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Lingjuan Li Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Jing Qin Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Lin Ren Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Shiyuan Xiang Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Xiaoyun Cao Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China

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Xianglan Zheng Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Zhiwen Yin Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Nidan Qiao Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China

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common surgical complication in these patients is electrolyte disturbance characterized by hypernatremia ( 3 ). Previous studies have estimated the prevalence of hypernatremia in patients with craniopharyngioma to be between 15% and 44.8% ( 4 , 5

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Beril Erdem Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey

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Angela Schulz Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Leipzig, Germany

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Emel Saglar Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey

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Ferhat Deniz Department of Endocrinology, SBÜ Sultan Abdülhamid Han Teaching Hospital, Istanbul, Turkey

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Torsten Schöneberg Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Leipzig, Germany

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Hatice Mergen Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey

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blood electrolyte concentration (hypernatremia), respectively, are capable to sense changes in water balance and serum osmolality. Reduction in blood volume or increase in blood electrolyte concentration induces the release of arginine vasopressin (AVP

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S E Baldeweg Department of Diabetes and Endocrinology, University College London NHS Foundation Trust and Univeristy College London, London, UK

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S Ball Department of Medicine and Endocrinology, Manchester University Foundation Trust & Manchester Academic Health Science Centre Manchester, Manchester, UK

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A Brooke Royal Devon and Exeter NHS Foundation Trust, Exeter, UK

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H K Gleeson Department of Endocrinology, Queen Elizabeth Hospital, Birmingham, UK

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M J Levy University of Leicester and University of Leicester Hospitals Trust, Leicester, UK

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M Prentice Croydon Health Services NHS Trust, Croydon, UK

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J Wass Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology & Metabolism, Oxford, UK

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the Society for Endocrinology Clinical Committee The Society for Endocrinology, Starling House, 1600 Bristol Parkway North, Bristol, UK

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that in patients with hypernatraemia, the type and volume of fluid replacement reflects the standard daily fluid and electrolyte requirement together with a component of the estimated fluid deficit such that correction of hypernatraemia is controlled

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Angelica Sharma Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Katharine Lazarus Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Deborah Papadopoulou Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Hemanth Prabhudev Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Tricia Tan Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Department of Clinical Biochemistry, North West London Pathology, London, UK

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Karim Meeran Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Sirazum Choudhury Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Department of Clinical Biochemistry, North West London Pathology, London, UK

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dataset. The decision to wean prednisolone was made by a panel of endocrinologists in a multi-disciplinary team meeting. Individuals were deemed ‘well’ if they remained asymptomatic, with an adequate blood pressure and normal electrolytes on a replacement

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Kunzhe Lin Department of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, China
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Lingling Lu Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Zhijie Pei Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Shuwen Mu Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Shaokuan Huang Department of Neurosurgery, Guiqian International General Hospital, Guiyang, China

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Shousen Wang Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
Department of Neurosurgery, 900th Hospital, Fuzhou, China

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function, HPA axis function, and electrolyte levels were recorded. The criteria for HPT and HPA hypofunction were based on Bordo et al. ( 2 ). Statistical analysis All statistical analyses were performed using IBM SPSS Statistics for Windows

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Irena Kasacka Department of Histology and Cytophysiology, Medical University of Białystok, Białystok, Poland

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Żaneta Piotrowska Department of Histology and Cytophysiology, Medical University of Białystok, Białystok, Poland

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Natalia Domian Department of Histology and Cytophysiology, Medical University of Białystok, Białystok, Poland

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Alicja Lewandowska Department of Histology and Cytophysiology, Medical University of Białystok, Białystok, Poland

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, 23 , 24 , 25 , 26 , 27 ). Adrenal hormones, which cause the heartbeat to accelerate, have vasoconstrictive properties, as well as regulate water–electrolyte balance and body fluid volume, play a key role in the pathogenesis of hypertension. A

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M P Schuijt Department of Laboratory Medicine, Slingeland Hospital, Doetinchem, The Netherlands
Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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C G J Sweep Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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R van der Steen Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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A J Olthaar Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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N M M L Stikkelbroeck Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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H A Ross Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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A E van Herwaarden Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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against 1 mL HEPES buffer, while rotating the dialysis apparatus at 20 rpm. The HEPES buffer used for equilibrium dialysis was composed to reflect the electrolyte composition and pH of serum and contained in addition to 12.570 g/L N-(2-hydroxyethyl

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Tao Yuan Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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Lanping Jiang Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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Chen Chen Department of Pediatrics, State Key Laboratory of Medical Genetics, Xiangya Hospital, Central South University, Changsha, China

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Xiaoyan Peng Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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Min Nie Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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Xuemei Li Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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Xiaoping Xing Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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Xuewang Li Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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Limeng Chen Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

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indices such as serum and urinary electrolytes, arterial blood gases and electrocardiogram (ECG) results. The reference values used in this study were obtained from data collected by our laboratory regarding the healthy general population on unrestricted

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Dorte Glintborg Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark

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Hanne Mumm Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark

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Jens Juul Holst Department of Biomedical Sciences and NNF Centre for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

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Marianne Andersen Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark

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-reported renal dysfunction, congestive heart disease, depression and eating disorders were excluded. Routine measurements included prolactin, total and free testosterone, TSH, 17-hydroxyprogesterone, liver enzymes, HbA1c, plasma glucose and electrolytes

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Amit Kumar Department of Medicine, Christian Medical College and Hospital, Ludhiana, Punjab, India

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Maria Ghosh Department of Biochemistry, Christian Medical College and Hospital, Ludhiana, Punjab, India

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Jubbin Jagan Jacob Department of Endocrinology, Christian Medical College and Hospital, Ludhiana, Punjab, India

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% and it remains the commonest electrolyte disturbance seen among them ( 2 ). Hyponatremia leads to increases in morbidity, length of hospitalization and mortality among those admitted in hospital ( 3 , 4 , 5 ). A large majority of in-patients with

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