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Gavin P Vinson School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK

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Caroline H Brennan School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK

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evidence for brain HPA function in addiction and shows that it is not autonomous, and its function is closely regulated by and linked to the systemic HPA. Corticotrophin releasing hormone Corticotrophin releasing hormone (CRH) is produced in various parts

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-13-0028
Volume/Issue:
Volume 2: Issue 3
Open access
Peter Bond Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands

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Tijs Verdegaal Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Internal Medicine, Spaarne Gasthuis, Haarlem, the Netherlands

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Diederik L Smit Department of Internal Medicine, Elisabeth TweeSteden Hospital, Tilburg, the Netherlands
Department of Performance and Image-enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands

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will describe how TTh is thought to induce erythropoiesis, discuss the evidence of TTh-induced erythrocytosis as a cause of thrombosis, and conclude on the potential beneficial or detrimental impact of providing therapeutic phlebotomy as a ‘treatment

Article Type:
Review Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-24-0283
Volume/Issue:
Volume 13: Issue 10
Open access
Christian Trummer Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria

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Stefan Pilz Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria

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Verena Schwetz Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria

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Barbara Obermayer-Pietsch Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria

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Elisabeth Lerchbaum Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria

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, evidence is accumulating that vitamin D deficiency is also a risk marker for insulin resistance ( 3 ), cardiovascular disease ( 4 ), infectious and autoimmune diseases ( 1 ), cancer ( 5 ), increased mortality ( 2 ) as well as decreased fertility ( 6

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0009
Volume/Issue:
Volume 7: Issue 3
Open access
Giuseppe Lisco Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

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Anna De Tullio Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

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Olga Disoteo Diabetology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy

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Giuseppina Piazzolla Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

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Edoardo Guastamacchia Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

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Carlo Sabbà Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

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Vincenzo De Geronimo Unit of Endocrinology, Policlinico Morgagni CCD, Catania, Italy

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Enrico Papini Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy

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Vincenzo Triggiani Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy

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nonalcoholic fatty liver disease in randomized clinical trials ( 1 , 2 ) and real-life evidence ( 3 , 4 ). Since the approval, a rising interest has orbited around the GLP-1RAs, resulting in a high prescription rate of this class of medications in patients

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0257
Volume/Issue:
Volume 12: Issue 11
Open access
Qi Che Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Xirong Xiao Department of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China

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Jun Xu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Miao Liu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Yongning Lu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Suying Liu Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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Xi Dong Reproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China

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invasive potential of endometrial cancer cells. We found that E2 could significantly promote endometrial cancer proliferation and invasion, which is consistent with the research results of other groups ( 16 , 17 ). Furthermore, our data provide evidence

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0258
Volume/Issue:
Volume 8: Issue 7
Open access
Kelly Brewer Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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Isabel Nip Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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Justin Bellizzi Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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Jessica Costa-Guda Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Center for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA

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Andrew Arnold Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, Connecticut, USA

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. Some potential causes, such as stabilizing intragenic mutation ( 14 , 15 , 16 ) have not been substantiated by available evidence. Other possibilities, such as epigenetic upregulation via CCND1 promoter hypomethylation ( 17 , 18 ), have not yet

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0055
Volume/Issue:
Volume 10: Issue 3
Open access
Alexis Sudlow Department of Upper GI Surgery, Southmead Hospital, Bristol, UK

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Carel W le Roux Department of Experimental Pathology, University College Dublin, Dublin, Ireland

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Dimitri J Pournaras Department of Upper GI Surgery, Southmead Hospital, Bristol, UK

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surgery than to continue living with the implications of obesity. Moreover, evidence from more than ten randomised controlled trials comparing bariatric surgery to medical care have consistently demonstrated more favourable results with regards to weight

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0467
Volume/Issue:
Volume 9: Issue 2
Open access
Bogumila Urgatz Merck Healthcare KGaA, Darmstadt, Germany

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Kris G Poppe University Hospital CHU Saint Pierre, Free University of Brussels, Brussels, Belgium

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.14 to 1.36) for TSH ≥10.00 μIU/mL) ( 25 ). While these studies added compelling evidence to our understanding of the danger of hypothyroidism per se during pregnancy, it should be noted that they did not differentiate between the effects of overt

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0420
Volume/Issue:
Volume 13: Issue 3
Open access
Renea A Taylor Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Jennifer Lo Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Natasha Ascui Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Matthew J Watt Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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between adulthood obesity and similar (10, 11, 12) or increased risk (8, 13) of developing prostate cancer, the stronger and more compelling epidemiological evidence shows that obese men have a significantly higher risk of being diagnosed with

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-15-0080
Volume/Issue:
Volume 4: Issue 4
Open access
Sophie Howarth Clinical and Translational Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Luca Giovanelli Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Catherine Napier Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Simon H Pearce Clinical and Translational Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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loss, hypoglycaemia and fatigue. Historically, the symptomatic phase was felt to be a point of no return for Addison’s patients, with a lifelong requirement for steroid replacement to avoid fatal adrenal crisis. However, a growing body of evidence

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-22-0305
Volume/Issue:
Volume 12: Issue 1
Open access