpha; Ra, receptor
Kate E Lines
Kate E Lines
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Mahsa Javid
Mahsa Javid
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Anita A C Reed
Anita A C Reed
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Gerard V Walls
Gerard V Walls
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Mark Stevenson
Mark Stevenson
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Michelle Simon
Michelle Simon
MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK
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Kreepa G Kooblall
Kreepa G Kooblall
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Sian E Piret
Sian E Piret
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Paul T Christie
Paul T Christie
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Paul J Newey
Paul J Newey
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Ann-Marie Mallon
Ann-Marie Mallon
MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK
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Rajesh V Thakker
Rajesh V Thakker
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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+/- mice, which could represent Men1 genetic modifiers. In silico functional analysis revealed variants in genes associated with tumourigenic pathways, including Kras , Wnt2b , Il3ra and Tnfrsf10a , which were associated with Kras, wnt, interleukin
Simon Schimmack
Simon Schimmack
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Yongchao Yang
Yongchao Yang
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Klaus Felix
Klaus Felix
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Markus Herbst
Markus Herbst
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Yixiong Li
Yixiong Li
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
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Miriam Schenk
Miriam Schenk
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Frank Bergmann
Frank Bergmann
Institute of Pathology, Heidelberg University, Heidelberg, Germany
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Thilo Hackert
Thilo Hackert
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Oliver Strobel
Oliver Strobel
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Introduction Pancreatic neuroendocrine neoplasm (pNEN), the most aggressive neuroendocrine malignancy, has an increasing incidence, with 3.2 cases per 1,000,000 inhabitants currently being diagnosed annually in the United States ( 1 , 2 , 3
Fabyan Esberard de Lima Beltrão
Fabyan Esberard de Lima Beltrão
Lauro Wanderley University Hospital, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil
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Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil
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Daniele Carvalhal de Almeida Beltrão
Daniele Carvalhal de Almeida Beltrão
University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil
Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Giulia Carvalhal
Giulia Carvalhal
Center for Biological and Health Sciences, Federal University of Campina Grande, Campina Grande, Paraíba, Brazil
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Fabyo Napoleão de Lima Beltrão
Fabyo Napoleão de Lima Beltrão
Department of Medicine, Faculty of Medical Sciences, João Pessoa, Brazil
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Igor Motta de Aquino
Igor Motta de Aquino
Metropolitan Hospital Dom José Maria Pires, Santa Rita, Paraíba, Brazil
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Thaíse da Silva Brito
Thaíse da Silva Brito
New Hope Medical School – FAMENE, João Pessoa, Paraíba, Brazil
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Barbara Costa Paulino
Barbara Costa Paulino
Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Elisa Aires
Elisa Aires
Postgraduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Bahia, Brazil
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Diana Viegas
Diana Viegas
Internal Medicine Department, rede UniFTC, Salvador, Bahia, Brazil
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Fabio Hecht
Fabio Hecht
The Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
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Bruno Halpern
Bruno Halpern
Weight Control Centre, Hospital 9 de Julho, São Paulo, São Paulo, Brazil
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Liana Clebia De Morais Pordeus
Liana Clebia De Morais Pordeus
Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Maria da Conceição Rodrigues Gonçalves
Maria da Conceição Rodrigues Gonçalves
Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Helton Estrela Ramos
Helton Estrela Ramos
Postgraduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, Bahia, Brazil
Department of Biorregulation, Health Sciences Institute, Federal University of Bahia, Bahia, Brazil
Postgraduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
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Department of Biorregulation, Health Sciences Institute, Federal University of Bahia, Bahia, Brazil
Postgraduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
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. The median age of patients was 62 (50 –74) years and 113 patients (56.5%) were male ( Table 1 ). Figure 1 Flowchart of the study. COVID-19, coronavirus disease-19; IL6, interleukin-6. Table 1 Demographic and clinical
Fernando Aprile-Garcia
Fernando Aprile-Garcia
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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María Antunica-Noguerol
María Antunica-Noguerol
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Maia Ludmila Budziñski
Maia Ludmila Budziñski
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Ana C Liberman
Ana C Liberman
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Eduardo Arzt
Eduardo Arzt
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Instituto de Investigación en Biomedicina de Buenos Aires – CONICET, Departamento de Fisiología, Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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inflammatory response is the local release of a number of inflammatory mediators such as cytokines (interleukin 1 (IL1), IL6, and tumor necrosis factor α (TNFα)), which then act in the CNS activating the hypothalamic–pituitary–adrenal (HPA) axis, the main
Qian Yang
Qian Yang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Wencai Ke
Wencai Ke
Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China
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Fanfan Pan
Fanfan Pan
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Xinmei Huang
Xinmei Huang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Jun Liu
Jun Liu
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Bingbing Zha
Bingbing Zha
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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interleukin (IL)-1α and IL-1β show concentration-dependent negative regulation of NIS ( 16 , 17 ). IL1 is secreted mainly by neutrophils ( 15 ). Previous studies have found that peripheral blood IL-1β decreases in patients with hyperthyroidism. We speculated
Chunliang Yang
Chunliang Yang
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Junyi Li
Junyi Li
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Fei Sun
Fei Sun
The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Haifeng Zhou
Haifeng Zhou
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jia Yang
Jia Yang
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Chao Yang
Chao Yang
Department of Gerontology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, China
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cells. Subsequent studies, however, indicated that SGK1 is widely expressed in various cell types following a vast array of external stimulations, such as transforming growth factor-β (TGF-β) and interleukin 6 (IL-6) ( 4 ). Multiple endocrine hormones
Zeting Li
Zeting Li
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Ling Pei
Ling Pei
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Huangmeng Xiao
Huangmeng Xiao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Nan Chen
Nan Chen
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Fenghua Lai
Fenghua Lai
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Shufang Yue
Shufang Yue
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Changliu Xu
Changliu Xu
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Yanbing Li
Yanbing Li
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Haipeng Xiao
Haipeng Xiao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Xiaopei Cao
Xiaopei Cao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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B Habib AM Baggio LL Meier DT Eppler E Bouzakri K Wueest S Muller YD , et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells . Nature Medicine 2011 17 1481 – 1489
M A Webb
M A Webb
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
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The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
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H Mani
H Mani
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
Diabetes and Endocrinology Department, Kettering General Hospital NHS Foundation Trust, Kettering, UK
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Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
Diabetes and Endocrinology Department, Kettering General Hospital NHS Foundation Trust, Kettering, UK
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S J Robertson
S J Robertson
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
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H L Waller
H L Waller
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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D R Webb
D R Webb
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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C L Edwardson
C L Edwardson
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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D H Bodicoat
D H Bodicoat
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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T Yates
T Yates
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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K Khunti
K Khunti
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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M J Davies
M J Davies
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine condition in women of reproductive age with a reported prevalence of up to 18% ( 1 ). Symptoms of PCOS include excess hair, irregular/absent periods and infertility
Annalisa Blasetti
Annalisa Blasetti
Department of Paediatrics, University of Chieti, Chieti, Italy
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Valeria Castorani
Valeria Castorani
Department of Paediatrics, University of Chieti, Chieti, Italy
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Nella Polidori
Nella Polidori
Department of Paediatrics, University of Chieti, Chieti, Italy
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Ilaria Mascioli
Ilaria Mascioli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Francesco Chiarelli
Francesco Chiarelli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Cosimo Giannini
Cosimo Giannini
Department of Paediatrics, University of Chieti, Chieti, Italy
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secretion in portal circulation, thus impairing linear growth in children ( 20 ). Previously, Van Sickle and colleagues confirmed that adolescents with T1D who reported higher HbA1c values presented higher levels of interleukin-8 (IL-8) and lower IGF-1 serum
